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SIZE: 30 mL
Even Skin Tone
Moisturizing
anti-redness
anti-aging
↓ inflammation
A scientifically formulated correction serum that targets various skin concerns, promoting a healthy and radiant complexion. Its powerful blend of multi-tasking active ingredients is supported by peer-reviewed medical literature, ensuring its effectiveness in improving and preventing hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation.
The key active ingredients in Litaderm Serum work synergistically to deliver remarkable benefits. Niacinamide, at 10% concentration, enhances skin appearance by reducing hyperpigmentation, promoting even skin tone, and combating inflammation related to acne and rosacea. At 1%, Bakuchiol provides targeted treatment for signs of aging and skin damage, supporting a youthful complexion. With a potent 10% concentration, Azelaic acid reduces hyperpigmentation, redness, and inflammation, contributing to overall healthier skin. Arbutin, comprising 4% of the formula, further aids in correcting hyperpigmentation and promoting a more even complexion.
With its carefully selected ingredients, Litaderm Serum offers a dynamic formulation that comprehensively addresses various skin concerns. Supported by scientific evidence, this serum effectively targets hyperpigmentation, melasma, redness, acne, rosacea, premature aging, and pigmentation. Regularly using Litaderm Serum improves skin tone, texture, and overall radiance, resulting in healthy, radiant, and even-toned skin. Experience the benefits of this targeted approach to achieve a revitalized and rejuvenated appearance.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Azelaic acid
Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.
Physiological Effects
- Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
- Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
- Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
- Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.
Managing Dermatological Conditions
- Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
- Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
- Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.
References
- Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
- Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
- Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
- Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
- Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
Alpha Arbutin
Alpha Arbutin is a derivative of hydroquinone and a biosynthetic active ingredient. Its primary action is inhibiting tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. Alpha Arbutin effectively reduces melanin production in the skin by inhibiting tyrosin activity. This gradually lightens hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.
One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.
In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.
Physiological Effects
- Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
- Even Skin Tone: Regular use of alpha arbutin can lead to a more even skin tone overall, reducing the appearance of age spots and hyperpigmentation.
- Reduced Skin Discoloration: It effectively reduces the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
- Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.
Managing Dermatological Conditions
- Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
- Skin Brightening: Provide a more radiant and uniform skin tone.
- Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
Bakuchiol
Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.
One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.
Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
Physiological Effects
- Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
- Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
- Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
- Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
- Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
Managing Dermatological Conditions
- Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
- Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
- Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
- Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
References
- Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
- Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
- Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
SHIPPING
- Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
- Where We Ship From: Orders are dispatched from our facilities in Pretoria.
- Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
- When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
- Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.
For any shipping inquiries, our customer service team is ready to assist.
RETURNS
Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.
If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.
Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.
Feel as confident in us as we want you to feel in your skin.
SECURE PAYMENT
Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.
If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.
Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.
Feel as confident in us as we want you to feel in your skin.

Choose options


- Aging Skin: Promote cell renewal and improve skin elasticity to target early signs of aging, including fine lines and wrinkles.
- Hyperpigmentation: Specifically formulated to improve and prevent hyperpigmentation, helping to reduce the appearance of dark spots, uneven skin tone, and discoloration.
- Melasma: Indicated for individuals who have developed patches of facial skin discoloration due to hormonal changes such as pregnancy or birth control use.
- Redness and Inflammation: The active ingredients work synergistically to calm inflammation and reduce redness, promoting a more balanced and even-toned complexion.
- Skin Damage: Litaderm Serum boosts skin health and supports skin regeneration, Which is indicated for individuals with skin damage, possibly due to environmental factors like sun exposure.
- Acne: Reduce inflammation associated with acne, regulate sebum production, and minimize the appearance of blemishes, contributing to clearer and healthier skin.
- Rosacea: Reduce the visible signs of rosacea, including redness and enlarged blood vessels.
- Dull Lifeless Skin: Reduces melanin production, leading to a more even skin tone.
- Overall Skin Health: Nourishes and rejuvenates the skin, promoting a healthier and youthful complexion.
- Normal, Oily, and Combination skin types: Apply in the evening.
- Dry skin types: Apply in the morning and / or evening.
- Frequency: Every day or as per your Dermal Diagnosis regimen instructions.
- Start with clean and dry skin.
- Use your DermExcel cleanser to remove dirt and excess oil from your skin.
- Take a small amount of serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
- Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.
- Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes 1-2 minutes.
- Clean skin: The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
- Damp skin: After cleansing your face, don't completely dry your skin; leave it slightly damp. The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum.
- Less is more: serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.
Active ingredients
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
- Anti-Inflammatory Properties: Azelaic acid reduces inflammation, effectively treating inflammatory skin conditions like acne and rosacea.
- Antimicrobial Action: It possesses antimicrobial properties that target acne-causing bacteria (Propionibacterium acnes), helping to reduce acne outbreaks.
- Keratolytic Effects: It helps unclog pores and reduce the formation of comedones (black and whiteheads) by normalizing the shedding of skin cells.
- Depigmenting Agent: Azelaic acid effectively treats hyperpigmentation disorders, including melasma, as it inhibits tyrosinase, an enzyme involved in melanin production.
- Acne: Azelaic acid inhibits the proliferation of acne-causing bacteria on the skin’s surface, thereby reducing bacterial growth and inflammation. Its antibacterial activity is primarily against Propionibacterium acnes, a key bacterium involved in the development of acne. Furthermore, azelaic acid helps unclog pores and reduce skin cell buildup, effectively treating mild to moderate acne.
- Rosacea: Azelaic acid's anti-inflammatory action helps to reduce redness and swelling associated with rosacea. In addition, azelaic acid's ability to reduce keratinization (the process by which skin cells become more fibrous and less flexible) contributes to its effectiveness in this condition.
- Pigmentation: Azelaic acid effectively treats melasma and post-inflammatory hyperpigmentation by inhibiting tyrosinase, an enzyme in melanin production. This helps to reduce the formation of excess pigment and can lead to a more even skin tone.
- Fitton, A., & Goa, K. L. (1991). Azelaic Acid. Drugs.
- Gollnick, H., & Schramm, M. (1998). Topical drug treatment in acne. Dermatology.
- Passeron, T., et al. (2019). Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a low-dose retinoid. G Ital Dermatol Venereol.
- Wolf, J. E., Kerrouche, N., & Arsonnaud, S. (2006). Efficacy and safety of once-daily metronidazole 1% gel compared with twice-daily azelaic acid 15% gel in the treatment of rosacea. Cutis, 77(4 Suppl), 3-11.
- Hollinger, J. C., Angra, K., & Halder, R. M. (2018). Are natural ingredients effective in the management of hyperpigmentation? A systematic review. The Journal of clinical and aesthetic dermatology, 11(2), 28.
- Melanin Inhibition: Alpha Arbutin works by inhibiting tyrosinase, the enzyme responsible for melanin production in the skin. This action reduces the formation of melanin, leading to a lightening of skin pigmentation.
- Even Skin Tone: Regular use of alpha arbutin can lead to a more even skin tone overall, reducing the appearance of age spots and hyperpigmentation.
- Reduced Skin Discoloration: It effectively reduces the appearance of dark spots and areas of hyperpigmentation, such as those caused by acne, sun damage, or hormonal changes.
- Safer Alternative to Hydroquinone: While structurally similar to hydroquinone, alpha arbutin is a safer option with a lower risk of side effects.
- Hyperpigmentation: Alpha arbutin treats melasma, sun spots, and post-inflammatory hyperpigmentation from acne.
- Skin Brightening: Provide a more radiant and uniform skin tone.
- Anti-Aging: Reduce the appearance of age-related spots and uneven skin tone.
- Retinol-like Function: Bakuchiol mimics the actions of retinol, stimulating collagen production. This helps reduce the appearance of fine lines and wrinkles and improves skin elasticity.
- Antioxidant Properties: It offers antioxidant benefits, protecting the skin from oxidative stress and damage caused by environmental factors like UV radiation.
- Anti-inflammatory Effects: Bakuchiol has anti-inflammatory properties, which can help soothe the skin and reduce redness and irritation.
- Improved Skin Tone and Texture: Regular use of bakuchiol can improve skin tone and texture, making it smoother and more even.
- Acne Management: Bakuchiol's antibacterial properties and ability to regulate sebum production make it effective in managing acne.
- Aging Skin: Bakuchiol is popular in anti-aging skincare because it stimulates collagen production and reduces signs of aging.
- Sensitive Skin: As a gentler alternative to retinol, it is suitable for sensitive skin types that cannot tolerate traditional retinoids.
- Acne-Prone Skin: Its antibacterial and anti-inflammatory properties are beneficial in acne treatments.
- Hyperpigmentation: Bakuchiol can help treat hyperpigmentation, enhance skin radiance, and reduce dark spots.
- Chaudhuri, R. K., & Bojanowski, K. (2014). Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science.
- Dhaliwal, S., et al. (2019). Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology.
- Sivamani, R. K., et al. (2019). Clinical efficacy of a bakuchiol, niacinamide and zinc pyrithione formulation in facial sebum control and mild acne. Journal of Cosmetic Dermatology.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
Managing Dermatological Conditions
References
Azelaic acid
Azelaic acid, a naturally occurring dicarboxylic acid, is an effective ingredient in dermatological treatments, particularly for acne, rosacea, and hyperpigmentation, with antimicrobial and anti-inflammatory properties.
Physiological Effects
Managing Dermatological Conditions
References
Alpha Arbutin
Alpha Arbutin is a derivative of hydroquinone and a biosynthetic active ingredient. Its primary action is inhibiting tyrosinase, a key enzyme involved in the synthesis of melanin, the pigment responsible for skin color. Alpha Arbutin effectively reduces melanin production in the skin by inhibiting tyrosin activity. This gradually lightens hyperpigmented areas, such as age spots, melasma, and scars, resulting in a more even skin tone.
One of the significant advantages of Alpha Arbutin over other skin-lightening agents is its safety profile. Unlike hydroquinone, which has been associated with potential side effects and is restricted in many countries, Alpha Arbutin is considered safe and less irritating to the skin, even at higher concentrations. This makes it a suitable ingredient for all skin types, including sensitive skin.
In addition to its skin-lightening properties, Alpha Arbutin has also shown antioxidant effects, helping to protect the skin from oxidative stress caused by environmental factors like UV radiation and pollution.
Physiological Effects
Managing Dermatological Conditions
Bakuchiol
Bakuchiol's mechanism of action is similar to retinol's; it stimulates collagen production and accelerates cell turnover, improving skin texture and tone. It also helps reduce the appearance of fine lines, wrinkles, and hyperpigmentation, making it an effective ingredient in anti-aging skincare products.
One of the key advantages of bakuchiol over traditional retinol is its gentleness on the skin. Retinol is known for potential side effects like dryness, redness, and irritation, particularly in sensitive skin or when used in high concentrations. Bakuchiol, however, is far less irritating. In addition to its anti-aging properties, bakuchiol exhibits antioxidant and anti-inflammatory properties, further contributing to its skin benefits. It helps protect the skin from oxidative stress and can soothe it, reducing redness and inflammation.
Bakuchiol's retinol-like effects and its antioxidant, anti-inflammatory, and antibacterial properties make it an effective ingredient for various skin concerns, especially for those seeking natural alternatives in anti-aging and acne treatment.
Physiological Effects
Managing Dermatological Conditions
References
Full Ingredient list
Aqua, Macrogol, Azelaic acid, Nicotinamide, Glycerine, Arbutin, Jojoba Oil, Bakuchiol, Isostearyl Alcohol · Butylene Glycol Cocoate Ethylcellulose, Butylene glycol, Ceteth-20 · Cetyl Alcohol, Glyceryl Stearate, Steareth-20, C12-15 Alkane, Phenylpropanol, Propanediol, Caprylyl Glycol, Tocopherol
Litaderm Serum
product benefits
Skin barrier enhancement
Stimulate barrier lipids synthesis, improving skin elasticity to ensure a robust defense against environmental damage.
Boost Collagen Production
Restore skin structure by stimulating fibroblast activity and supporting the synthesis of new collagen fibers, improving skin firmness and elasticity.
Anti-Aging
Target aging at the cellular level, increasing skin regeneration, reducing oxidative stress, and enhancing skin firmness and elasticity for a rejuvenated appearance.
Anti-inflammatory
Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.
Moisturizing
Augment the skin's water-binding capacity, promote barrier repair, and deliver deep, lasting moisture for improved skin comfort and appearance.
Anti-Microbial
Manage microbial activity by inhibiting the growth of pathogenic bacteria, balancing the skin's microbiome, and reducing the risk of infections and inflammation.
Rosacea Relief
Target rosacea symptoms by modulating inflammatory pathways, enhancing skin hydration, and reducing the appearance of erythema and visible blood vessels.
Pigmentation treatment
Diminishes hyperpigmentation by targeting all the pathways involved in melanin synthesis and accelerating the removal of pigmented cells, significantly improving skin tone uniformity and luminosity.
Indications for Litaderm Serum
Pigmentation
Dry Skin
Dull & Lifeless Skin
Rosacea / Red Skin
Acne / Breakouts
Enlarged Pores
Rough Skin Texture
Litaderm serum
mode of action
Pigmentation Treatment
AZELAIC ACID
- Stops tyrosinase activity, the key enzyme responsible for melanin production, to reduce hyperpigmentation.
- Prevents DNA damage caused by oxidative stress, reducing the risk of pigmentation exacerbation.
- Destroys hyperactive melanocytes, targeting the root cause of abnormal pigmentation.
______
NIACINAMIDE
- Prevents melanosome transfer from melanocytes to keratinocytes, effectively reducing the spread of pigment to surrounding skin cells.
- Protects DNA from oxidative damage through its potent antioxidant activity, helping to prevent pigmentation-related damage.
______
ARBUTIN
- Inhibits tyrosinase activity, preventing the formation of melanin.
- Interferes with the maturation of melanosomes, halting the pigmentation process before it progresses.
______
BAKUCHIOL
- Blocks the melanocyte-stimulating hormone (MSH) from initiating the pigmentation process.
- Inhibits tyrosinase activity and downregulates its gene transcription, reducing melanin synthesis.
- Protects against DNA damage caused by environmental stressors through antioxidant activity.
Anti-Inflammatory
AZELAIC ACID
- Modulates inflammatory pathways by inhibiting overactive cytokines, reducing redness and irritation.
- Acts as an anti-keratinizing agent, inhibiting abnormal keratinocyte proliferation, which helps prevent bumps and skin thickening often associated with inflammatory conditions.
______
NIACINAMIDE
- Reduces redness and irritation by inhibiting pro-inflammatory messengers like cytokines.
- Enhances the skin's resilience by calming inflamed skin and preventing flare-ups triggered by environmental stressors.
______
BAKUCHIOL
- Suppresses pro-inflammatory markers and controls leukocyte activity, calming skin prone to irritation and redness.
- Reduces keratinocyte hyperproliferation, preventing clogged pores and inflammatory lesions.
Microbial Control
AZELAIC ACID
- Exhibits bacteriostatic activity against both aerobic and anaerobic bacteria, including C. acnes.
- Reduces bacterial overgrowth, limiting the inflammation caused by microbial activity.
______
NIACINAMIDE
- Activates antimicrobial peptides in the skin, providing broad-spectrum protection against pathogenic bacteria.
- Balances the microbiome by reducing sebum production, limiting bacteria’s nutrient source.
______
BAKUCHIOL
- Demonstrates antibacterial activity against Gram-positive and Gram-negative bacteria, restoring microbial balance on the skin.
- Reduces sebaceous gland activity, indirectly decreasing bacterial growth in clogged pores.
Anti-Aging
AZELAIC ACID
- Protects against the breakdown of collagen and elastin through its anti-inflammatory and antioxidant properties.
______
NIACINAMIDE
- Stimulates collagen synthesis, improving skin elasticity and firmness.
- Prevents the degradation of collagen and elastin fibers through antioxidant activity, reducing signs of aging.
______
BAKUCHIOL
- Mimics retinol in its ability to activate key anti-aging genes that stimulate collagen production and promote skin cell turnover.
- Improves skin tone, radiance, and brightness by enhancing skin renewal processes.
- Strengthens the skin barrier, further protecting against environmental damage that accelerates aging.
Enhance Skin Barrier & Hydration
NIACINAMIDE
- Enhances lipid synthesis, strengthening the skin barrier and reducing transepidermal water loss (TEWL).
- Repairs and fortifies the stratum corneum, enhancing hydration levels and improving skin resilience against environmental aggressors.
- Promotes a smoother, more supple texture for healthier-looking skin.
______
ARBUTIN
- Provides subtle hydration while supporting the action of other barrier-strengthening ingredients.
______
BAKUCHIOL
- Supports barrier repair by improving hydration levels and reducing moisture loss.
- Reinforces skin integrity by promoting skin renewal and strengthening the extracellular matrix.
rosacea treatment
- Anti-Inflammatory: Reduces inflammation that contributes to redness, breakouts, and skin damage.
- Anti-Microbial: Exhibits bacteriostatic activity against both aerobic and anaerobic bacteria, limiting bacterial growth.
- Antioxidant: Protects skin by preventing DNA damage and reducing the activation of inflammatory enzymes.
- Anti-Keratinizing: Inhibits the abnormal multiplication of skin cells (keratinocytes), reducing clogged pores and irritation.
- Sebum Regulator: Controls sebum overproduction, minimizing bacterial growth and inflammation.
- Anti-Inflammatory: Calms redness and irritation by inhibiting inflammatory messengers.
- Anti-Microbial: Activates the skin’s anti-microbial peptides, offering long-lasting protection against bacteria.
- Sebum Regulator: Reduces sebum production to prevent pore congestion and bacterial proliferation.
- Antioxidant: Shields skin from oxidative stress by preventing DNA damage and inflammatory enzyme activation.
- Anti-Inflammatory: Suppresses pro-inflammatory cytokines and regulates leukocyte activity, reducing redness and swelling.
- Anti-Bacterial: Demonstrates significant antibacterial effects against both Gram-positive and Gram-negative bacteria.
- Anti-Keratinizing: Prevents the abnormal proliferation of keratinocytes, helping to calm and balance the skin.
- Sebum Regulator: Reduces sebaceous gland activity, lowering oil production and minimizing pore clogging.
azelaic acid
- Anti-Inflammatory: Reduces inflammation that contributes to redness, breakouts, and skin damage.
- Anti-Microbial: Exhibits bacteriostatic activity against both aerobic and anaerobic bacteria, limiting bacterial growth.
- Antioxidant: Protects skin by preventing DNA damage and reducing the activation of inflammatory enzymes.
- Anti-Keratinizing: Inhibits the abnormal multiplication of skin cells (keratinocytes), reducing clogged pores and irritation.
- Sebum Regulator: Controls sebum overproduction, minimizing bacterial growth and inflammation.
niacinamide
- Anti-Inflammatory: Calms redness and irritation by inhibiting inflammatory messengers.
- Anti-Microbial: Activates the skin’s anti-microbial peptides, offering long-lasting protection against bacteria.
- Sebum Regulator: Reduces sebum production to prevent pore congestion and bacterial proliferation.
- Antioxidant: Shields skin from oxidative stress by preventing DNA damage and inflammatory enzyme activation.
bakuchiol
- Anti-Inflammatory: Suppresses pro-inflammatory cytokines and regulates leukocyte activity, reducing redness and swelling.
- Anti-Bacterial: Demonstrates significant antibacterial effects against both Gram-positive and Gram-negative bacteria.
- Anti-Keratinizing: Prevents the abnormal proliferation of keratinocytes, helping to calm and balance the skin.
- Sebum Regulator: Reduces sebaceous gland activity, lowering oil production and minimizing pore clogging.
litaderm action on
all pigmentation phases
before melanin production
during melanin production
after melanin production
azelaic acid
niacinamide
arbutin
bakuchiol
before melanin production
azelaic acid
niacinamide
arbutin
bakuchiol
during melanin production
azelaic acid
arbutin
bakuchiol
after melanin production
niacinamide
pigmentation
treatment steps
Bakuchiol
α-MSH activates the hyperpigmentation process by binding to receptors that upregulate tyrosinase expression.
Azelaic acid and Arbutin
Inhibiting tyrosinase, the crucial enzyme for the initial stages of melanin synthesis, is vital for effective pigmentation treatment.
Niacinamide
Niacinamide disrupts the transfer of pigment-containing melanosomes to skin cells. This action effectively reduces hyperpigmentation by limiting the distribution of melanin on the skin's surface.
Azelaic acid
Azelaic acid prevents abnormal hyperactive melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes. It has no cytotoxic effect on normal, healthy-functioning melanocytes.
Rosacea
Stages and treatment objectives
The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.
In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.
Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.
Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.
- Healthy skin with a perfect balance between normal microflora and skin receptors.
- Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
- These receptors should not trigger an immune response by binding to normal microflora.
- PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
- PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
- Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
- Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.
- The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.
Testimonials
With so many products available on the market it’s difficult to choose, which is why I was so excited to see the trial sizes available from Dermexcel! From the first application I could already feel tightening & smoothing of my skin, within a week my pores were becoming unclogged, my skin was definitely smoother & more even tones & the white heads I’d been having a problem with were starting to disappear. Though the products are a little on the pricey side for me, they are worth it in the results that were starting to show! I have ordered & just received my next order.
Best Serum ever. Lasts so long and makes my skin feel super soft.
Serum is amazing!!
Litaderm Serum
I absolutely love all of the trial products I bought. I can definitely see an improvement in my skin. My pores look so much better, and I have no more oily skin. At 50, I can see improvement I love the products. My skin is feeling soft and refreshed.
I love this product! It has improved the appearance of my skin so much!
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