Dermaplan™

Cremedify

4.7 / 5.0 from 18 reviews

R 440.00

Pay interest-free installments from R 110.00 with various payment gateways selected at checkout.

Size:

Variant

Allergies

irritated skin

Inflammation

Ichthyosis

Eczema

An Emollient-Rich and Lipid-Replenishing Body Cream Cleanser for Ichthyosis, Eczema, Psoriasis, and Other Dry Skin Conditions.

Cremedify is a non-foaming moisturizing cleanser formulated to effectively soothe, nourish, and calm dry, itching, psoriasis, atopic dermatitis, and eczema-prone skin.

Cremedify contains Intelligent Lipid Bilayer technology that forms a double structural layer on the skin's surface to regulate water loss, strengthen and regenerate the skin's natural barrier and ensure long-lasting hydration.

Cremedify includes essential fatty acids to support the epidermal barrier and effectively clean sensitive and dry skin while improving overall skin health.

Take control of your skin's well-being with Cremedify, and embrace the transformative power of our scientifically-backed, ultra-gentle moisturizing cleanser.

Emollients

Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.

Physiological Effects

Hydration of Stratum Corneum: Emollients increase moisture content in the stratum corneum, the outermost layer of the skin, by reducing transepidermal water loss (TEWL). This is achieved through occlusion, which traps water in the skin.
Restoration of Skin Barrier Function: They aid in replenishing the skin's lipid barrier, which is essential for maintaining skin integrity and protective function.
Soothing and Smoothing Effects: Emollients smooth, flaky skin cells, making the skin surface appear smoother. They also provide a soothing effect, which can reduce itching and discomfort.
Anti-inflammatory Properties: Some emollients have ingredients that offer mild anti-inflammatory benefits, helping to reduce redness and irritation.

Role in Managing Dermatological Conditions

Atopic Dermatitis (Eczema): Emollients are a cornerstone in the management of eczema, helping to maintain skin hydration, reduce flare-ups, and minimize the need for topical corticosteroids.
Psoriasis: Regular use of emollients can reduce scaling and dryness associated with psoriasis, improving the efficacy of other topical treatments.
Ichthyosis and Xerosis: These conditions, characterized by dry, scaly skin, benefit significantly from emollients, which help hydrate and soften the skin.
Aging Skin: Emollients improve the appearance of aging skin by hydrating and reducing the visibility of fine lines and wrinkles.
Skin Protection: Emollients can protect the skin from irritation and breakdown in individuals with incontinence or those who are bedridden.

References

Proksch, E., & Lachapelle, J. M. (2005). The Management of Dry Skin with Topical Emollients. American Journal of Clinical Dermatology.
Lynde, C. W. (2001). Moisturizers: What They Are and a Practical Approach to Product Selection. Skin Therapy Letter.
Lodén, M. (2003). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.

Humectants

Humectants are a vital component in skincare, particularly for conditions characterized by impaired skin barrier function and excessive dryness. Their ability to attract and retain moisture in the skin makes them invaluable in both therapeutic and preventive dermatology.

Physiological Effects

Moisture Attraction: Humectants draw moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), enhancing skin hydration.
Enhancing Skin Barrier Function: By improving skin hydration, humectants help to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Skin Elasticity and Appearance: Improved hydration can enhance skin elasticity and reduce the appearance of fine lines and wrinkles, giving the skin a plumper and smoother look.
Soothing Effect: Humectants can have a soothing effect on the skin, particularly in conditions involving dryness or irritation.

Role in Managing Dermatological Conditions

Dry Skin (Xerosis): Humectants are key ingredients in many moisturizers and are highly effective in managing dry skin by providing and maintaining hydration.
Eczema and Dermatitis: Their moisturizing and soothing properties help in relieving symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Aging Skin: Humectants are used in anti-aging skincare products due to their ability to hydrate the skin and improve its appearance.
Psoriasis: They can aid in reducing the dryness and scaling associated with psoriasis.
Acne-Prone Skin: Certain humectants can be beneficial in acne treatments, as they provide necessary hydration without clogging pores.

References

Lodén, M. (2005). Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology.
Rawlings, A. V., & Canestrari, D. A. (2011). Moisturizer technology versus clinical performance. Dermatologic Therapy.
Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.

Glycerin

Glycerin, also known as glycerol, is a simple polyol compound widely used in dermatology due to its excellent moisturizing properties.

Glycerin's excellent hydrating properties, combined with its ability to soothe and improve skin barrier function, make it a highly valued ingredient in treating and managing various dermatological conditions, particularly those involving dryness and compromised skin barrier.

Physiological Effects

Hydration: Glycerin is a humectant that attracts water to the skin. It draws moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), improving hydration.
Skin Barrier Function: By enhancing skin hydration, glycerin helps to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
Soothing Effect: Its soothing effect on the skin can reduce irritation and discomfort in various skin conditions.
Elasticity and Resilience: Glycerin can improve skin elasticity and resilience, making the skin appear healthier and more supple.
Wound Healing: Some studies suggest that glycerin may accelerate wound healing processes and improve skin repair.

Role in Managing Dermatological Conditions

Dry Skin Conditions (Xerosis): Glycerin is a key ingredient in many moisturizers and is highly effective in managing dry skin by providing deep hydration.
Eczema and Dermatitis: Its moisturizing and soothing properties help relieve the symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
Psoriasis: Glycerin can aid in reducing the dryness and scaling associated with psoriasis.
Aging Skin: It is beneficial in anti-aging products because it hydrates the skin and improves its elasticity.
Wound Care: Glycerin-based products may be used to treat minor wounds and burns due to their potential role in enhancing wound healing.

References

Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
Harding, C. R. (2004). The stratum corneum: structure and function in health and disease. Dermatologic Therapy.
Lodén, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology.

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Role in Managing Dermatological Conditions

Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
Aging Skin: Niacinamide targets wrinkles and loss of firmness.
Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.

Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

In the realm of dermatological science, essential fatty acids (EFAs) have emerged as unsung heroes, offering a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin.

Pharmacological Advantages

EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.

Physiological Harmony

EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.

Biochemical Brilliance

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

References

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

USE DURING PREGNANCY

Cremedify

SHIPPING

Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
Where We Ship From: Orders are dispatched from our facilities in Pretoria.
Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.

For any shipping inquiries, our customer service team is ready to assist.

RETURNS

Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

SECURE PAYMENT

If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.

Feel as confident in us as we want you to feel in your skin.

Dry and dehydrated skin: Soothe, nourish, and calm dry skin by providing long-lasting hydration and supporting the skin's natural barrier.
Compromised skin barrier: Intelligent Lipid Bilayer technology helps to regulate water loss and strengthen and regenerate the skin's natural barrier.
Ichthyosis / Itching: The moisturizing and calming ingredients in Cremedify help alleviate itching associated with dry skin.
Psoriasis: Aids in managing psoriasis by moisturizing the skin, reducing redness, and supporting the skin's natural barrier function.
Sensitive skin: Gentle formulation suitable for individuals with sensitive skin, providing effective cleansing without irritation.
Atopic dermatitis / Eczema: Reinforce the skin's natural barrier and address the symptoms of eczema, including dryness, itching, and inflammation.

Morning & Evening

Application time: Use in the morning and evening.
Frequency: Every day or as per your Dermal Diagnosis regimen instructions.

1. Dampen or wet the skin

Ensure your skin is damp. Using Cremedify during a shower or bath is best for full-body cleansing.

2. Apply

Gently massage the cleanser into your skin in circular motions, focusing on areas with dryness, itching, psoriasis, atopic dermatitis, or eczema.

3. Rinse

Rinse off with lukewarm water. Avoid using hot water as it can dry out the skin further.

4. Pat Dry

Gently pat your skin dry with a soft towel, leaving it damp. Do not rub, as this can irritate the skin.

Note

For optimal results, follow up with Dermaplan Curexema™ directly after getting out of the bath or shower while the skin is still damp.
Use Cremedify™ moisturizing body cleanser daily as part of your regular shower or bath routine.

Active ingredients

Emollients

Essential Fatty Acids: Nourishing Your Skin from Within

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Humectants

Essential Fatty Acids: Nourishing Your Skin from Within

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Glycerin

Essential Fatty Acids: Nourishing Your Skin from Within

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Niacinamide

Essential Fatty Acids: Nourishing Your Skin from Within

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Essential Fatty Acids

Essential Fatty Acids: Nourishing Your Skin from Within

Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.

Full ingredient list

White soft paraffin, glycerin, purified water, cetomacrogol, paraffinum liquidum, ethyl hexyl glycerin & phenoxyethanol, cetyl alcool, isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, niacinamide, decyl glucoside, lauryl glucoside, sodium hyaluronate.

Cremedify

R 440.00

Cremedify

product benefits

Barrier Repair

Physiological barrier repair by strengthening the skin's structural integrity, reducing sensitivity and increasing the skin's ability to defend against harmful agents

Hypoallergenic

Specifically formulated to avoid common allergens, reducing the risk of skin reactions and promoting healthy, irritation-free skin.

Soothes Irritated Skin

Soothes and calms irritated skin by reducing inflammation and providing immediate relief, helping to restore comfort and balance to distressed skin.

Control moisture balance

Reduces transepidermal water loss by reinforcing the skin's natural barrier, ensuring long-lasting hydration and protection against dryness.

cremedify

mode of action

Lipid-Bilayer Technology

DuraQuench IQ SA functions by forming an intelligent lipid bilayer on the skin's surface to regulate water loss and interacting with the lipid bilayers within the stratum corneum to reinforce the skin's natural barrier.

This dual-action mechanism helps retain moisture and enhance the skin's protective barrier, leading to prolonged skin hydration, reduced water loss under varying environmental conditions, and improved skin condition even after wash-off applications.

The intelligent lipid bilayer formed by DuraQuench IQ SA is achieved through a combination of specific ingredients that work synergistically.

Potassium Cetyl Phosphate: Contributes to the formation of lipid bilayers on the skin's surface.

Isostearyl Isostearate: Reinforces the skin's natural barrier.

Stearic Acid and Cetyl Stearate: Replenish long-chain fatty acids and esters typically depleted in dry skin.

Cetyl Alcohol: Assists in forming liquid crystals, enhancing the moisturizing effect and the stability of the lipid bilayer structure.

Ceramides

Ceramides play a crucial role in maintaining the skin's barrier function and overall health at the physiological level. Their mode of action involves several vital mechanisms:

Structural Role in Skin Barrier: The skin barrier, primarily located in the stratum corneum (the outermost layer of the skin), consists of corneocytes (dead skin cells) embedded in a lipid matrix. This matrix comprises ceramides, cholesterol, and free fatty acids in a specific ratio. Ceramides are the largest component and are essential for the barrier's structural integrity, functioning like the 'mortar' that holds the 'bricks' (corneocytes) together. By maintaining this structure, ceramides prevent excessive water loss and protect against the entry of harmful substances.
Hydration and Water Retention: Ceramides help the skin retain moisture by forming a protective layer that limits water evaporation. This is crucial for keeping the skin hydrated, plump, and resilient.
Regeneration and Repair: Ceramides can support the skin's natural repair processes, particularly after damage caused by environmental factors like UV radiation, pollution, and irritants. They help restore the barrier function, promoting healing and reducing the risk of skin conditions such as dermatitis and eczema.
Anti-inflammatory Properties: Some studies suggest that ceramides may possess anti-inflammatory properties. These properties help soothe irritated skin and reduce inflammation, beneficial in conditions like psoriasis and eczema.
Signaling Molecules: Beyond their structural role, ceramides also function as signaling molecules that can influence cell proliferation, differentiation, and apoptosis (programmed cell death). This is significant for skin homeostasis and maintaining a healthy skin barrier.

References:

Pilgram, G.S.K., Vissers, D.C.J., van der Meulen, H., Pavel, S., Lavrijsen, S.P.M., Bouwstra, J.A., Koerten, H.K. (2001). The effect of 2-hydroxyoctadecanoic acid on human skin and its role in dry skin conditions. Archives of Dermatological Research, 293(4), 191-197.
Elias, P.M., Wakefield, J.S. (2014). Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Clinical Reviews in Allergy & Immunology, 41(3), 282-295.
Uchida, Y. (2014). Ceramide signaling in mammalian epidermis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1841(3), 453-462.

These references highlight the critical role of ceramides in skin physiology, underpinning their use in dermatological products like Curexema for treating and managing dry skin conditions.

Emmolients

Main Benefits of Emollients

Hydration: Emollients fill in the gaps between skin cells that are missing moisture, effectively hydrating the skin. Replenishing lost water content helps to maintain the skin's natural moisture balance, making the skin feel softer and smoother.
Barrier Protection: They form a protective layer over the skin surface, which helps to prevent transepidermal water loss (TEWL), a common issue in dry and eczema-prone skin. This protective layer shields the skin from environmental irritants and allergens, reducing the risk of flare-ups and infections.
Skin Repair: Emollients help to repair the skin barrier function, which is often compromised in conditions like eczema, psoriasis, and dermatitis. By restoring the integrity of the skin barrier, emollients can improve the skin's resilience against irritants and reduce symptoms of itchiness and inflammation.
Flexibility and Elasticity: By keeping the skin moist, emollients increase its flexibility and elasticity, which can help to prevent cracks and fissures in dry or thickened skin areas. This is particularly beneficial in preventing the skin from becoming brittle and breaking, especially in areas prone to eczema or psoriasis.
Soothing Effect: Emollients have a soothing effect on the skin, relieving itching and discomfort associated with dryness and skin conditions. This can help to reduce scratching, which in turn prevents further skin damage and potential infections.
Enhanced Skin Appearance: Regular use of emollients can improve the appearance of the skin, making it look healthier and more vibrant. They can help to diminish the appearance of dry or flaky skin, providing a smoother and more even skin texture.

Emollients are beneficial for maintaining and restoring skin health, offering hydration, protection, and relief from various skin conditions. Their regular application is key in managing dry skin, enhancing skin barrier function, and improving overall skin appearance and comfort.

Occlusives

Occlusives form a protective layer on the skin's surface. This layer is a barrier, preventing water loss and shielding the skin from external irritants.

Main benefits of Occlusives

Prevention of Transepidermal Water Loss (TEWL): Occlusives create a physical barrier on the skin that prevents moisture from evaporating into the air. This is especially beneficial in dry environments where the skin is prone to losing moisture quickly.
Enhanced Skin Hydration: Occluives help prevent water loss and maintain and enhance the skin's hydration levels. This can lead to improved skin texture, making it feel smoother and softer.
Protection from Environmental Irritants: The barrier formed by occlusives can protect the skin from various environmental factors, such as wind, cold temperatures, and pollutants, which can strip the skin of its natural oils and lead to dryness and irritation.
Improved Skin Barrier Function: Regular use of occlusives can help to repair and strengthen the skin's natural barrier function. A healthy skin barrier is crucial for preventing the entry of pathogens and reducing the risk of skin infections and irritations.
Soothing Dry, Cracked Skin: Occlusives are particularly beneficial for dry, cracked, or chapped skin. They lock in moisture and provide a protective layer to promote healing and reduce discomfort.
Sealing in Other Moisturizing Ingredients: Occlusives are often used with other moisturizing agents, such as humectants and emollients. By sealing in these ingredients, occlusives enhance their effectiveness, ensuring that the skin remains hydrated for longer periods.

Humectants

Humectants has the unique ability to attract and retain moisture from the environment.

Main benefits of Humectants:

Hydration: Humectants draw water molecules into the skin's outer layer from deeper levels of the skin and, in humid environments, from the air. This hydration helps to improve skin's moisture levels, making it look and feel plump, hydrated, and supple.
Enhanced Skin Barrier: By promoting hydration, humectants contribute to a healthier skin barrier function. A well-hydrated skin barrier is more effective at protecting against environmental aggressors and less prone to irritation.
Reduction of Fine Lines and Wrinkles: The hydration provided by humectants can temporarily minimize the appearance of fine lines and wrinkles by plumping up the skin, leading to a smoother, more youthful complexion.
Improved Skin Texture: Humectants can help to smooth the skin's surface, leading to a softer feel and a more even appearance. This can be particularly beneficial for individuals with dry or flaky skin.
Promotion of Skin Cell Turnover: By maintaining optimal hydration levels, humectants can support the natural process of skin exfoliation and cell turnover, leading to healthier, more radiant skin.
Versatility: Humectants are suitable for a wide range of skin types, including oily and acne-prone skin, as they provide moisture without adding oiliness to the skin. This makes them an essential component in various skincare products tailored to different skin needs.

Fatty acids

Essential fatty acids (EFAs) offer a multifaceted approach to improving skin health in patients with eczema and dry skin conditions.

BIOCHEMICAL BRILLIANCE

Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier is a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.

PHARMACOLOGICAL ADVANTAGES

PHYSIOLOGICAL HARMONY

indications for Cremedify

Dermatitis / Eczema
Rough Skin Texture
Sensitive Skin
Ichthyosis
Psoriasis
Disrupted Skin Barrier
Dry Skin

Emollient-Rich and Lipid-Replenishing Body Cream Cleanser for Ichthyosis, Eczema, Psoriasis, and Other Dry Skin Conditions.

lipid bilayer technology

barrier function & repair

Dermaplan

testimonials

This product is life changing !!!

I have tried everything on the market and nothing worked. My skin was so sensitive and even prescript medicine and ointments did not work after years of chemo and radiation treatments. Thank you for changing my life and being comfortable in my own skin again. No more itchy, dry skin and no more inflammation. I will definitely order this product again and again.

Dermabase

I bought the pack for my daughter who is coming to visit from England for Christmas. So I haven’t used the treatment products. But the Dermabase is for me. And I love love love it. I used to have to apply cream to my skin twice a day and after swimming my skin was dry. Dermabase keeps my skin hydrated after one application for 24 hours. Even after a short swim. Very good product. I was raving about it so much that my other daughter also wanted one!

Eczema Prone Treatment pack

Groundbreaking!

At last a product in South Africa that ticks all the boxes. I have been struggling for 5 years with sensitivity and a very dry skin after treatments for melanoma. This product has changed my life in the past week. Thank you for the luxurious lotion that makes me feel comfortable in my own skin again❤️