DermExcel™

Follicure

Name: Follicure
Brand: DermExcel™
SKU: DX-FOL
Price: 497.00 ZAR
Availability: InStock

4.9 / 5.0 from 792 reviews

R 497.00

SIZE: 120 mL

healthy scalp

anti-dundruff

↓ inflammation

oil control

Itch Relief

A maximum strength medicated scalp treatment to relieve itching, irritation, redness, flaking, and scaling associated with dandruff and seborrheic dermatitis.

A powerful formula that combines 2% Salicylic acid and 2% Zinc pyrithione for maximum effectiveness and life-changing results.

Our advanced formulation is enriched with Ceramides, fatty acids, and Cholesterol, intelligently combining to repair, strengthen, and revive the skin barrier. This powerhouse blend of potent ingredients supports the dermis in retaining moisture, preventing water loss, and restoring the skin structure, resulting in a healthier, more vibrant complexion.

Zinc Pyrithione, an antifungal, antimicrobial, and antibacterial agent, works by reducing the amount of fungus that triggers inflammation and scaling. Zinc Pyrithione also treats pityrosporum folliculitis (fungal acne) on the face and other body parts.

Salicylic acid gently exfoliates the scalp, removing dead skin cells and excess oil, contributing to dandruff and itchiness. As a result, it unclogs hair follicles, promoting a healthier scalp environment.

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological Effects

Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Role in Managing Dermatological Conditions

Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.

Salicylic Acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Free Gift with Follicure:

Mini Silicone Scalp Massager

USE DURING PREGNANCY

Follicureis safe to use during pregnancy.

SHIPPING

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RETURNS

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Follicure

R 497.00

Dandruff
Seborrheic dermatitis
Itchy and irritated scalp
Inflammation
Acne, body acne and conditions related to yeast / fungal infections
Shaving bumps / Folliculitis
Psoriasis

Active ingredients

Zinc Pyrithione

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Salicylic Acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Full ingredient list

Aqua, Polyethylene Glycol, Coco-Glucoside, Cocoamidopropyl Betaine, Sodium Lauroyl Sarcosinate, Salicylic acid, Zinc Pyrithione, Phenoxyethanol & Ethyl hexyl Glycerin, Acrylates Copolymer, Triethanolamine, Coco-Glucoside & Glyceryl Oleate

Evening

Active Scalp Treatment: Apply Follicure 2 to 3 times per week, depending on the severity of your condition. As your symptoms improve, you may reduce the frequency of use.
Healthy Scalp Maintenance: Apply Follicure to affected or previously affected areas at least once weekly.

1. Apply

Apply to wet hair and scalp

Wet hair allows the product to distribute evenly and work effectively on the scalp.
Take a sufficient amount of Follicure and gently massage it onto the wet scalp, ensuring complete coverage.
Pay particular attention to areas with visible signs of dandruff, itchiness, or irritation.

2. Massage into scalp

Use the fingertips or the included scalp massager to massage Follicure into the scalp with circular motions. This helps to activate the ingredients and promotes better penetration.
Leave Follicure on the scalp for approximately 5 to 10 minutes to allow the active ingredients to work effectively.

3. Rinse

After the designated time, thoroughly rinse hair and scalp with lukewarm water, ensuring that all residue is removed.
It is important to rinse thoroughly, as any remaining product on the scalp may cause irritation or reduce the effectiveness of the treatment.

Usage Frequency

Apply Follicure 2 to 3 times per week, depending on the severity of your condition. As your symptoms improve, you may reduce the frequency of use.
To ensure healthy skin maintenance, apply Follicure to affected areas at least once per week.

Follicure

product benefits

Keratolytic action

Exfoliate dead skin cells that accumulate and become trapped in hair follicles. This leads to the overgrowth of dandruff, which causes Malassezia yeast.

Sebum (oil) regulation

Sebum is an oily substance produced by the sebaceous glands on the scalp. When it is overproduced, it contributes to the development of dandruff.

Anti-Inflammatory

Reduces inflammation associated with acne and folliculitis. It helps soothe irritated skin, alleviating redness and discomfort.

Anti-fungal action

Disrupt the cell membrane of the dandruff-causing Malassezia yeast, which inhibits its growth and reduces its ability to colonize the scalp.

follicure

mode of action

Anti-inflammatory

Inflammation on the scalp contributes to itchiness, redness, and irritation, which are common symptoms of dandruff. Zinc pyrithione reduces inflammation on the scalp, which helps to alleviate these symptoms.
Zinc Pyrithione positively affects the immune system by balancing pro-inflammatory and anti-inflammatory cytokines in the body. Studies published in the Journal of Dermatological Science indicate that Zinc Pyrithione increases the production of anti-inflammatory cytokines in human skin cells. These cytokines are known to be involved in the immune response and are important for regulating inflammation and promoting healing.
Studies further indicate that Zinc Pyrithione significantly reduces the production of the pro-inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha. This action boosts the body's natural defenses against the yeast and reduces the severity of dandruff symptoms.
Cytokine production is a complex process that involves a delicate balance between pro-inflammatory and anti-inflammatory cytokines. Too much or too little cytokine production can lead to problems with inflammation and immune function. Zinc Pyrithione contributes to a healthy balance between inflammation and immune function.
Zinc pyrithione also has direct anti-inflammatory effects on the skin by reducing the production of certain enzymes that contribute to inflammation.

Anti-fungal

Zinc Pyrithione has broad-spectrum antimicrobial activity: It inhibits and reduces the burden of Dandruff-causing Malassezia on the skin and targets gram-positive and gram-negative bacteria and other fungi that cause ringworm, athlete's foot, and jock itch.
Zinc Pyrithione disrupts iron distribution across the yeast wall and effectively starves the yeast of some of the critical processes important in its respiratory function.
Zinc Pyrithione disrupts the yeast's cell membrane, preventing it from proliferating and reproducing. Zinc pyrithione binds to the cell membrane of the yeast and causes damage to its structure, which ultimately leads to cell death.
Zinc pyrithione also interferes with the metabolic processes of the yeast. It disrupts the uptake of essential nutrients and alters the scalp's pH balance, making it more difficult for the yeast to survive and grow.
Zinc Pyrithione penetrates the hair follicle where Malassezia resides and has a unique slow-release ability. It persists in the top layer of skin even after rinsing off the product. Therefore, it imparts long-lasting control and sustained release of anti-yeast coverage and suppression of Malassezia yeast overgrowth.
Yeast, fungi, and bacteria do not develop resistance to Zinc Pyrithione. Consistent application of Zinc Pyrithione results in continuous antimicrobial activity.

Zinc pyrithione

Zinc Pyrithione has broad-spectrum antimicrobial activity:
Not only does it inhibit and reduce the burden of Malassezia on the skin, but it also targets gram-positive and gram-negative bacteria, as well as other fungi that cause ringworm, athlete's foot, and jock itch.
Zinc Pyrithione disrupts iron distribution across the yeast wall and effectively starves the yeast of some of the critical processes important in its respiratory function.
Zinc Pyrithione penetrates the hair follicle where Malassezia resides and has a unique slow-release ability. It persists in the top layer of skin even after rinsing off the product. Therefore, it imparts long-lasting control and sustained release of anti-yeast coverage and suppression of the Malassezia yeast overgrowth.
Yeast, fungi, and bacteria do not develop resistance to Zinc Pyrithione. Consistent application of Zinc Pyrithione will, therefore, result in continuous antimicrobial activity.

Remove dead skin

Salicylic acid exfoliates dead skin cells from the scalp's surface, reducing flakes and dandruff buildup.

Dandruff is often caused by an accumulation of dead skin cells on the scalp. These cells can become trapped in hair follicles and create an environment favorable for Malassezia's growth. This fungus is associated with dandruff.

Salicylic acid helps break down the bonds between dead skin cells, making it easier to remove them from the scalp. This helps reduce the buildup on the scalp, which in turn can reduce the amount of dandruff.

Salicylic acid also has anti-inflammatory properties, which can help to soothe an irritated scalp and reduce itching and flaking. By reducing inflammation and promoting healthy skin renewal, salicylic acid helps create an environment less conducive to Malassezia's growth.

Overall, salicylic acid is an effective treatment for dandruff because it helps to exfoliate dead skin cells, reduce inflammation, and promote healthy skin renewal.

clinical data

These clinical trials and studies provide evidence for the efficacy of salicylic acid in managing dandruff, itchy scalp, and seborrheic dermatitis. Salicylic acid's keratolytic properties enable it to break down dead skin cells, exfoliate the scalp, and reduce flaking and itching, making it a valuable treatment option for these common scalp conditions.

Squire, R. A., & Goode, K. (1984). A randomised, single-blind, single-centre clinical trial to evaluate comparative clinical efficacy of shampoos containing ciclopirox olamine (1.5%) and salicylic acid (3%), piroctone olamine (1%) and salicylic acid (3%) and zinc pyrithione (1%) and salicylic acid (3%) for the treatment of moderate dandruff. Journal of Dermatological Treatment, 5(2), 73-77.
This clinical trial compares the efficacy of shampoos containing salicylic acid in combination with different active ingredients, including ciclopirox olamine, piroctone olamine, and zinc pyrithione. The results indicate that all combinations effectively reduce dandruff symptoms.
Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455-461. This comprehensive review outlines the various dermatological applications of salicylic acid, including its use in treating dandruff and other scalp conditions.
The review emphasizes salicylic acid's keratolytic properties, which help to break down the skin's outer layer and reduce flaking and itching.
Garnacho-Saucedo, G., Salido-Vallejo, R., Moreno-Giménez, J. C., Vélez, A., & Campos-Domínguez, M. (2012). Comparative, open-label, randomized, 6-month trial to assess the efficacy and safety of a 1% zinc pyrithione and 1% salicylic acid shampoo vs. 2% ketoconazole shampoo in the treatment of moderate to severe dandruff. Journal of Dermatological Treatment, 23(5), 362-366.
This randomized trial compares the efficacy and safety of a 1% zinc pyrithione and 1% salicylic acid shampoo with a 2% ketoconazole shampoo in treating moderate to severe dandruff. The study shows that the combination of zinc pyrithione and salicylic acid provides effective and safe treatment for these conditions.
Ranganathan, S., & Mukhopadhyay, T. (2010). Dandruff: The most commercially exploited skin disease. Indian Journal of Dermatology, 55(2), 130-134.
This review article discusses various treatments for dandruff, including salicylic acid. The authors emphasize that salicylic acid acts as an exfoliant and helps to remove scales and flakes, effectively managing dandruff and associated symptoms.

indications for Follicure

Irritated Scalp
Itchy Scalp
Folliculitis
Seborrheic Dermatitis
Dandruff

Medicated scalp treatment treating dandruff, soothes irritation, and tames seborrheic dermatitis.

Targets Malassezia Yeast: Zinc pyrithione is particularly effective against Malassezia yeast, a fungus commonly found on the skin and scalp. This yeast can proliferate excessively, leading to dandruff and seborrheic dermatitis.

Disrupts Fungal Cell Membranes: ZPT works by disrupting the fungus's cell membranes, inhibiting its growth and survival. This action reduces the fungal population on the skin, alleviating symptoms associated with overgrowth.

Broad-Spectrum Activity: Zinc pyrithione also possesses antibacterial properties that are effective against various bacteria that can contribute to skin irritation and infection. Reducing bacterial load helps prevent secondary infections and promotes skin healing.

Inhibits Bacterial Enzyme Systems: It interferes with enzyme systems within bacterial cells, leading to their death. This mechanism helps maintain skin flora balance and prevents conditions like acne and folliculitis.

Cleansers

testimonials

In-house Salon

This range of products are the best. It's like having a salon treatment in the comfort of your own home every day. Would recommend it to all

Pore Control Cleanser

Absolutely love this product! I will never use anything other than this cleanser ever again! I have struggled with my skin for many years, and tried various products. This cleanser cleans, refreshes, moisturize and tightens pores.