DermExcel™

Inflacin Serum: Trial

Name: Inflacin Serum: Trial
Brand: DermExcel™
SKU: DX-ARS05
Price: 135.00 ZAR
Availability: InStock

4.9 / 5.0 from 2639 reviews

R 135.00

SIZE: 5 mL

Unclog Pores

↓ Sebum

Anti-Acne

↓ inflammation

anti-aging

A medical-grade treatment with a potent blend of anti-inflammatory and acne-combating ingredients to address skin issues in oily, acne-prone, and combination skin types. The formulation prioritizes preserving skin hydration while eliminating skin concerns like pimples and blackheads.

The serum's composition includes salicylic acid, known for its proficiency in unclogging pores and reducing acne-related inflammation. Zinc PCA is critical in regulating sebum production and minimizing oily skin complications. Niacinamide shrinks enlarged pores and alleviates inflammation related to acne and rosacea. Lastly, retinol stimulates cell turnover, aids in the fight against premature aging, and enhances overall skin texture and tone.

As a holistic approach, Inflacin Serum reduces current skin issues and aims to prevent future skin complications, thus promoting a healthier skin condition.

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with peratosis Pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Zinc PCA

Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.

Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.

One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).

In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.

Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.

Physiological Effects

Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.

Role in Managing Dermatological Conditions

Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.

References

Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

USE DURING PREGNANCY

Inflacin Serum: Trial

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in Pretoria.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

Acne: Target acne-causing bacteria and reduce inflammation, minimizing the occurrence of acne breakouts.
Blackheads: Dissolve and extract clogged pore content, effectively treating and preventing blackheads.
Oily Skin: Helps to regulate excess sebum production, improving skin appearance and reducing shininess.
Enlarged Pores: Minimize the appearance of enlarged pores by removing dead skin cells and regulating oil production.
Inflammation: Reduce inflammation associated with various skin conditions, including acne, rosacea, and premature aging.
Premature Aging: Combat visible signs of premature aging by promoting cell turnover and stimulating cell structures.
Combination Skin: Helps to balance oil production and maintain the skin's moisture balance in combination skin which experiences both oily and dry areas.
Skin Texture and Tone: Stimulates cellular turnover, leading to improved skin texture, firmness, and skin tone.
Rosacea-Prone or Red Skin: The anti-inflammatory, anti-bacterial, exfoliating, and sebum regulation properties of Inflacin serum soothe and relieve skin prone to rosacea or persistent redness.
Shaving Bumps and Ingrown Hair: Soothe shaving bumps and prevent ingrown hairs by exfoliating the skin and preventing pore clogging.

Morning & / or Evening

Application time: Apply in the morning and / or in the evening on cleansed skin.
Frequency: Every day or as per your Dermal Diagnosis regimen instructions.

1. Cleanse

Start with clean and dry skin.
Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply

Take a small amount of serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.

3. Wait

Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes 1-2 minutes.

Important notes

Clean skin: The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
Dry skin: Unlike Collagen and Retinol serums, the skin should be dry when applying Inflacin serum. This will allow for the optimal potency of the Salicylic acid in Inflacin serum.
Less is more: serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.

Active ingredients

Niacinamide

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Salicylic acid

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Zinc PCA

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Retinoic acid analogue

Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.

Full ingredient list

Aqua, Polyethylene Glycol, Niacinamide, Salicylic acid, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Zinc PCA, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Sodium Phytate & Aqua & Alcohol, Butylene Glycol, Hydrolyzed Yeast Protein, Fomes Officinalis (Mushroom) Extract, Pyridoxine, Niacinamide, Panthenol, Allantoin, Threonine, Biotin, Tocopherol, Disodium EDTA

Inflacin Serum: Trial

R 135.00

Inflacin Serum: Trial

product benefits

Sebum Regulation

Implement effective sebum regulation strategies to minimize complications and refine the visual condition of oily skin.

Unblock clogged pores

Penetrate deeply into the pores to dissolve excess sebum and debris, thereby reducing pore blockage and minimizing the risk of acne formation and enlarged pores.

Anti-inflammatory

Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.

Exfoliate and renew skin cells

Promote cell turnover by accelerating the removal of dead skin cells and stimulating the regeneration of new cells, resulting in a smoother, more radiant complexion.

Anti-Microbial

Manage microbial activity by inhibiting the growth of pathogenic bacteria, balancing the skin's microbiome, and reducing the risk of infections and inflammation.

Reduce signs of aging

Enhance skin firmness and elasticity by promoting the renewal of skin cells and accelerating cell turnover, reducing visible signs of aging.

Inflacin serum

Mode of action

Anti-Aging

NIACINAMINDE

Stimulates collagen synthesis and increases skin elasticity.
Prevents collagen and elastin breakdown through antioxidant activity.
Protects against DNA damage and supports cellular energy, boosting DNA repair and other vital cellular processes.
Increases ceramide production, enhancing skin barrier strength and hydration.

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SALICYLIC ACID

Exfoliates by softening and dissolving keratin, which encourages natural cell turnover.
Reduces fine lines and wrinkles by shedding dead skin cells, promoting a brighter and more even complexion.

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ZINC PCA

Protects skin from UV-induced collagen degradation. Zinc PCA helps suppress UVA-induced activation of activator protein, which in turn reduces collagenase production—an enzyme responsible for collagen breakdown. This activity helps prevent photoaging and supports skin structure.

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RETINOL

Prevents collagen and elastin degradation by activating retinoic acid receptors that accelerate skin renewal.
Boosts collagen production, helping the skin appear more youthful by encouraging the replacement of old cells with fresh ones.
Reduces inflammation that can accelerate skin aging.

Microbial Control

NIACINAMINDE

Regulates sebum (oil) production, reducing bacterial growth and minimizing inflammation that can lead to breakouts.
Activates antimicrobial peptides in the skin, enhancing natural defenses and providing long-lasting protection against acne-causing bacteria.

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SALICYLIC ACID

Reduces C. acnes bacterial proliferation by inhibiting essential proteins for bacterial survival, including fibrinogen, fibronectin, and alpha-hemolysin.
Neutralizes C. acnes bacteria, helping to prevent inflammation and reduce acne formation.

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ZINC PCA

Limits the growth of acne-causing bacteria with antiseptic properties, reducing the potential for breakouts.
Controls excess sebum by inhibiting the 5 alpha-reductase enzyme, which helps prevent an environment that supports bacterial growth.
Demonstrates efficacy in targeting C. acnes bacteria, as shown in studies, supporting clear and balanced skin.

Acne Treatment

NIACINAMINDE

Reduces inflammation by inhibiting inflammatory messengers.
Decreases sebum production, which helps prevent bacterial growth and acne-related inflammation.

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SALICYLIC ACID

Minimizes inflammatory response by blocking key inflammatory messengers.
Penetrates into pores to dissolve excess sebum and cellular debris, effectively unclogging pores and reducing acne formation.
Helps maintain a balanced, acne-resistant environment by regulating sebum production.

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ZINC PCA

Balances sebum production by inhibiting the 5 alpha-reductase enzyme, reducing the likelihood of excess oil buildup.

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RETINOL

Enhances cellular communication, preventing pore clogging and excessive sebum.
Accelerates exfoliation, which unclogs pores and helps reduce acne risk.
Retinol will reduce inflammation that contributes to the formation of acne.

Exfoliation

SALICYLIC ACID

Salicylic acid acts as a keratolytic agent, dissolving keratin to break down dead skin cells within pores, allowing for deep exfoliation and helping to clear clogged pores.
By disrupting the intercellular bonds (desmosomes) that hold dead skin cells together, salicylic acid encourages natural shedding of the outer skin layer, resulting in a smoother, refined skin texture.

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RETINOL

Retinol accelerates cell turnover, promoting the shedding of surface cells to reveal fresher, healthier skin layers.
By supporting the natural desquamation process, retinol helps to unclog pores and maintain a clearer skin texture over time

Pigmentation Treatment

NIACINAMINDE

Prevents DNA damage through its antioxidant activity, reducing oxidative stress and protecting against pigment-related DNA damage. By neutralizing free radicals, niacinamide helps limit the triggers that can increase melanin production and lead to an uneven skin tone.
Inhibits melanosome transfer, meaning it reduces the movement of pigment-carrying vesicles (melanosomes) from melanocytes to the surrounding skin cells. This action helps prevent the spread of pigmentation and supports a more balanced skin tone.

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RETINOL

Reduces melanin synthesis by inhibiting tyrosinase, a crucial enzyme in melanin production, which helps to prevent new pigmentation from forming and is especially beneficial for managing hyperpigmentation.
Increases cell turnover and promotes the natural shedding of pigmented cells through its keratolytic effects, gradually fading areas of hyperpigmentation and revealing a brighter, more even complexion over time.

Regulate Sebum (oil)

NIACINAMINDE

Reduces overall sebum production by influencing sebaceous gland activity. Through this reduction in oil output, niacinamide helps prevent the overproduction of sebum.

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SALICYLIC ACID

Being oil-soluble, Salicylic acid can penetrate deeply into sebum-rich pores, where it helps to dissolve excess oils and impurities. This allows Salicylic acid to balance sebum levels within the pores, reducing surface shine and helping to prevent pore blockages that lead to breakouts.

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ZINC PCA

Controls excessive sebum production by inhibiting the activity of the 5 alpha-reductase enzyme, which is responsible for converting hormones into sebum. By regulating this enzyme, Zinc PCA helps prevent oil buildup that can clog pores and contribute to acne formation.

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RETINOL

Reduces sebum production by promoting skin cell turnover and influencing sebaceous gland activity, helping to manage oil levels on the skin’s surface. This decrease in sebum can support a clearer complexion by reducing the likelihood of clogged pores and associated breakouts.

Unclog Pores

SALICYLIC ACID

As a beta hydroxy acid (BHA), Salicylic acid is oil-soluble, allowing it to penetrate deeply into pores and dissolve the buildup of oil, dead skin cells, and debris. This makes it particularly effective at directly decongesting and unclogging pores, especially in oily and acne-prone skin.

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RETINOL

Retinol promotes cellular turnover, which accelerates the shedding of dead skin cells on the skin's surface and within pores. This helps prevent pore blockages from forming and gradually clears out existing congestion.

Anti-inflmmatory

NIACINAMINDE

Modulates inflammatory responses by inhibiting pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α), thereby reducing redness, swelling, and irritation. By promoting a balanced immune response, Niacinamide helps alleviate inflammation commonly associated with acne, rosacea, and other inflammatory skin conditions.
Regulates sebum production, minimizing the excess oil that can contribute to inflammation and acne formation by creating a less favorable environment for acne-causing bacteria.

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SALICYLIC ACID

Exerts anti-inflammatory effects through inhibition of the arachidonic acid pathway, which reduces the synthesis of pro-inflammatory prostaglandins and leukotrienes. This inhibition helps to alleviate redness, pain, and swelling at the cellular level, making Salicylic acid beneficial for inflammatory skin conditions such as acne, rosacea and seborrheic dermatitis.

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ZINC PCA

Provides targeted anti-inflammatory effects by suppressing inflammatory mediators involved in skin irritation, including cytokines and enzymes that drive inflammation. This action helps to calm conditions such as acne, eczema, and rosacea, providing relief to sensitive and reactive skin types while maintaining skin barrier integrity.

indications for Inflacin Serum: Trial

ingrown hair
blackheads
whiteheads
Clogged Pores
Enlarged Pores
Rough Skin Texture
Acne / Breakouts
Inflammation
Rosacea / Red Skin
Folliculitis
Pigmentation
Aging Skin
Sensitive Skin

Medical-grade treatment for oily, acne-prone, and combination skin that reduces pimples, blackheads, and inflammation, unclogs pores, regulates sebum, and stimulates cell turnover.

inflacin serum

targets all phases of the acne process

increased sebum

clogged pores

bacterial infiltration

inflammation

salicylic acid

niacinamide

zinc pca

retinol

increased sebum

salicylic acid

niacinamide

zinc pca

retinol

clogged pores

salicylic acid

retinol

bacterial infiltration

salicylic acid

niacinamide

zinc pca

retinol

inflammation

salicylic acid

niacinamide

zinc pca

retinol

salicylic acid

pore clearing action

Sebum (oil) and dead skin cells accumulate inside the pores, causing blackheads and whiteheads.

Salicylic acid has the unique ability to penetrate the pores and to dissolve and extract the oil and dead skin cell plug.

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Inflacin Serum: Trial

mode of action on acne

REGULATE SEBUM (OIL) PRODUCTION AND EXCRETION

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

The sebaceous glands' excretion of lipids (oil) is controlled hormonally.
Sebaceous glands are located all over the body but are most prominent in the face, back, chest, and shoulders. They become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
Hormones continue to affect sebaceous gland activity into adulthood.

All the main active ingredients in Inflacin serum contribute to sebum regulation.

PREVENT DEAD SKIN CELLS AND OIL BUILD-UP IN THE PORES

SALICYLIC ACID; RETINOL

The first stage of acne is called comedogenesis (formation of comedones / clogged pores): the exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
This can be caused by factors such as a) increased sebum, b) inflammation of the hair follicle walls, which prevents the release of the exfoliated dead skin cells, and c) increased cohesion (stickiness) of dead skin cells.
Retinol reduces skin cells' positive and negative charges, making them less "sticky."
Salicylic acid dissolves and extracts dirt, oil, and cellular debris in the pores and follicles.

Retinol and Salicylic acid combination, unclog congested pores through their various mechanism of actions.

Prevent bacterial infiltration

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

Bacteria invade the comedone (clogged pore).
Dead skin cells and sebum are excellent food sources for bacteria, creating an ideological environment for their growth.
The bacteria release inflammatory factors that lead to the next stage of acne.

All the main active ingredients contribute to the prevention and treatment of bacterial infiltration.

DOWN-REGULATE THE INFLAMMATORY RESPONSE

SALICYLIC ACID; NIACINAMIDE; ZINC PCA; RETINOL

Inflammation continues with increased redness and pus - clinically detectable as papules or pustules.
Continued inflammation may cause the hair follicle to rupture and the bacteria and debris to be released into the dermis - when severe, this can lead to scarring.

All the main active ingredients contribute to down-regulating the inflammatory response.

Rosacea

Stages and treatment objectives

The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.

Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

Normal Skin

Healthy skin with a perfect balance between normal microflora and skin receptors.
Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
These receptors should not trigger an immune response by binding to normal microflora.

Phase 1

PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

Phase 2

Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.

Phase 3

The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

Active ingredients

Acne Treatment with Salicylic acid

Keratolytic

Disrupts cellular junctions to exfoliate dead skin, revealing bright, new cells.

Comedolytic

Unclog pores by dissolving and extracting dirt, oil, and cellular debris.

anti-inflammatory

Inhibit the inflammation that leads to breakouts, redness, and skin damage.

Anti-bacterial

Inhibits bacteria responsible for causing and aggravating acne and rosacea.

zinc pca as rosacea and acne treatment

anti-bacterial

The topical application of Zinc PCA hinders microbial growth. Its antiseptic properties limit the proliferation of acne-causing bacteria in the skin.

sebum (oil) regulator

It inhibits the activity of the 5 alpha-reductase enzymes to control excessive sebum production.

anti-inflammatory

Inhibits mast cell degranulation and thereby reduces histamine secretion, an important mediator of inflammatory response.

testimonials

Best product I ever used

Inflacin Serum

I have seen a noticable improvement in my skin and the texture of my skin. Wil continue to use this amazing product!

Happy

Baie goeie produkte. A little goes a long way

Retinol Serum

It’s my best

Hands down thee best product for my skin, few flare ups and this product controls it

I never thought I could love a product so much!

I’ve fallen in love with skincare all over again. Could visibly see improvement with my skin within the first week. I feel comfortable enough to go out in public with no make up.

1 2 3

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Inflacin Serum: Trial