Dermaplan™

Firsthand™ treatment

Name: Firsthand™ treatment
Brand: Dermaplan™
SKU: DP-FHAND50
Price: 272.17 ZAR
Availability: InStock

4.8 / 5.0 from 17 reviews

R 272.17

SIZE: 50 mL

Dry skin

Rough texture

Inflammation

Eczema

Ichthyosis

Rejuvenize, brighten and soothe dehydrated hands.

Firsthand™ stands as an advanced Physiological Ceramide-Dominant Barrier-Repair Therapy, constructed with a robust spectrum of moisturizing agents, constituting an intelligent moisturizing complex. The potency of this hand emulsion is amplified by its multifunctional formulation designed to promote collagen synthesis, attenuate the impact of solar damage, inhibit the reduction of skin elasticity, and mend a compromised skin barrier.

Key components such as Ceramides, Cholesterol, and Fatty acids work synergistically to reinforce the integrity of the skin's lipid barrier, bolstering its resilience against external insults. Incorporating Niacinamide invigorates cellular energy and ameliorates skin tone and texture, while d-panthenol, a potent vitamin B5 derivative, provides potent anti-inflammatory effects and aids in skin repair. Moreover, adding hyaluronic acid ensures optimum hydration by attracting and retaining moisture, which is vital for maintaining the skin's suppleness and health.

After utilizing Firsthand™, hands manifest signs of rejuvenation and radiance, while desiccation is thoroughly alleviated. The physiological enhancements rendered by Firsthand™ result in hands that appear and feel younger and stronger and exhibit enhanced health.

Emollients

Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

d-Panthenol

d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.

d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:

Physiological Effects

Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.

Role in Managing Dermatological Conditions

Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.

References

Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Medilan™

Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.

Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.

Physiological Effects

Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.

Role in Managing Dermatological Conditions

Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.

References

Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.

Ceramides

Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.

Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.

The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.

Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.

Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.

Physiological Effects

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Role in Managing Dermatological Conditions

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

References

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

USE DURING PREGNANCY

Firsthand™ treatmentis safe to use during pregnancy.

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in Pretoria.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

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Our Secure Payment Promise backs every transaction with DermExcel. We partner with trusted payment providers to create the best shopping experience for you.

Simple. Effective. Ethical. That's not just our skincare philosophy but our approach to your security too.

Firsthand™ treatment

R 272.17

Aging hands: The inclusion of collagen-stimulating ingredients such as Niacinamide helps reduce the visible signs of aging, such as fine lines, wrinkles, and sun damage, making Firsthand beneficial for aging hands.
Dry Skin (Xerosis): Provides intense hydration to address the symptoms of dry skin, such as tightness, roughness, and flakiness.
Loss of elasticity: By promoting collagen synthesis and improving hydration, Firsthand helps enhance the elasticity and firmness of the hands, making it a suitable option for addressing loss of elasticity.
Sun-damaged hands: The collagen-boosting properties of Firsthand, coupled with its moisturizing agents, contribute to the reduction of sun-induced skin damage, promoting a more youthful and even skin tone.
Ichthyosis: Effective in addressing the scaling, roughness, and excessive dryness associated with ichthyosis, a genetic disorder that impairs the skin's ability to retain moisture.
Impaired barrier function: Firsthand's Physiological Ceramide-Dominant Barrier-Repair Therapy aids in repairing and strengthening the skin's natural barrier, which may be compromised due to environmental factors, harsh products, or excessive dryness.
Rough and textured hands: The combination of moisturizing agents, ceramides, and fatty acids in Firsthand works to improve the texture of the skin, providing a smoother and softer feel.
General hand care: Firsthand can be used as a part of a regular hand care routine to maintain optimal hydration, protect the skin barrier, and promote overall hand health.

Active ingredients

Emollients

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

d-Panthenol

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Niacinamide

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Medilan™

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Ceramides

Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.

Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.

Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.

Full ingredient list

Aqua, white soft paraffin, extra pure lanolin, emulsifying wax, glycerin, stearic acid, ceramides, cholesterol, liquid paraffin, niacinamide, cetyl alcohol, cetomacrogol, isostearyl isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, ethyl hexyl glycerin, phenoxyethanol, carbomer, d-panthenol, sodium hyaluronate, C12-17 alkane, triethanolamine.

Apply Firsthand as often as required on clean hands.

Firsthand™ treatment

product benefits

Soothes Irritated Skin

Soothes and calms irritated skin by reducing inflammation and providing immediate relief, helping to restore comfort and balance to distressed skin.

Barrier Repair

Physiological barrier repair by strengthening the skin's structural integrity, reducing sensitivity and increasing the skin's ability to defend against harmful agents

Intense hydration

Shield the skin from external irritants and pollutants by forming a protective barrier, providing continuous hydration, improving skin elasticity, and supporting the skin's natural defense mechanisms.

Control moisture balance

Reduces transepidermal water loss by reinforcing the skin's natural barrier, ensuring long-lasting hydration and protection against dryness.

mediment

mode of action

Emmolients

Main Benefits of Emollients

Hydration: Emollients fill in the gaps between skin cells that are missing moisture, effectively hydrating the skin. Replenishing lost water content helps to maintain the skin's natural moisture balance, making the skin feel softer and smoother.
Barrier Protection: They form a protective layer over the skin surface, which helps to prevent transepidermal water loss (TEWL), a common issue in dry and eczema-prone skin. This protective layer shields the skin from environmental irritants and allergens, reducing the risk of flare-ups and infections.
Skin Repair: Emollients help to repair the skin barrier function, which is often compromised in conditions like eczema, psoriasis, and dermatitis. By restoring the integrity of the skin barrier, emollients can improve the skin's resilience against irritants and reduce symptoms of itchiness and inflammation.
Flexibility and Elasticity: By keeping the skin moist, emollients increase its flexibility and elasticity, which can help to prevent cracks and fissures in dry or thickened skin areas. This is particularly beneficial in preventing the skin from becoming brittle and breaking, especially in areas prone to eczema or psoriasis.
Soothing Effect: Emollients have a soothing effect on the skin, relieving itching and discomfort associated with dryness and skin conditions. This can help to reduce scratching, which in turn prevents further skin damage and potential infections.
Enhanced Skin Appearance: Regular use of emollients can improve the appearance of the skin, making it look healthier and more vibrant. They can help to diminish the appearance of dry or flaky skin, providing a smoother and more even skin texture.

Emollients are beneficial for maintaining and restoring skin health, offering hydration, protection, and relief from various skin conditions. Their regular application is key in managing dry skin, enhancing skin barrier function, and improving overall skin appearance and comfort.

d-Panthenol

D-Panthenol stimulates the proliferation of dermal fibroblasts and can accelerate cell turnover.

WOUND HEALING

D-Panthenol is used in medical wound-healing formulations to help treat skin injuries, burns, and sunburn.
It's also beneficial after medical and cosmetic surgeries for its wound-healing properties.
It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.

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REPAIR SKIN BARRIER FUNCTION

D-Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
D-Panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration.

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ANTI-INFLAMMATORY

Panthenol’s moisturizing properties also contribute to its anti-inflammatory nature.
Keeping the skin moisturized can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
Studies indicate that D-Panthenol may alleviate facial redness from winter xerosis in people with sensitive skin.

Niacinamide

INHIBIT HYPERPIGMENTATION

Prevents DNA damage through antioxidant activity.
Prevent melanosome transfer from melanocytes to surrounding skin cells.

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TREATING ROSACEA, ACNE AND OTHER INFLAMMATORY SKIN CONDITIONS

Reduce the inflammatory response by inhibiting inflammatory messengers.
Provides long-lasting protection against bacteria through activation of anti-microbial peptides
Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.

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TREATING AND PREVENTING PREMATURE SKIN AGING

Stimulate collagen synthesis and significantly increase skin elasticity.
Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
Prevents DNA damage through antioxidant activity.
Increases production of ceramides and other stratum corneum lipids to improve skin barrier function.
Niacinamide boosts cellular energy and may enhance energy-dependent cellular processes such as DNA repair.

Medilan™

KEY BENEFITS

Medilan imitates many functions of human skin lipids, which is nearly twice as effective as the physiological lipids in human skin.

Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.

In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment.

Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.

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REPLENISHING ESSENTIAL LIPIDS

Medilan™ supplements the skin with the lipids essential to skin health.

Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.

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REPAIRING THE SKIN’S NATURAL BARRIER

Medilan™ effectively accelerates the repair of the skin’s natural barrier function.

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PROTECTING AGAINST MICROBIAL INFECTION

Medilan is proven to control a variety of microorganisms.

Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.

Ceramides

Ceramides play a crucial role in maintaining the skin's barrier function and overall health at the physiological level. Their mode of action involves several vital mechanisms:

Structural Role in Skin Barrier: The skin barrier, primarily located in the stratum corneum (the outermost layer of the skin), consists of corneocytes (dead skin cells) embedded in a lipid matrix. This matrix comprises ceramides, cholesterol, and free fatty acids in a specific ratio. Ceramides are the largest component and are essential for the barrier's structural integrity, functioning like the 'mortar' that holds the 'bricks' (corneocytes) together. By maintaining this structure, ceramides prevent excessive water loss and protect against the entry of harmful substances.
Hydration and Water Retention: Ceramides help the skin retain moisture by forming a protective layer that limits water evaporation. This is crucial for keeping the skin hydrated, plump, and resilient.
Regeneration and Repair: Ceramides can support the skin's natural repair processes, particularly after damage caused by environmental factors like UV radiation, pollution, and irritants. They help restore the barrier function, promoting healing and reducing the risk of skin conditions such as dermatitis and eczema.
Anti-inflammatory Properties: Some studies suggest that ceramides may possess anti-inflammatory properties. These properties help soothe irritated skin and reduce inflammation, beneficial in conditions like psoriasis and eczema.
Signaling Molecules: Beyond their structural role, ceramides also function as signaling molecules that can influence cell proliferation, differentiation, and apoptosis (programmed cell death). This is significant for skin homeostasis and maintaining a healthy skin barrier.

References:

Pilgram, G.S.K., Vissers, D.C.J., van der Meulen, H., Pavel, S., Lavrijsen, S.P.M., Bouwstra, J.A., Koerten, H.K. (2001). The effect of 2-hydroxyoctadecanoic acid on human skin and its role in dry skin conditions. Archives of Dermatological Research, 293(4), 191-197.
Elias, P.M., Wakefield, J.S. (2014). Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Clinical Reviews in Allergy & Immunology, 41(3), 282-295.
Uchida, Y. (2014). Ceramide signaling in mammalian epidermis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1841(3), 453-462.

These references highlight the critical role of ceramides in skin physiology, underpinning their use in dermatological products like Curexema for treating and managing dry skin conditions.

Hyaluronic acid

Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body, including wound repair, cell migration, and cell signalling.
With age, hyaluronic acid in the skin decreases sharply, resulting in a loss of hydration, volume and plumpness. Lines and wrinkles also appear, leaving skin looking dull and lacklustre.
Hyaluronic acid comes in various molecular sizes. Larger molecules stay on the surface and give the skin a ‘dewy’ look, while smaller molecules penetrate deeper into the skin to deliver their hydration and plumping benefits.
The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
High molecular weight: Doesn't penetrate the epidermis.
Very low molecular weight: Penetrate the skin efficiently but can induce a pro-inflammatory response.
Low molecular weight HA [50 kDa]: Penetrates into the skin well and does not cause inflammation.

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HYDRATION

Hyaluronic acid can bind water up to 1000 times its volume and contributes to cellular growth, adhesion, and membrane receptor function.
Hyaluronic acid reinforces the intercellular structures and produces the elastoviscous fluid matrix that firmly envelops collagen and elastin fibres.
Hyaluronic acid holds moisture and provides firmness and radiance to the skin.

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ANTI-AGING

Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes.
Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity.