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DermExcel™ | Litaderm Serum
DermExcel™ | Litaderm Serum
DermExcel™ | Litaderm Serum
Litaderm Serum: Trial Litaderm Serum: Trial Litaderm Serum: Trial Litaderm Serum: Trial
DermExcel™

Litaderm Serum: Trial

4.9 / 5.0 from 2628 reviews
Sale price R 200.00

SIZE: 5 mL

Even Skin Tone

Even Skin Tone

Moisturizing

Moisturizing

anti-redness

anti-redness

anti-aging

anti-aging

↓ inflammation

↓ inflammation

A scientifically formulated correction serum that targets various skin concerns, promoting a healthy and radiant complexion. Its powerful blend of multi-tasking active ingredients is supported by peer-reviewed medical literature, ensuring its effectiveness in improving and preventing hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation.

The key active ingredients in Litaderm Serum work synergistically to deliver remarkable benefits. Niacinamide, at 10% concentration, enhances skin appearance by reducing hyperpigmentation, promoting even skin tone, and combating inflammation related to acne and rosacea. At 1%, Bakuchiol provides targeted treatment for signs of aging and skin damage, supporting a youthful complexion. With a potent 10% concentration, Azelaic acid reduces hyperpigmentation, redness, and inflammation, contributing to overall healthier skin. Arbutin, comprising 4% of the formula, further aids in correcting hyperpigmentation and promoting a more even complexion.

With its carefully selected ingredients, Litaderm Serum offers a dynamic formulation that comprehensively addresses various skin concerns. Supported by scientific evidence, this serum effectively targets hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation. Regularly using Litaderm Serum improves skin tone, texture, and overall radiance, resulting in healthy, radiant, and even-toned skin. Experience the benefits of this targeted approach to achieve a revitalized and rejuvenated appearance.

Niacinamide
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects
  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions
  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Azelaic acid
Azelaic acid

Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.

Physiological Effects
  • Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
  • Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
  • Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
  • Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.

Role in Managing Dermatological Conditions
  • Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
  • Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
  • Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.

References
  • Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
  • Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
  • Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
  • Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
  • Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
Alpha Arbutin
Alpha Arbutin

Alpha Arbutin is a derivative of hydroquinone and a biosynthetic active ingredient. Its primary action is inhibiting tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. Alpha Arbutin effectively reduces melanin production in the skin by inhibiting tyrosin activity. This gradually lightens hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.

One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.

In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.

Physiological Effects
  • Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
  • Even Skin Tone: Regular use of alpha arbutin can lead to a more even skin tone overall, reducing the appearance of age spots and hyperpigmentation.
  • Reduced Skin Discoloration: It effectively reduces the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
  • Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.

Role in Managing Dermatological Conditions
  • Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
  • Skin Brightening: Provide a more radiant and uniform skin tone.
  • Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
Bakuchiol
Bakuchiol

Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.

Physiological Effects
  • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
  • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
  • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
  • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
  • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.

Role in Managing Dermatological Conditions
  • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
  • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
  • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
  • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.

References
  • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
  • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
  • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
Litaderm Serum: Trial Litaderm Serum: Trial Litaderm Serum: Trial Litaderm Serum: Trial
  • Aging Skin: Promote cell renewal and improve skin elasticity to target early signs of aging, including fine lines and wrinkles.
  • Hyperpigmentation: Specifically formulated to improve and prevent hyperpigmentation, helping to reduce the appearance of dark spots, uneven skin tone, and discoloration.
  • Melasma: Indicated for individuals who have developed patches of facial skin discoloration due to hormonal changes such as pregnancy or birth control use.
  • Redness and Inflammation: The active ingredients work synergistically to calm inflammation and reduce redness, promoting a more balanced and even-toned complexion.
  • Skin Damage: Litaderm Serum boosts skin health and supports skin regeneration, Which is indicated for individuals with skin damage, possibly due to environmental factors like sun exposure.
  • Acne: Reduce inflammation associated with acne, regulate sebum production, and minimize the appearance of blemishes, contributing to clearer and healthier skin.
  • Rosacea: Reduce the visible signs of rosacea, including redness and enlarged blood vessels.
  • Dull Lifeless Skin: Reduces melanin production, leading to a more even skin tone.
  • Overall Skin Health: Nourishes and rejuvenates the skin, promoting a healthier and youthful complexion.

Morning & / or Evening
  • Normal, Oily, and Combination skin types: Apply in the evening.
  • Dry skin types: Apply in the morning and / or evening.
  • Frequency: Every day or as per your Dermal Diagnosis regimen instructions.

1. Cleanse
  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply
  • Take a small amount of serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.

3. Wait
  • Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes 1-2 minutes.

Important notes
  • Clean skin: The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
  • Damp skin: After cleansing your face, don't completely dry your skin; leave it slightly damp. The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum.
  • Less is more: serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.

Active ingredients
  • Niacinamide
    • Niacinamide

    Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

    One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

    Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
    • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
    • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
    • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
    • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
    • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
    • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
    • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
    • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
    • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
    • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
    • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
    • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
  • Azelaic acid
    • Azelaic acid

    Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

    One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

    Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
    • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
    • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
    • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
    • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
    • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
    • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
    • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
    • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
    • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
    • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
    • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
    • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
  • Alpha Arbutin
    • Alpha Arbutin

    Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

    One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

    Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
    • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
    • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
    • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
    • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
    • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
    • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
    • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
    • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
    • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
    • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
    • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
    • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
  • Bakuchiol
    • Bakuchiol

    Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.

    One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.

    Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
    • Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
    • Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
    • Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
    • Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
    • Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
    • Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
    • Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
    • Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
    • Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
    • Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
    • Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
    • Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.

Full ingredient list

    Aqua, Macrogol, Azelaic acid, Nicotinamide, Glycerine, Arbutin, Jojoba Oil, Bakuchiol, Isostearyl Alcohol · Butylene Glycol Cocoate Ethylcellulose, Butylene glycol, Ceteth-20 · Cetyl Alcohol, Glyceryl Stearate, Steareth-20, C12-15 Alkane, Phenylpropanol, Propanediol, Caprylyl Glycol, Tocopherol

DermExcel™ | Litaderm Serum
Litaderm Serum: Trial Sale priceR 200.00

Litaderm Serum: Trial

product benefits

Skin barrier enhancement
Skin barrier enhancement

Stimulate barrier lipids synthesis, improving skin elasticity to ensure a robust defense against environmental damage.

Boost Collagen Production
Boost Collagen Production

Restore skin structure by stimulating fibroblast activity and supporting the synthesis of new collagen fibers, improving skin firmness and elasticity.

Anti-Aging
Anti-Aging

Target aging at the cellular level, increasing skin regeneration, reducing oxidative stress, and enhancing skin firmness and elasticity for a rejuvenated appearance.

Anti-inflammatory
Anti-inflammatory

Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.

Moisturizing
Moisturizing

Augment the skin's water-binding capacity, promote barrier repair, and deliver deep, lasting moisture for improved skin comfort and appearance.

Anti-Microbial
Anti-Microbial

Manage microbial activity by inhibiting the growth of pathogenic bacteria, balancing the skin's microbiome, and reducing the risk of infections and inflammation.

Rosacea Relief
Rosacea Relief

Target rosacea symptoms by modulating inflammatory pathways, enhancing skin hydration, and reducing the appearance of erythema and visible blood vessels.

Pigmentation treatment
Pigmentation treatment

Diminishes hyperpigmentation by targeting all the pathways involved in melanin synthesis and accelerating the removal of pigmented cells, significantly improving skin tone uniformity and luminosity.

Litaderm serum

mode of action

indications for Litaderm Serum: Trial

Aging Skin
Pigmentation
Dry Skin
Dull & Lifeless Skin
Rosacea / Red Skin
Acne / Breakouts
Enlarged Pores
Rough Skin Texture
DermExcel™ | Litaderm Serum: Trial

Diminish hyperpigmentation by targeting the pathways involved in melanin synthesis and accelerating the removal of pigmented cells, resulting in clear and luminous skin.

litaderm action on

all pigmentation phases

before melanin production

during melanin production

after melanin production

azelaic acid

niacinamide

arbutin

bakuchiol

before melanin production

azelaic acid

niacinamide

arbutin

bakuchiol

during melanin production

azelaic acid

arbutin

bakuchiol

after melanin production

niacinamide

Litaderm Serum: Trial

pigmentation

treatment steps

STEP 1 - Block Alpha Melanocyte Stimulating Hormone

STEP 1 - Block Alpha Melanocyte Stimulating Hormone

Bakuchiol

α-MSH activates the hyperpigmentation process by binding to receptors that upregulate tyrosinase expression.

Bakuchiol blocks the melanocyte-stimulating hormone and tyrosinase activation.

Step 2 - Block Tyrosinase activity and functionality

Step 2 - Block Tyrosinase activity and functionality

Azelaic acid and Arbutin

Inhibiting tyrosinase, the crucial enzyme for the initial stages of melanin synthesis, is vital for effective pigmentation treatment.

Azelaic acid & Arbutin block tyrosinase catalytic activity and functionality.

Step 3 - Inhibit melanosome transfer to skin cells

Step 3 - Inhibit melanosome transfer to skin cells

Niacinamide

Niacinamide disrupts the transfer of pigment-containing melanosomes to skin cells. This action effectively reduces hyperpigmentation by limiting the distribution of melanin on the skin's surface.

Niacinamide inhibits the transfer of pigment to skin cells.

Step 4 - Destroy damaged melanocytes

Step 4 - Destroy damaged melanocytes

Azelaic acid

Azelaic acid prevents abnormal hyperactive melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes. It has no cytotoxic effect on normal, healthy-functioning melanocytes.

Azelaic acid destroys abnormal functioning melanocytes.

Rosacea

Stages and treatment objectives

The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.

Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

Normal Skin

Normal Skin
  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.

Phase 1

Phase 1
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

Phase 2

Phase 2
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.

Phase 3

Phase 3
  • The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

LITADERM SERUM MODE OF ACTION

rosacea treatment

testimonials

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Anonymous
Collagen Serum

Wonderful product and also great for someone with sensitive and dry skin. Provides deep hydration.

A
Annelize De Beer
Great product

Great product, can see the difference after 3 months use

M
Martie Kotze
Life and skin changing products!

I've ordered the Litaderm serum for the second time-fantastic for pigmentation and even skin tone. I've struggled with my skin all my life-mainly because of picking at any little visible bump or blackhead. Since using Dermal Health my skin is beautiful, smooth and hydrated. There is literally nothing to pick at, even if I look for something close up! It has given me so much confidence regarding my skin-I will never use any other products ever. Thank you Dermal Health-it really is life changing products and a little really goes a long way!! 🙌🏻

M
Martine Moore
Litaderm Serum

These products are incredible! At first I was worried as I have very sensitive skin but the change since using them is out of this world. My pigmentation is almost “gone.” I would highly recommend to anyone needing a good skin care product.

C
Charne Wyman

Retinol Serum: Trial

e
elizabeth
Litaderm

Love all your products. Using it for years now. Only place where you order and get your delivery super fast. Thank you for the amazing products and service.

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