DermExcel™

Salicylic Gel: Trial

Name: Salicylic Gel: Trial
Brand: DermExcel™
SKU: DX-SG05
Price: 136.00 ZAR
Availability: InStock

4.9 / 5.0 from 295 reviews

R 136.00

SIZE: 5 mL

↓ Sebum

Unclog Pores

Anti-Acne

↓ inflammation

Ingrown hair

Salicylic Gel is a scientifically formulated chemical exfoliating treatment enriched with 5% Salicylic acid, renowned for its potent anti-inflammatory, oil-regulating, and cell-resurfacing properties. This advanced gel is meticulously designed to combat acne and folliculitis by effectively inhibiting the growth of acne-causing bacteria. It efficiently reduces irritation and inflammation associated with these conditions, relieving troubled skin.

With its optimal concentration of Salicylic acid, Salicylic Gel clears existing acne and folliculitis lesions, promoting a smoother and healthier complexion. By gently exfoliating the skin's surface, it aids in cell turnover, diminishing the appearance of blemishes and scars over time.

Featuring its primary active ingredient, Salicylic acid, this targeted gel provides a safe and reliable solution to tackle breakouts effectively. Regulating the skin's sebum production helps prevent future breakouts, addressing the root cause of acne and folliculitis. Salicylic Gel is a valuable addition to any skincare routine, particularly for those seeking a scientifically backed solution to troublesome skin conditions.

Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

USE DURING PREGNANCY

The topical application of Salicylic acid on areas of concern is considered safe during pregnancy.

Most guidelines, including those from the American Academy of Dermatology and various obstetric authorities, suggest that topical Salicylic acid can be used during pregnancy.

Nevertheless, it is always recommended for pregnant women to consult with their healthcare provider before using any medication, including topical treatments.

SHIPPING

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RETURNS

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If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.

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Salicylic Gel: Trial

R 136.00

Acne: Clear existing lesions and prevent future breakouts. Its anti-inflammatory action reduce redness and inflammation associated with acne, while its oil-regulating effects help control sebum production.
Folliculitis: Help manage the inflammation of hair follicles and inhibit the growth of bacteria that contribute to folliculitis.
Oily skin: Regulate and control excessive sebum production, reducing shine and helping prevent clogged pores.
Rough Skin Texture: Enhance skin smoothness, minimize roughness, and refine the appearance of pores, resulting in a more even and refined complexion.
Congested Pores: Oil soluble and, therefore, able to penetrate the pores to dissolve oil and cell debris to unclog pores.
Psoriasis: Soften and remove scales associated with psoriasis due to its keratolytic action.
Keratosis Pilaris: Reduce the appearance of rough, bumpy skin associated with this condition.

Active ingredients

Salicylic acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Full ingredient list

Aqua, Propylene glycol, Glycolic acid, Glycerin, Polyacrylamide & C13-14 Isoparaffin & Laureth-7, Triethanolamine, Hydroxyethylcellulose, Potassium hydroxide

Evening

Application time: Evening.
Frequency: 2-3 times per week as tolerated by your skin, or follow your Dermal Diagnosis treatment plan instructions. Once an affected area becomes clear, occasional use will maintain remission.

1. Cleanse

Start with clean and dry skin.
Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2: Apply

Dispense a small amount of product onto your fingertips.
Apply evenly over your face or on body areas of concern.
Avoid sensitive areas, e.g., the eyes and lips.

Important note

Start by applying this exfoliator one evening per week. After one week, increase usage to two evenings a week.
Observe how your skin responds and adjust usage accordingly.
You may use this treatment every second night if you don't have sensitive skin.
Don't apply any other product to the area treated with your exfoliating treatment. The other product may alter the pH of the active ingredients, lowering the product's potency.
This exfoliating treatment promotes skin peeling by effectively removing dead skin cells. Peeling is a normal reaction and not a sign of skin dryness. You should notice decreased peeling as the product works to exfoliate dead skin.
You may notice a slight stickiness on your skin after applying your exfoliating product. This sensation is typical due to the hydroxyethylcellulose, a thickening agent that helps the treatment adhere to the skin. This allows the active ingredients to work effectively throughout the night by promoting exfoliation and cell turnover. Embrace this as a sign that the active ingredients are set to rejuvenate your skin while you sleep without the inconvenience of daytime residue.
Always use SPF 30 or greater during the day.

Salicylic Gel: Trial

product benefits

Targeted Acne Treatment

Promote cellular turnover, reduce pore congestion, eliminate acne-causing bacteria, and down-regulate inflammation, resulting in a smooth and healthy complexion.

Unblock clogged pores

Penetrate deeply into the pores to dissolve excess sebum and debris, thereby reducing pore blockage and minimizing the risk of acne formation and enlarged pores.

Anti-Microbial

Manage microbial activity by inhibiting the growth of pathogenic bacteria, balancing the skin's microbiome, and reducing the risk of infections and inflammation.

Anti-inflammatory

Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.

Improve Skin Texture

Smooth out uneven skin surfaces by promoting consistent cell turnover, reducing rough patches, and improving the skin's overall tactile and visual texture.

Minimize Pores

Remove excess oil and dead skin cells and improve skin texture to minimize the appearance of enlarged pores.

salicylic gel

mode of action

Unclog Pores

Salicylic acid is lipophilic, which means it can penetrate oily skin and clogged pores, resulting in deep cleaning.
Decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.

Anti-Aging

Salicylic acid brightens the complexion. It acts as an exfoliant by softening and dissolving keratin, thus allowing dead skin cells to shed naturally.
Studies have indicated that salicylic acid's exfoliating properties reduce the appearance of fine lines and wrinkles. Over time, exfoliation helps to reduce the thickness of the layer of dead skin cells, giving the skin a brighter, more glowing appearance.

Regulate Sebum (oil)

Salicylic acid works well to balance sebum levels because it is lipid or oil-soluble. So, rather than remaining on the skin's surface, Salicylic acid penetrates deep into sebum-filled pores.

Microbial Control

It inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis. Therefore, salicylic acid may neutralize the bacteria C. acnes in blemishes.

anti-inflammatory & anti-acne

Salicylic acid reduces sebum secretion.
Salicylic acid has potent anti-inflammatory effects, inhibiting the arachidonic acid cascade.
Salicylic acid reduces inflammation by modulating COX2 gene expression to decrease the formation of pro-inflammatory cytokines.

Exfoliating

Salicylic acid works well to balance sebum levels because it is lipid or oil-soluble. So, rather than remaining on the skin's surface, Salicylic acid penetrates deep into sebum-filled pores.
Salicylic acid works by loosening and breaking apart desmosomes (attachments between cells in the outer layers of the skin). This action encourages the exfoliation of dead and damaged skin and unclogging pores.
Disrupts cellular junctions to exfoliate dead skin cells.

indications for Salicylic Gel: Trial

Clogged Pores
Enlarged Pores
Shaving Bumps
ingrown hair
Folliculitis
Facial and Body Acne
Inflammation
blackheads
whiteheads
Seborrheic Dermatitis

Effective acne control by penetrating pores to dissolve excess oil and dead skin cells, preventing clogged pores and reducing the frequency of breakouts.

FDA OTC Drug Monograph

Salicylic acid 3%

The US Food and Drug Administration (FDA) approves salicylic acid in OTC drug products.

In addition to being FDA-approved as a safe and effective acne drug, it is also approved for use in OTC drugs for corn, callus, wart removal, and anti-dandruff drug products.

FDA Category

Indication

CFR 21, 333.310

acne

CFR 21, 358.710 (b)

Seborrheic dermatitis

CFR 21, 358.710 (c)

Psoriasis

salicylic acid

pore clearing action

Sebum (oil) and dead skin cells accumulate inside the pores, causing blackheads and whiteheads.

Salicylic acid has the unique ability to penetrate the pores and to dissolve and extract the oil and dead skin cell plug.

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the stages of acne

Step 1

Regulate sebum (oil) production and secretion

The excretion of lipids by the sebaceous glands is controlled hormonally.
The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
Hormones continue to affect sebaceous gland activity into adulthood.

Step 2

Prevent and remove content build-up in pores

The first stage of acne is called comedogenesis (formation of comedones).
The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
This is caused by several factors, including increased amounts of sebum, inflammation of the sides of the hair follicle preventing the release of the exfoliated keratinocytes, and increased cohesion of keratinocytes.
Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris (dead skin cells) in the pores and follicles.

Step 3

Prevent Bacterial Infiltration and infection

The keratinocyte plug and sebum provide excellent food sources for bacteria.
The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.
Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.

Step 4

Down-regulate and prevent inflammation

Inflammation continues with increased redness and pus.
This is clinically detectable as a papule or pustule.
Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
Salicylic acid suppresses pro-inflammatory cytokine expression.

Rosacea

Stages and treatment objectives

The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.

Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

Normal Skin

Healthy skin with a perfect balance between normal microflora and skin receptors.
Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
These receptors should not trigger an immune response by binding to normal microflora.

Phase 1

PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

Phase 2

Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.

Phase 3

The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

salicylic acid as rosacea and acne treatment

anti-inflammatory

Inhibit the inflammation that leads to breakouts, redness, and skin damage.

Anti-bacterial

Inhibits bacteria responsible for causing and aggravating acne and rosacea.

Comedolytic

Unclog pores by dissolving and extracting dirt, oil, and cellular debris.

Keratolytic

Disrupts cellular junctions to exfoliate dead skin, revealing bright, new cells.

salicylic acid targets all phases of the acne process

Sebum over-production

Process

The first step in forming a blemish involves sebum, a naturally occurring oily substance that moisturizes, lubricates, and protects the skin and hair. While sebum production is normal, too much can lead to clogged pores.

______

Targeted treatment

Salicylic acid balances sebum levels because it is lipid or oil-soluble. So, rather than remaining on the skin's surface, salicylic acid penetrates deep into sebum-filled pores.

Clogged pores

Process

The next step in the development of acne is triggered when the skin's follicles are not exfoliating properly. This means keratin, a protein found within the skin, and sebum clog the follicle.

______

Targeted treatment

Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.
Salicylic acid disrupts cellular junctions to exfoliate dead skin cells.

Bacterial infiltration

Process

When the follicle becomes clogged, a species of bacteria called Cutibacterium acnes (formerly Propionibacterium acnes) accumulates and multiplies in the follicle.

______

Targeted treatment

Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.

Inflammation

Process

After bacterial infiltration the follicle becomes inflamed, thus leading to pimple formation.

______

Targeted treatment

Salicylic acid suppresses pro-inflammatory cytokine expression.
Salicylic acid inhibits the arachidonic acid cascade.

Sebum over-production

Process

The first step in forming a blemish involves sebum, a naturally occurring oily substance that moisturizes, lubricates, and protects the skin and hair. While sebum production is normal, too much can lead to clogged pores.

______

Targeted treatment

Salicylic acid balances sebum levels because it is lipid or oil-soluble. So, rather than remaining on the skin's surface, salicylic acid penetrates deep into sebum-filled pores.

Clogged pores

Process

The next step in the development of acne is triggered when the skin's follicles are not exfoliating properly. This means keratin, a protein found within the skin, and sebum clog the follicle.

______

Targeted treatment

Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.
Salicylic acid disrupts cellular junctions to exfoliate dead skin cells.

Bacterial infiltration

Process

When the follicle becomes clogged, a species of bacteria called Cutibacterium acnes (formerly Propionibacterium acnes) accumulates and multiplies in the follicle.

______

Targeted treatment

Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.

Inflammation

Process

After bacterial infiltration the follicle becomes inflamed, thus leading to pimple formation.

______

Targeted treatment

Salicylic acid suppresses pro-inflammatory cytokine expression.
Salicylic acid inhibits the arachidonic acid cascade.

testimonials

Glycolic gel

Dit help beslis vir my vel...so sag en definitief minder plooie!!

Dermalytic

I always had this cracked and dried heels and since a friend of mine introduced me to this amazing product my feet are soft and without any cracks. Super satisfied with this product. Thank you so much Dermexcel

Lovely

Excellent product....made my skin wow

Glycolic gel

Just started using it, let me give it some few months to check whether it's working or not.

It didn't work for me

Bottle filled with awesomeness!!

What a great product!!

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Salicylic Gel: Trial