DermExcel™

Medi-Zinc Cleanser: Trial

Name: Medi-Zinc Cleanser: Trial
Brand: DermExcel™
SKU: DX-ZINC10
Price: 77.00 ZAR
Availability: InStock

4.9 / 5.0 from 816 reviews

R 77.00

SIZE: 10 mL

Itch Relief

Anti-Acne

↓ inflammation

anti-redness

Anti-microbial

A powerful hypoallergenic medicated solution with beneficial properties attributed to its active constituent, Zinc Pyrithione. This chemical compound, FDA-approved and clinically recognized, delivers strong antibacterial and antifungal action, making the cleanser an ideal choice for managing skin conditions associated with redness, flaking, irritation, and itching.

Zinc Pyrithione's efficacy, compounded by a gentle cleansing base, facilitates the lifting and removing of impurities, leaving the complexion refreshed. Concurrently, it sustains a tranquil skin environment, reducing inflammation and discomfort. As a daily cleansing aid, Medi-Zinc Cleanser proposes a reliable, scientifically-backed intervention in fostering skin health and comfort.

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological Effects

Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Role in Managing Dermatological Conditions

Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.

Free Gift with Medi-Zinc Cleanser: Trial:

Microfibre Sponge

Free with 175ml Cleanser

USE DURING PREGNANCY

Medi-Zinc Cleanser: Trial is safe to use during pregnancy.

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in Pretoria.
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When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
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RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

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Medi-Zinc Cleanser: Trial

R 77.00

Rosacea: The anti-inflammatory and antibacterial properties of Zinc Pyrithione help manage and alleviate the symptoms of rosacea.
Acne: The antibacterial properties of Zinc Pyrithione in Medi-Zinc Cleanser make it effective in managing acne by reducing bacteria on the skin's surface and controlling inflammation.
Seborrheic Dermatitis: This condition, which causes flaky, itchy, red skin, can be managed with the antifungal and anti-inflammatory properties of Zinc Pyrithione.
Redness: control and reduce redness associated with skin conditions like rosacea, dermatitis, and eczema.
Irritation: It is indicated for soothing skin irritation caused by various factors, including environmental aggressors, allergies, or sensitivities.
Itching: Medi-Zinc Cleanser provides relief from itching in itchy skin conditions such as contact dermatitis, insect bites, or allergic reactions.
Sensitive skin: Its hypoallergenic formulation makes it suitable for individuals with sensitive skin, providing a gentle and non-irritating cleansing option.
Psoriasis: The anti-inflammatory properties of Zinc Pyrithione can help manage the redness and irritation associated with psoriasis.
Eczema: While not a cure, the cleanser may help soothe the itching and inflammation associated with eczema.

Active ingredients

Zinc Pyrithione

Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.

Full ingredient list

Aqua, Polyethylene Glycol, Coco-Glucoside, Cocoamidopropyl Betaine, Sodium Lauroyl Sarcosinate, Zinc Pyrithione, Phenoxyethanol & Ethyl hexyl Glycerin, Acrylates Copolymer, Triethanolamine, Coco-Glucoside & Glyceryl Oleate

Morning & Evening

Application time: Use in the morning and evening.
Frequency: Every day or as per your Dermal Diagnosis regimen instructions.

1. Wet your fingers

Slightly wet your fingers for easier application. Do not wet your face before applying Medi-Zinc; this will cause the product to run into your eyes and sting.
Lather the areas you want to treat and make sure the product has good contact with the skin.

2. Treatment time

Keep the product in contact with your skin for at least 5 minutes, most preferably 10 minutes.
This will allow the product to penetrate the follicles optimally and ensure the active ingredient is effective.

Tip: Keep the cleanser on your skin while brushing your teeth, bathing, or getting dressed.

3. Rinse

Use a clean, wet, lukewarm face cloth or microfiber face sponge. This method provides better control, preventing the product from running into your eyes. Additionally, it effectively removes excess makeup and loose, peeling skin.

Important notes

Repeat the application nightly for at least 3-4 weeks.
Because yeast, fungi, and bacteria do not develop resistance toward Zinc Pyrithione, you can continue to use Medi-Zinc cleanser regularly even after symptoms have cleared. Consistent application of Zinc Pyrithione will result in continuous antimicrobial activity.
Do not stop your treatment after all the signs and symptoms have cleared up. Problem areas should be in contact with Zinc Pyrithione at least once per week.
To keep the Malassezia yeast from returning, ensure enough Zinc Pyrithione is in contact with the skin around the problem areas.
Always remember the 5-10 minute skin contact rule.

medi-zinc cleanser

mode of action

Anti-inflammatory

Inflammation on the skin contributes to itchiness, redness, and irritation, which are common symptoms of various skin conditions. Zinc Pyrithione reduces inflammation, which helps to alleviate these symptoms.
Zinc Pyrithione positively affects the immune system by balancing pro-inflammatory and anti-inflammatory cytokines in the body. Studies published in the Journal of Dermatological Science indicate that Zinc Pyrithione increases the production of anti-inflammatory cytokines in human skin cells. These cytokines are involved in the immune response, important for regulating inflammation, and promoting healing.
Studies further indicate that Zinc Pyrithione significantly reduces the production of pro-inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha. This action boosts the body’s natural defenses against yeast and reduces the severity of skin irritation.
Cytokine production is a complex process involving a balance between pro-inflammatory and anti-inflammatory cytokines. Zinc Pyrithione supports a healthy balance between inflammation and immune function, helping to manage skin sensitivity and irritation.
Zinc Pyrithione also has direct anti-inflammatory effects on the skin by reducing the production of certain enzymes that contribute to inflammation.

Anti-fungal

Zinc Pyrithione has broad-spectrum antimicrobial activity, inhibiting and reducing the burden of Malassezia yeast on the skin. It targets gram-positive and gram-negative bacteria, as well as other fungi that cause common fungal infections like ringworm, athlete's foot, and jock itch.
Zinc Pyrithione disrupts iron distribution across the yeast cell wall, effectively starving the yeast by interfering with essential respiratory functions.
Zinc Pyrithione disrupts the yeast’s cell membrane, preventing it from proliferating and reproducing. It binds to the yeast’s cell membrane, causing structural damage that ultimately leads to cell death.
Zinc Pyrithione also interferes with the metabolic processes of the yeast, disrupting the uptake of essential nutrients and altering the skin’s pH balance, making it more challenging for the yeast to survive and grow.
Zinc Pyrithione has a unique slow-release ability, persisting in the top layer of skin even after rinsing. This property imparts long-lasting control and sustained release of anti-yeast coverage, effectively suppressing Malassezia yeast overgrowth.
Yeast, fungi, and bacteria do not develop resistance to Zinc Pyrithione, allowing consistent application to provide continuous antimicrobial activity.

indications for Medi-Zinc Cleanser: Trial

Seborrheic Dermatitis
Facial and Body Acne
Rosacea / Red Skin
Inflammation
Clogged Pores
Folliculitis

Controls redness, flaking, and irritation, delivering antibacterial and antifungal action for healthy, comfortable skin.

the efficacy of zinc pyrithione

condition

action

evidence

atopic dermatitis and eczema

ZnPT formulated in body treatment is adjunctive to corticosteroid use for managing atopic dermatitis and eczema.
ZnPT alters skin levels of Malassezia yeast or Staphylococcus aureus bacteria, which is important in aggravating atopic dermatitis.
Malessezia yeast and its metabolites cause barrier aggravation in atopic dermatitis and eczema.
Approximately half of the differentially expressed stratum corneum proteins from dandruff and atopic dermatitis are the same, suggesting a common etiology.

A randomized controlled trial in children showed the benefits of ZnPT with lipids on skin microbiome diversity and atopic dermatitis score (SCORAD) when used in conjunction with 0.1% w/v hydrocortisone butyrate cream.

skin antisepsis

ZnPT in antiseptic products has a significant clinical impact, such as reducing surgical site infections through extended anti-microbial persistence.

In an expanded flora test on the forearm, ZnPT exhibits gradual activity against a broad spectrum of gram-negative and gram-positive bacteria and RNA and DNA viruses for up to three days.
Concentrations up to 0.25% ZnPT with alcohol were superior to other combination agents (e.g., iodine, chlorhexidine gluconate, and triclosan) for the persistence of antimicrobial effects.

uvb induced hyperplasia

ZnPT treatment prevents UVB-induced photoaging and skin cancer development, potentially as an additive to sunscreens. Further work is needed to demonstrate human efficacy and establish therapeutic doses.

1% ZnPT scalp treatment prevented skin thickening in study subjects exposed to UVB radiation and normalized levels of hypoxia-inducible factor-1α, influencing the cell cycle.

condition

atopic dermatitis and eczema

action

ZnPT formulated in body treatment is adjunctive to corticosteroid use for managing atopic dermatitis and eczema.
ZnPT alters skin levels of Malassezia yeast or Staphylococcus aureus bacteria, which is important in aggravating atopic dermatitis.
Malessezia yeast and its metabolites cause barrier aggravation in atopic dermatitis and eczema.
Approximately half of the differentially expressed stratum corneum proteins from dandruff and atopic dermatitis are the same, suggesting a common etiology.

evidence

condition

skin antisepsis

action

ZnPT in antiseptic products has a significant clinical impact, such as reducing surgical site infections through extended anti-microbial persistence.

evidence

In an expanded flora test on the forearm, ZnPT exhibits gradual activity against a broad spectrum of gram-negative and gram-positive bacteria and RNA and DNA viruses for up to three days.
Concentrations up to 0.25% ZnPT with alcohol were superior to other combination agents (e.g., iodine, chlorhexidine gluconate, and triclosan) for the persistence of antimicrobial effects.

condition

uvb induced hyperplasia

action

evidence

1% ZnPT scalp treatment prevented skin thickening in study subjects exposed to UVB radiation and normalized levels of hypoxia-inducible factor-1α, influencing the cell cycle.

Targets Malassezia Yeast: Zinc Pyrithione is particularly effective against Malassezia yeast, a fungus commonly found on the skin and scalp. This yeast can proliferate excessively, leading to dandruff and seborrheic dermatitis.

Disrupts Fungal Cell Membranes: Zinc Pyrithione works by disrupting the fungus's cell membranes, inhibiting its growth and survival. This action reduces the fungal population on the skin, alleviating symptoms associated with overgrowth.

Broad-Spectrum Activity: Zinc Pyrithione also possesses antibacterial properties that are effective against various bacteria that can contribute to skin irritation and infection. Reducing bacterial load helps prevent secondary infections and promotes skin healing.

Inhibits Bacterial Enzyme Systems: It interferes with enzyme systems within bacterial cells, leading to their death. This mechanism helps maintain skin flora balance and prevents conditions like acne and folliculitis.

testimonials

Pore Control

Excellent Product!

Renewal Facial Cleanser

Best cleanser that I ever used. It is soft on the face, cleans very well and no irritation on my face. All the Dermalhealth product are top of the range. Can recommend it with a smile. Product worth the price you pay