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Keratosis Pilaris + Treatment Pack
Keratosis Pilaris + Treatment Pack
DermExcel™ | Follicure
DermExcel™ | Follicure
Keratosis Pilaris + Treatment Pack
Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack
8% discount
DermExcel™

Keratosis Pilaris + Treatment Pack

Treatment Pack for Keratosis Pilaris Plus

Sale price R 1,871.00 Regular price R 2,034.00
4.9 / 5.0 from 2598 reviews
Sunscreen:

Sunscreen
Skin Smoothing

Skin Smoothing

Moisturizing

Moisturizing

Anti-microbial

Anti-microbial

Unclog Pores

Unclog Pores

↓ inflammation

↓ inflammation

Products included

Free Gifts with your treatment pack

Mini Silicone Scalp Massager

Mini Silicone Scalp Massager

Cotton Bag

Cotton Bag

Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack Keratosis Pilaris + Treatment Pack
Keratosis Pilaris + Treatment Pack
Keratosis Pilaris + Treatment Pack Sale priceR 1,871.00 Regular priceR 2,034.00

MORNING

EVENING
CLEANSE
REPAIR
MOISTURIZE & PROTECT

MORNING

EVENING

Follicure

Chemical Peel Spray

Dermalytic

Dermdefence SPF 50 (optional)

(Based on your selection)

The DermExcel Keratosis Pilaris Treatment Pack encompasses a synergistic trio of products designed to address specific facets of Keratosis Pilaris (KP), a condition known for its rough, scaly skin patches.

Firstly, Follicure embodies the antimicrobial power of 2% Zinc Pyrithione. This ingredient is known for its efficacy against Malassezia yeast, often implicated in exacerbating skin conditions, thus providing a targeted approach towards skin cleansing in KP management.

Secondly, the Dermalytic, a potent keratolytic and intense moisturizer, comprises an emollient and occlusive blend, supplemented with Glycolic acid, Lactic acid, and Urea. Together, these ingredients help dissolve keratin plugs and moisturize the skin. Glycolic and Lactic acid serve as alpha-hydroxy acids, promoting exfoliation of the skin's outermost layer. Urea acts as a humectant, attracting moisture to the skin and aiding in keratin dissolution.

Lastly, the Chemical Peel spray, a unique blend of 10% Glycolic acid and 3% Salicylic acid, further assists in exfoliation while offering anti-inflammatory properties. Salicylic acid, a beta-hydroxy acid, penetrates deeper into the skin, helping to reduce the inflammation and redness often associated with KP.

The DermExcel Keratosis Pilaris Treatment Pack operates as a comprehensive, multi-pronged solution for KP management, focusing on reducing keratin plug formation, alleviating inflammation, and restoring skin's natural softness.

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your frustrations

  • Breakouts, clogged pores, and inflamed skin.
  • Oily and shiny skin with enlarged pores.
  • Premature skin aging.
  • Sensitive skin that reacts to various stimuli and products.

your goals

  • Smooth and healthy skin with no breakouts or inflammation.
  • Comfortable skin sensations with no itching or other skin discomforts.
  • Prevention and correction of premature skin aging, including lines and wrinkles.
  • Regulated sebum (oil) production with clear and minimized pores.
Benefits of your Keratosis Pilaris Plus Skin Type
hydrated skin

hydrated skin

Even Skin Tone

Even Skin Tone

protective barrier

protective barrier

  • Natural Hydration: Your oily skin provides a natural layer of hydration, forming a protective barrier against environmental damage. This helps to keep the skin plump and potentially reduces the appearance of fine lines and wrinkles.

  • Even Skin Tone: The lack of hyperpigmentation issues means that you enjoy a more consistent and even skin tone.

  • Protective Barrier: The excess sebum can act as a protective barrier against environmental aggressors, potentially reducing the impact of pollutants and other irritants.

Barriers to your skin health
Acne Breakouts

Acne Breakouts

excess sebum

excess sebum

Aging skin

Aging skin

Inflammation

Inflammation

  • Breakouts and Acne: The propensity for clogged pores can lead to blackheads, whiteheads, and more severe forms of acne, which can be challenging to manage and may lead to scarring or post-inflammatory hyperpigmentation.

  • Sebum Control: Controlling excess oil and shine, especially in the T-zone area, can be a constant struggle, affecting the skin's overall appearance.

  • Aging Skin: While oily skin may be more resilient to the formation of fine lines and wrinkles, addressing other signs of aging, such as loss of firmness or elasticity, can be complicated by the need to also manage oiliness and enlarged pores.

  • Inflammation: The inflammation associated with breakouts can accelerate skin aging, contribute to wrinkles, and cause skin to lose elasticity over time.

  • Product Selection: Identifying skincare and makeup products that address oiliness, prevent and treat breakouts, and tackle aging signs without irritating can be a complex task.

  • Enlarged pores: The excess oil production can lead to enlarged pores and increase the likelihood of blackheads, whiteheads, and acne, which can be challenging to manage alongside aging skin concerns.

include

  • Anti-inflammatory and anti-microbial agents.
  • Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
  • Pigmentation-disrupting ingredients and chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
  • Sebum regulating and pore minimizing ingredients.
  • Skin identical medical-grade ingredients that penetrate the skin to activate a biological response.

avoid

  • Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
  • Toners and foaming cleansers containing soap & sulfates.
  • Fragrance in skincare products.
  • Harsh anti-bacterial products that disrupt the skin's natural microbiome.
  • Irritating plant extracts and essential oils that will trigger adverse reactions.

Keratosis Pilaris Plus Treatment

Treatment Objectives

Smooth skin texture

Smooth skin texture

Replace dull and dead skin cells with remodeled skin layers. Resurfacing procedures can induce new collagen formation with a more structured pattern.

Regulate sebum

Regulate sebum

Balance oil production to minimize shine and reduce the likelihood of congestion and breakouts without stripping the skin of its natural oils.

Unclog pores

Unclog pores

Dissolve and extract cellular debris and prevent skin cells from clumping together in pores to ensure that the pores remain clear and free from blockages, which can lead to breakouts.

Clear Acne Breakouts

Clear Acne Breakouts

Reduce and eliminate breakouts by down-regulating the inflammatory response and balancing the skin microbiome.

Prevent & Repair Premature Aging

Prevent & Repair Premature Aging

Protect the skin from factors that accelerate aging, such as UV exposure and pollution, and correct existing signs of aging, like fine lines, wrinkles, and loss of elasticity.

DNA Protection and Repair

DNA Protection and Repair

Safeguard and repair UV-induced DNA damage, utilizing a blend of UV defense, Retinol, Niacinamide, and antioxidants. This strategy prevents future damage and aids in the repair of existing cellular impairments.

Keratosis Pilaris Plus Treatment

beneficial active ingredients

Retinoic acid analogue

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects

  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Aloe Vera

Aloe Vera

Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.

Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.

One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.

Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.

Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.

Physiological Effects

  • Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
  • Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
  • Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
  • Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
  • Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
  • Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.

Managing Dermatological Conditions

  • Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
  • Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
  • Eczema and Psoriasis: Its moisturizing, anti-inflammatory, and soothing properties are beneficial in managing symptoms of eczema and psoriasis.
  • Aging Skin: Aloe Vera's antioxidant properties and ability to improve collagen production can help reduce the signs of aging.
  • Skin Hydration: It's a common ingredient in moisturizers and other skin care products for its hydrating properties.

References

  • Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology.
  • Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of aloe vera used for burn wound healing: A systematic review. Burns.
  • Rajeswari, R., Umadevi, M., Rahale, C. S., Pushpa, R., Selvavenkadesh, S., Kumar, K. S., & Bhowmik, D. (2012). Aloe vera: The miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry.
Niacinamide

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Managing Dermatological Conditions

  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid

Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It uniquely penetrates oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.

Salicylic acid works by dissolving skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which helps to reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also can adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together. This helps remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties effectively soften and remove scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Zinc PCA

Zinc PCA

Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.

One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).

In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.

Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.

Physiological Effects

  • Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
  • Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
  • Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
  • Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
  • Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.

Managing Dermatological Conditions

  • Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
  • Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
  • Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
  • Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.

References

  • Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
  • Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
  • Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
  • Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.
Matrixyl 3000

Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.

Physiological Effects

  • Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
  • Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
  • Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
  • Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.

Managing Dermatological Conditions

  • Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
  • Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
  • Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.

Biochemical Mechanism and Clinical Efficacy

Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.

References

  1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
  2. Sederma Inc., "Matrixyl 3000 Technical Overview."
  • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
  • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Acetyl Hexapeptide-8

Acetyl Hexapeptide-8
Acetyl Hexapeptide-8: The Innovative Peptide in Anti-Aging Dermatology

Acetyl Hexapeptide-8 is a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Acetyl Hexapeptide-8 functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.

Physiological Effects

  • Neurotransmitter Inhibition: Acetyl Hexapeptide-8 works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  • Reduction of Expression Lines: Helps to reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
  • Improvement in Skin Texture: Regular use can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.

Special Benefits

Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Acetyl Hexapeptide-8 in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Acetyl Hexapeptide-8 reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).

References

  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Vitamin E

Vitamin E

The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.

Physiological Effects

  • Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
  • Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
  • Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
  • Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
  • Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.

Managing Dermatological Conditions

  • Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
  • Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
  • Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
  • Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
  • Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.

References

  • Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
  • Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
  • Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
  • Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
  • Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Coenzyme Q10

Coenzyme Q10

CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.

Physiological Impact

  • Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
  • Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.

Pharmacological Advantages

  • Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
  • Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.

Biochemical Benefits

  • Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
  • Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Sunscreen

Sunscreen

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.

Managing Dermatological Conditions

  • Prevention of Sunburn: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
  • Skin Cancer Prevention: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
  • Prevention of Photoaging: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
  • Protection Against Photosensitivity: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
  • Hyperpigmentation and Melasma: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
  • General Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.

References

  • Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
  • Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
  • Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.

Keratosis Pilaris Plus Treatment

products in your treatment pack

DermExcel™ | Follicure
DermExcel™ | Follicure
Follicure Follicure Follicure Follicure
DermExcel™

Follicure

Sale priceR 497.00
4.9 / 5.0 from 434 reviews

SIZE: 120 mL

healthy scalp

healthy scalp

anti-dundruff

anti-dundruff

↓ inflammation

↓ inflammation

oil control

oil control

Itch Relief

Itch Relief

A maximum-strength medicated scalp treatment relieves the itching, irritation, redness, flaking, and scaling associated with dandruff and seborrheic dermatitis.

A powerful formula that combines 2% Salicylic acid and 2% Zinc Pyrithione for maximum effectiveness and life-changing results.

Zinc Pyrithione, an antifungal, antimicrobial, and antibacterial agent, works by reducing the amount of fungus that triggers inflammation and scaling. Zinc Pyrithione also treats pityrosporum folliculitis (fungal acne) on the face and other body parts.

Salicylic acid gently exfoliates the scalp, removing dead skin cells and excess oil, contributing to dandruff and itchiness. As a result, it unclogs hair follicles, promoting a healthier scalp environment.

Zinc Pyrithione

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological Effects

  • Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  • Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  • Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  • Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Managing Dermatological Conditions

  • Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  • Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  • Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  • Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.
Salicylic acid

Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, Salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Learn more on Follicure

Follicure Follicure Follicure Follicure
DermExcel™ | Chemical Peel Spray
DermExcel™ | Exfoliators
Chemical Peel Spray Chemical Peel Spray Chemical Peel Spray Chemical Peel Spray
DermExcel™

Chemical Peel Spray

Sale priceR 715.00
4.9 / 5.0 from 470 reviews

SIZE: 50 mL

Exfoliating

Exfoliating

Smooth Skin

Smooth Skin

Ingrown hair

Ingrown hair

Anti-Acne

Anti-Acne

Anti-Aging

Anti-Aging

Chemical Peel Spray, fortified with a blend of 10% Glycolic acid and 3% Salicylic acid, is a potent skincare solution designed to combat the visible signs of aging and address body acne concerns, including back and buttocks acne. Crafted with medical-grade ingredients, this innovative formula offers a multifaceted approach to skin rejuvenation.

Salicylic acid facilitates deep penetration into the pores, effectively targeting and eliminating pimples, blackheads, Keratosis Pilaris, and unsightly ingrown hair bumps. By exfoliating the skin's surface, this powerful ingredient helps unclog congested pores, promoting a clearer complexion.

Chemical Peel Spray has a rapid drying time. Within seconds of application, the liquid thoroughly dries on the skin without leaving any residue. This unique attribute allows for hassle-free use, enabling you to conveniently apply the product and proceed with your daily routine without concerns of fabric staining.

Chemical Peel Spray embodies the convergence of scientific expertise and dermatological innovation. Empower yourself with this exceptional skincare solution, engineered to enhance your skin's appearance and restore its natural radiance.

Glycolic acid

Glycolic acid

Glycolic acid is highly acclaimed for its remarkable exfoliating and rejuvenating properties. Its small molecular size enables deep skin penetration, fostering efficient exfoliation at the cellular level.

Glycolic acid’s water solubility allows it to penetrate the upper layers of the skin easily. Its primary mechanism of action involves weakening the bonds between dead skin cells, promoting their shedding, and revealing the newer, healthier skin beneath. This process of accelerated cell turnover is instrumental in addressing a range of skin concerns, from aging signs like fine lines and wrinkles to texture irregularities and hyperpigmentation.

Glycolic acid's efficacy extends beyond mere exfoliation. It's also recognized for stimulating collagen production, a crucial protein in maintaining skin's elasticity and firmness. This aspect contributes to its anti-aging benefits. Furthermore, its hydrating properties add to its appeal, as they help increase the skin's capacity to retain moisture, leading to a more supple and vibrant complexion.

Clinical studies have consistently supported glycolic acid's role in improving skin appearance. Research indicates significant improvements in skin texture and pigmentation and the visible reduction of wrinkles and fine lines with glycolic acid.

Physiological Effects

  • Exfoliation: Glycolic acid is a powerful exfoliant. It dissolves the bonds between dead skin cells on the skin’s surface, facilitating their removal and revealing newer, healthier skin underneath.
  • Increased Collagen Production: It stimulates collagen production, which is essential for skin elasticity and firmness. This action helps reduce the appearance of fine lines and wrinkles.
  • Enhanced Skin Hydration: Glycolic acid improves the skin's ability to retain moisture, enhancing hydration and a more plump, vibrant skin appearance.
  • Skin Brightening: Removing dead skin cells can brighten the complexion and reduce the appearance of dark spots and hyperpigmentation.
  • Improved Skin Texture: Regular use of glycolic acid can lead to smoother, more even textured skin, making it beneficial for conditions like keratosis pilaris.
  • Acne Treatment: Its exfoliating properties help in unclogging pores, thereby reducing the occurrence of acne breakouts.

Managing Dermatological Conditions

  • Aging Skin: Glycolic acid is widely used in anti-aging products to reduce signs of aging, such as fine lines, wrinkles, and age spots.
  • Acne-Prone Skin: It helps manage acne by exfoliating the skin and removing blockage from pores.
  • Hyperpigmentation: It effectively treats hyperpigmentation by accelerating the removal of hyperpigmented skin cells.
  • Textural Irregularities: Glycolic acid can improve skin texture and is beneficial for treating keratosis pilaris and other conditions of rough skin.
  • Sun-Damaged Skin: It helps rejuvenate sun-damaged skin by accelerating cell turnover and collagen synthesis.

References

  • Bernstein, E. F. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology, 35(3), 388-391.
Salicylic acid

Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Managing Dermatological Conditions

  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with peratosis Pilaris.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Learn more on Chemical Peel Spray

Chemical Peel Spray Chemical Peel Spray Chemical Peel Spray Chemical Peel Spray
DermExcel™ | Dermalytic
DermExcel™ | Dermalytic
DermExcel™ | Dermalytic
Dermalytic Dermalytic Dermalytic Dermalytic
DermExcel™

Dermalytic

Sale priceR 305.00
4.9 / 5.0 from 470 reviews
Ingrown hair

Ingrown hair

Body Acne

Body Acne

Keratosis Pilaris

Keratosis Pilaris

Rough Skin

Rough Skin

cracked heels

cracked heels

A potent and clinically formulated ointment that effectively treats calloused, rough, and dry skin. It's more than a standard moisturizer; it exfoliates dead skin cells and replenishes moisture. The product creates an optimal environment for skin health, leading to a smoother complexion.

Key ingredients include 10% Glycolic acid for exfoliation, 10% Lactic acid for removing dead cells, and 20% Urea for lasting hydration. Its "cream-ointment" base balances efficacy and application comfort. Dermalytic's medical-grade formula and scientific skincare approach visibly improve skin texture, giving users a renewed sense of confidence and comfort.

Note: Dermalytic is too potent for facial use.

Glycolic acid

Glycolic acid

Glycolic acid is highly acclaimed for its remarkable exfoliating and rejuvenating properties. Its small molecular size enables deep skin penetration, fostering efficient exfoliation at the cellular level.

Glycolic acid’s water solubility allows it to penetrate the upper layers of the skin easily. Its primary mechanism of action involves weakening the bonds between dead skin cells, promoting their shedding, and revealing the newer, healthier skin beneath. This process of accelerated cell turnover is instrumental in addressing a range of skin concerns, from aging signs like fine lines and wrinkles to texture irregularities and hyperpigmentation.

Glycolic acid's efficacy extends beyond mere exfoliation. It's also recognized for stimulating collagen production, a crucial protein in maintaining skin's elasticity and firmness. This aspect contributes to its anti-aging benefits. Furthermore, its hydrating properties add to its appeal, as they help increase the skin's capacity to retain moisture, leading to a more supple and vibrant complexion.

Clinical studies have consistently supported glycolic acid's role in improving skin appearance. Research indicates significant improvements in skin texture and pigmentation and the visible reduction of wrinkles and fine lines with glycolic acid.

Physiological Effects

  • Exfoliation: Glycolic acid is a powerful exfoliant. It dissolves the bonds between dead skin cells on the skin’s surface, facilitating their removal and revealing newer, healthier skin underneath.
  • Increased Collagen Production: It stimulates collagen production, which is essential for skin elasticity and firmness. This action helps reduce the appearance of fine lines and wrinkles.
  • Enhanced Skin Hydration: Glycolic acid improves the skin's ability to retain moisture, enhancing hydration and a more plump, vibrant skin appearance.
  • Skin Brightening: Removing dead skin cells can brighten the complexion and reduce the appearance of dark spots and hyperpigmentation.
  • Improved Skin Texture: Regular use of glycolic acid can lead to smoother, more even textured skin, making it beneficial for conditions like keratosis pilaris.
  • Acne Treatment: Its exfoliating properties help in unclogging pores, thereby reducing the occurrence of acne breakouts.

Managing Dermatological Conditions

  • Aging Skin: Glycolic acid is widely used in anti-aging products to reduce signs of aging, such as fine lines, wrinkles, and age spots.
  • Acne-Prone Skin: It helps manage acne by exfoliating the skin and removing blockage from pores.
  • Hyperpigmentation: It effectively treats hyperpigmentation by accelerating the removal of hyperpigmented skin cells.
  • Textural Irregularities: Glycolic acid can improve skin texture and is beneficial for treating keratosis pilaris and other conditions of rough skin.
  • Sun-Damaged Skin: It helps rejuvenate sun-damaged skin by accelerating cell turnover and collagen synthesis.

References

  • Bernstein, E. F. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatologic Surgery.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology.
  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology, 35(3), 388-391.
Urea

Urea

Urea, a naturally occurring compound in the skin, is widely recognized in dermatology and skin care for its hydrating and keratolytic properties. It is a component of the skin's natural moisturizing factor (NMF) and is crucial in maintaining skin hydration and barrier function.

In skin care, urea is valued for its dual action: it acts as a humectant, drawing moisture into the skin, and as a keratolytic agent, helping to break down the protein bonds between dead skin cells, leading to smoother and softer skin. This makes it particularly effective in treating dry, rough, and scaly skin conditions such as eczema, psoriasis, and ichthyosis.

Additionally, urea has been shown to have antimicrobial properties and can aid in skin barrier repair, further underscoring its utility in treating various skin conditions.

Physiological Effects

  • Hydration: Urea is a potent humectant, meaning it draws moisture into the skin, significantly improving hydration and maintaining skin moisture balance.
  • Keratolytic Action: Urea has keratolytic properties, helping to break down the bonds between dead skin cells and aiding in the exfoliation of the skin's surface.
  • Skin Barrier Function: Urea enhances the skin's barrier function, helping to prevent moisture loss and protect the skin from external irritants.
  • Soothing Effect: It soothes dry, itchy, and irritated skin, providing relief from various skin conditions.

Managing Dermatological Conditions

  • Dry Skin (Xerosis): Urea is a key ingredient in many moisturizers for treating dry skin due to its excellent hydrating properties.
  • Eczema and Psoriasis: It helps manage symptoms like dryness, scaling, and itching in eczema and psoriasis.
  • Ichthyosis and Keratosis Pilaris: The keratolytic action of urea makes it effective in conditions characterized by excessive skin scaling, such as ichthyosis and keratosis pilaris.
  • Cracked Heels and Calluses: Urea-based creams effectively soften and reduce thickened skin on heels and calluses.
  • Aging Skin: It can improve skin texture and hydration in aging skin.

References

  • Lodén, M. (2003). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology.
  • Pan, M., et al. (2013). Efficacy of topical urea in the treatment of xerosis. American Journal of Clinical Dermatology.
  • Fluhr, J. W., et al. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
  • Grether-Beck, S., Felsner, I., Brenden, H., Kohne, Z., Majora, M., Marini, A., ... & Krutmann, J. (2012). Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. Journal of Investigative Dermatology, 132(6), 1561-1572.
Lactic acid

Lactic acid

Lactic acid, a member of the alpha hydroxy acid (AHA) family, is a well-regarded ingredient in the field of dermatology and skincare for its exfoliating and moisturizing properties. Naturally occurring in sour milk and other fermented products, lactic acid is also produced in the human body and plays a role in various metabolic processes.

In skincare, lactic acid is primarily known for its ability to exfoliate the skin gently. By breaking down the bonds that hold dead skin cells together on the skin's surface, lactic acid helps to promote the shedding of these cells, revealing fresher, brighter skin underneath. This exfoliation process improves skin texture and tone and stimulates cell renewal.

One key advantage of lactic acid over other AHAs is its moisturizing capability. Lactic acid helps increase the skin's natural moisturizing factors (NMF), essential for keeping the skin hydrated. Its unique ability to draw moisture into the skin is particularly beneficial for treating dry and dehydrated skin conditions.

Physiological Effects

  • Exfoliation: A gentle exfoliant that removes dead skin cells from the skin's surface, promoting smooth skin.
  • Moisture Retention: It is a humectant that helps the skin retain moisture, improving hydration and reducing dryness.
  • Collagen Stimulation: Lactic acid can stimulate collagen production in the deeper layers of the skin, aiding in skin firmness and reducing the appearance of fine lines and wrinkles.
  • Skin Brightening: It helps lighten dark spots and even out skin tone, effectively treating hyperpigmentation.
  • pH Balancing: Lactic acid can help balance the skin's natural pH levels, which is beneficial for maintaining a healthy skin barrier.

Managing Dermatological Conditions

  • Aging Skin: Lactic acid's collagen-stimulating and exfoliating properties make it effective in anti-aging treatments, reducing signs of aging like wrinkles and age spots.
  • Acne-Prone Skin: By unclogging pores and removing dead skin cells, lactic acid can help reduce acne breakouts.
  • Dry Skin (Xerosis): Its humectant properties are beneficial in hydrating and relieving dry skin.
  • Hyperpigmentation: Lactic acid treats hyperpigmentation issues, including melasma and sun damage.
  • Keratosis Pilaris: It can help manage keratosis pilaris by exfoliating the excess keratin that blocks hair follicles.

References

  • Smith, W. P. (1996). Epidermal and dermal effects of topical lactic acid. Journal of the American Academy of Dermatology.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology.
  • Stiller, M. J., et al. (1996). Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial. Archives of Dermatology.
  • Rawlings, A. V., Davies, A., Carlomusto, M., Pillai, S., Zhang, K., Kosturko, R., ... & Watson, D. (1996). Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Archives of Dermatological Research, 288(7), 383-390.

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DermExcel™ | Dermdefence SPF 50
DermExcel™ | Dermdefence SPF 50
Dermdefence SPF 50 Dermdefence SPF 50 Dermdefence SPF 50 Dermdefence SPF 50
DermExcel™

Dermdefence SPF 50

Sale priceR 517.00
4.9 / 5.0 from 836 reviews

SIZE: 50 mL

Antioxidant

Antioxidant

anti-aging

anti-aging

DNA repair

DNA repair

sun protection

sun protection

Moisturizing

Moisturizing

A pioneering sunscreen offering superior protection against the sun while preserving your skin's cellular and DNA health. The innovative formula exceeds standard UV protection, guarding against UVA, UVB, damaging infrared rays, and blue light. Offering wide-ranging protection bolsters your skin's restorative abilities, promoting a healthier and more resilient complexion.

Designed to be fragrance-free and anti-comedogenic, Dermdefence SPF 50 ensures no skin irritation or pore clogging, making it an excellent choice for those with skin conditions like Acne, Rosacea, or Eczema. Its lightweight, non-greasy texture provides easy application and rapid absorption, without leaving a white cast.

Dermdefence SPF 50 also serves as a primer, providing a smooth finish for easy makeup application and ensuring a flawless look all day. Dermdefence SPF 50 provides unparalleled sun protection that will shield your skin and nurture its unique needs, maintaining its health and radiance.

Coenzyme Q10

Coenzyme Q10

CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.

Physiological Impact

  • Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
  • Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.

Pharmacological Advantages

  • Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
  • Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.

Biochemical Benefits

  • Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
  • Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Infraguard™

Infraguard™

Infraguard™ is a novel and powerful antioxidant powerhouse designed to protect the skin from the potentially harmful effects of electromagnetic radiation, specifically from 5G networks, blue light, and other environmental stressors. It shields the skin against oxidative stress and inflammation, prevents premature aging, and maintains overall health.

Infraguard® is a multifunctional ingredient that extends beyond traditional sun protection. It addresses the broader spectrum of light-induced skin damage and oxidative stress, provides DNA protection, and offers anti-aging benefits. Its inclusion in the DermExcel sunscreens represents an advanced step in comprehensive skin care, targeting UV rays and the often-overlooked infrared and blue light, ensuring a more holistic approach to maintaining skin health and appearance.

Physiological Effects

  • Protection Against Blue Light and Infrared (IR) Radiation: Infraguard is formulated to shield the skin from the harmful effects of blue light and IR radiation, which can lead to premature skin aging and damage.
  • Antioxidant Properties: It has strong antioxidant capabilities, helping to neutralize free radicals induced by environmental stressors such as pollution, IR, and blue light.
  • Anti-Aging Benefits: By protecting against IR radiation and mitigating oxidative stress, Infraguard helps to prevent signs of aging like wrinkles and loss of skin elasticity.
  • Skin Barrier Protection: Infraguard strengthens the skin's natural barrier, enhancing its resilience against environmental factors.
  • DNA Protection: Infraguard™ aids in shielding the DNA in skin cells from damage caused by environmental aggressors. This is crucial in maintaining the integrity of skin cells and preventing mutations that can lead to skin aging and other skin-related issues.

Managing Dermatological Conditions

  • Preventing Photoaging: Infraguard's ability to protect against IR and blue light makes it beneficial in preventing photoaging, a key concern in modern dermatology. Infrared light can penetrate deeper into the skin than UV rays, potentially leading to increased collagen degradation and skin laxity. Infraguard® helps mitigate these effects.
  • Combatting Environmental Stressors: Its antioxidant properties protect the skin from various environmental pollutants and stressors.
  • Supporting Skin Health: Infraguard contributes to overall skin health by improving the skin's barrier function and providing antioxidant support.
  • Suitability for Diverse Skin Conditions: Given its protective and anti-aging properties, Infraguard is suitable for use in various dermatological conditions, especially environmental damage and aging.

References

  • Kappler, Katharina et al. "Development of an in Vitro Assay to Evaluate the Biological Impact of 5G Technology on Human Skin. Journal of Cosmetics, Dermatological Sciences and Applications, 2022, vol. 12, pp. 100-108. DOI: 10.4236/jcdsa.2022.122009​​.
  • Extensive references cited within the research article including studies on 5G technology, health effects, and skin biology​​.
Broad Spectrum Filters

Broad Spectrum Filters

Tinosorb® M and Tinosorb® S represent sophisticated advancements in sun protection technology.

Tinosorb® M

  • Biochemical Action: A unique UV filter due to its ability to function through absorption, reflection, and scattering of UV rays.
  • Physiological Impact: The triple-action mechanism of Tinosorb® M offers comprehensive sun protection. By mitigating the penetration of both UVA and UVB rays, it significantly reduces the risk of DNA damage, photoaging, and carcinogenesis. Its ability to remain on the skin's surface reduces systemic exposure, making it a safer option with minimal potential for irritation or allergic reactions.

Tinosorb® S

  • Biochemical Action: A broad-spectrum UV filter with a molecular structure that effectively absorbs both UVA and UVB rays. Additionally, it enhances the photostability of other UV filters, making the sunscreen formulation more effective over time.
  • Physiological Impact: By providing extensive UVA and UVB protection, Tinosorb® S plays a crucial role in preventing short-term sun damage like sunburn and long-term risks such as skin aging and skin cancer. Its photostability ensures sustained protection during sun exposure, and its compatibility with other UV filters means it can be used to formulate sunscreens that are both effective and suitable for sensitive skin.
Sunscreen

Sunscreen

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.

Managing Dermatological Conditions

  • Prevention of Sunburn: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
  • Skin Cancer Prevention: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
  • Prevention of Photoaging: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
  • Protection Against Photosensitivity: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
  • Hyperpigmentation and Melasma: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
  • General Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.

References

  • Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
  • Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
  • Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.

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Testimonials

Customer Reviews

Based on 2598 reviews
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(2465)
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(102)
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C
Cornelle Tait
Amazing product!

I love this product! It has improved the appearance of my skin so much!

J
JD
Luxurious Feel, But Pricey Habit!

This serum feels absolutely amazing—silky smooth, lightweight, and absorbs almost instantly, leaving my skin feeling refreshed and hydrated. The texture is so nice that I find myself reaching for more than I probably should, which, given the price, makes this an expensive indulgence. While I love the experience of using it, I do wish a little went a longer way. If budget isn't a concern, it's a fantastic treat. But if you're watching your spending, be prepared for this to become a pricey habit!

M
Maxine Perthel
Amazing Products!

More on the expensive side but great value for money and so worth it!! Quickly saw a big difference in my skin!! Thank you so much for the great service and quality products!

J
Jess Bennett
Inflacin serum

This is my second bottle and now apart of my skin routine. My skin has completely cleared up after a couple of applications.

T
Tammy Coetzee
Dermexcel is best

I am 56 years old and have been using Dermexcel for 4 years already. This quality product not only rescued my skin, but keeps it clean and well looked after.

L
Lynne Brits

Best product I ever used

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