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DermExcel™ | Inflacin Serum
DermExcel™ | Inflacin Serum
DermExcel™ | Inflacin Serum
DermExcel™ | Inflacin Serum
DermExcel™ | Inflacin Serum
Inflacin Serum: Trial Inflacin Serum: Trial Inflacin Serum: Trial Inflacin Serum: Trial
DermExcel™

Inflacin Serum: Trial

4.9 / 5.0 from 2589 reviews
Sale priceR 135.00

SIZE: 5 mL

Unclog Pores

Unclog Pores

↓ Sebum

↓ Sebum

Anti-Acne

Anti-Acne

↓ inflammation

↓ inflammation

anti-aging

anti-aging

A medical-grade treatment with a potent blend of anti-inflammatory and acne-combating ingredients to address skin issues in oily, acne-prone, and combination skin types. The formulation prioritizes preserving skin hydration while eliminating skin concerns like pimples and blackheads.

The serum's composition includes Salicylic acid, known for its proficiency in unclogging pores and reducing acne-related inflammation. Zinc PCA is critical in regulating sebum production and minimizing oily skin complications. Niacinamide shrinks enlarged pores and alleviates inflammation related to acne and rosacea. Lastly, Retinol stimulates cell turnover, aids in the fight against premature aging, and enhances overall skin texture and tone.

As a holistic approach, Inflacin Serum reduces current skin issues and aims to prevent future skin complications, thus promoting a healthier skin condition.

Niacinamide
Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects
  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions
  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References
  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects
  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions
  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Zinc PCA
Zinc PCA

Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.

One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).

In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.

Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.

Physiological Effects
  • Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
  • Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
  • Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
  • Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
  • Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.

Role in Managing Dermatological Conditions
  • Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
  • Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
  • Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
  • Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.

References
  • Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
  • Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
  • Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
  • Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.
Retinoic acid analogue
Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects
  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits
  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Inflacin Serum: Trial Inflacin Serum: Trial Inflacin Serum: Trial Inflacin Serum: Trial
DermExcel™ | Inflacin Serum
Inflacin Serum: Trial Sale priceR 135.00
  • Acne: Target acne-causing bacteria and reduce inflammation, minimizing the occurrence of acne breakouts.
  • Blackheads: Dissolve and extract clogged pore content, effectively treating and preventing blackheads.
  • Oily Skin: Helps to regulate excess sebum production, improving skin appearance and reducing shininess.
  • Enlarged Pores: Minimize the appearance of enlarged pores by removing dead skin cells and regulating oil production.
  • Inflammation: Reduce inflammation associated with various skin conditions, including acne, rosacea, and premature aging.
  • Premature Aging: Combat visible signs of premature aging by promoting cell turnover and stimulating cell structures.
  • Combination Skin: Helps to balance oil production and maintain the skin's moisture balance in combination skin which experiences both oily and dry areas.
  • Skin Texture and Tone: Stimulates cellular turnover, leading to improved skin texture, firmness, and skin tone.
  • Rosacea-Prone or Red Skin: The anti-inflammatory, anti-bacterial, exfoliating, and sebum regulation properties of Inflacin serum soothe and relieve skin prone to rosacea or persistent redness.
  • Shaving Bumps and Ingrown Hair: Soothe shaving bumps and prevent ingrown hairs by exfoliating the skin and preventing pore clogging.

Active ingredients
  • Niacinamide
    • Niacinamide

    Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

    Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

    Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

    Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

    Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

    HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
    • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
    • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
    • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
    • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
    • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
    • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
    • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
    • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
    • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
    • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
    • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
    • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
    • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
    • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
  • Salicylic acid
    • Salicylic acid

    Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

    Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

    Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

    Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

    Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

    HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
    • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
    • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
    • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
    • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
    • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
    • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
    • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
    • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
    • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
    • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
    • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
    • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
    • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
    • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
  • Zinc PCA
    • Zinc PCA

    Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

    Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

    Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

    Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

    Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

    HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
    • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
    • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
    • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
    • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
    • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
    • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
    • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
    • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
    • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
    • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
    • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
    • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
    • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
    • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
  • Retinoic acid analogue
    • Retinoic acid analogue

    Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

    Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

    Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

    Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

    Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

    HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
    • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
    • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
    • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
    • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
    • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
    • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
    • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
    • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
    • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
    • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
    • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
    • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
    • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
    • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Full ingredient list

    Aqua, Polyethylene Glycol, Niacinamide, Salicylic acid, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Zinc PCA, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Sodium Phytate & Aqua & Alcohol, Butylene Glycol, Hydrolyzed Yeast Protein, Fomes Officinalis (Mushroom) Extract, Pyridoxine, Niacinamide, Panthenol, Allantoin, Threonine, Biotin, Tocopherol, Disodium EDTA

Morning & / or Evening
  • Application time: Apply in the morning and / or in the evening on cleansed skin.
  • Frequency: Every day or as per your Dermal Diagnosis regimen instructions.

1. Cleanse
  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply
  • Take a small amount of serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.

3. Wait
  • Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes 1-2 minutes.

Important notes
  • Clean skin: The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
  • Dry skin: Unlike Collagen and Retinol serums, the skin should be dry when applying Inflacin serum. This will allow for the optimal potency of the Salicylic acid in Inflacin serum.
  • Less is more: serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.

Inflacin serum

Mode of action

indications for Inflacin Serum: Trial

ingrown hair
blackheads
whiteheads
Clogged Pores
Enlarged Pores
Rough Skin Texture
Acne / Breakouts
Inflammation
Rosacea / Red Skin
Folliculitis
Pigmentation
Aging Skin
Sensitive Skin
DermExcel™ | Inflacin Serum: Trial

Medical-grade treatment for oily, acne-prone, and combination skin that reduces pimples, blackheads, and inflammation, unclogs pores, regulates sebum, and stimulates cell turnover.

inflacin serum

targets all phases of the acne process

increased sebum

clogged pores

bacterial infiltration

inflammation

salicylic acid

niacinamide

zinc pca

retinol

increased sebum

salicylic acid

niacinamide

zinc pca

retinol

clogged pores

salicylic acid

retinol

bacterial infiltration

salicylic acid

niacinamide

zinc pca

retinol

inflammation

salicylic acid

niacinamide

zinc pca

retinol

salicylic acid

pore clearing action

Sebum (oil) and dead skin cells accumulate inside the pores, causing blackheads and whiteheads.

Salicylic acid has the unique ability to penetrate the pores and to dissolve and extract the oil and dead skin cell plug.

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Inflacin Serum: Trial

mode of action on acne

REGULATE SEBUM (OIL) PRODUCTION AND EXCRETION

REGULATE SEBUM (OIL) PRODUCTION AND EXCRETION

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

  • The sebaceous glands' excretion of lipids (oil) is controlled hormonally.
  • Sebaceous glands are located all over the body but are most prominent in the face, back, chest, and shoulders. They become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
  • This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
  • Hormones continue to affect sebaceous gland activity into adulthood.

All the main active ingredients in Inflacin serum contribute to sebum regulation.

PREVENT DEAD SKIN CELLS AND OIL BUILD-UP IN THE PORES

PREVENT DEAD SKIN CELLS AND OIL BUILD-UP IN THE PORES

SALICYLIC ACID; RETINOL

  • The first stage of acne is called comedogenesis (formation of comedones / clogged pores): the exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone. 
  • This can be caused by factors such as a) increased sebum, b) inflammation of the hair follicle walls, which prevents the release of the exfoliated dead skin cells, and c) increased cohesion (stickiness) of dead skin cells.
  • Retinol reduces skin cells' positive and negative charges, making them less "sticky."
  • Salicylic acid dissolves and extracts dirt, oil, and cellular debris in the pores and follicles.

Retinol and Salicylic acid combination, unclog congested pores through their various mechanism of actions.

Prevent bacterial infiltration

Prevent bacterial infiltration

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

  • Bacteria invade the comedone (clogged pore).
  • Dead skin cells and sebum are excellent food sources for bacteria, creating an ideological environment for their growth.
  • The bacteria release inflammatory factors that lead to the next stage of acne.

All the main active ingredients contribute to the prevention and treatment of bacterial infiltration.

DOWN-REGULATE THE INFLAMMATORY RESPONSE

DOWN-REGULATE THE INFLAMMATORY RESPONSE

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

  • Inflammation continues with increased redness and pus - clinically detectable as papules or pustules.
  • Continued inflammation may cause the hair follicle to rupture and the bacteria and debris to be released into the dermis - when severe, this can lead to scarring.

All the main active ingredients contribute to down-regulating the inflammatory response.

Rosacea

Stages and treatment objectives

The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.

Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

Normal Skin

Normal Skin
  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.

Phase 1

Phase 1
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

Phase 2

Phase 2
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.

Phase 3

Phase 3
  • The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

zinc pca as rosacea and acne treatment

anti-inflammatory
anti-inflammatory

Inhibits mast cell degranulation and thereby reduces histamine secretion, an important mediator of inflammatory response.

anti-bacterial
anti-bacterial

The topical application of Zinc PCA hinders microbial growth. Its antiseptic properties limit the proliferation of acne-causing bacteria in the skin. 

sebum (oil) regulator
sebum (oil) regulator

It inhibits the activity of the 5 alpha-reductase enzymes to control excessive sebum production. 

testimonials

Customer Reviews

Based on 2589 reviews
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(93)
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(28)
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I
Isabel de Reuc
A new me!!

This is by far one of the most amazing product ever used by me for my specific need,wonderful in one word!!!!

C
Charlene Meyer

Love this product!

K
Katinka De Lange
Clear skin

Skin is more radiant and smoother. Will definitely recommend

S
Sonet Ueckermann
Collagen Serum

Love my Collagen serum!! I notice the difference immediately when I run out. My skin feels so much more cared for when using it and definitely glows. It feels moistured and taken care off. The texture is also noticeably different!

N
Nosipho Ndzimbomvu
Amazing Products

Best retinol serum ever created.

R
Retha Badenhorst
Collagen serum

Love love love! Cant go without it! Use it daily!

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