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DermExcel™ | Retinol Serum
DermExcel™ | Retinol serum
Retinol Serum Retinol Serum Retinol Serum Retinol Serum
DermExcel™

Retinol Serum

Sale price R 1,059.13
4.9 / 5.0 from 2665 reviews

Pay interest-free installments from R 264.78 with various payment gateways selected at checkout.

SIZE: 30 mL

Unclog Pores

Unclog Pores

Minimize Pores

Minimize Pores

Smooth Skin

Smooth Skin

anti-aging

anti-aging

DNA repair

DNA repair

An advanced skincare formula that leverages the potency of active ingredients like Hydroxypinacolone Retinoate, Niacinamide, and Acetyl Hexapeptide-8.

Hydroxypinacolone Retinoate, a form of retinoid, works at the cellular level to stimulate epidermal growth, counteracting both intrinsic and extrinsic signs of aging. It aids in reducing hyperpigmentation and evening skin tone while promoting the development of collagen and elastin, proteins that are vital for maintaining skin's elasticity and structure.

Another key ingredient, Niacinamide, is instrumental in supporting cell health in the skin. It helps build and protect skin cells from environmental stresses like sunlight, pollution, and toxins while also significantly supporting acne treatment.

Acetyl Hexapeptide-8, a synthetic peptide, adds to the formula's efficacy by slowing down muscle movement in the face, thus decreasing the appearance of wrinkles and expression lines. It enhances collagen production, which firms the skin and increases its elasticity. Additionally, it provides hydration, keeping the skin well-moisturized.

DermExcel Retinol Serum stimulates collagen production, reduces inflammation, inhibits pigmentation, and accelerates cell turnover, all contributing to a healthier and more youthful complexion. It also aids in reducing sebum production and unclogging pores, making it a potent tool in the battle against acne.

Retinoic acid analogue

Retinoic acid analogue

Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

Physiological Effects

  • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
  • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
  • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
  • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
  • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
  • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

Special Benefits

  • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
  • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
  • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
  • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
  • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

References

  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
  • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
  • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
  • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Niacinamide

Niacinamide

Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

Physiological Effects

  • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
  • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
  • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
  • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
  • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
  • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

Managing Dermatological Conditions

  • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
  • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
  • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
  • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
  • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

References

  • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
  • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
  • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
  • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Peptides

Peptides

Peptides are short chains of amino acids with a wide range of biological functions and skin benefits. They are essentially small fragments of proteins, which are fundamental components of all living cells, including collagen and elastin in the skin.

In skincare, peptides are known for enhancing skin repair and rejuvenation. They function as signaling molecules, instructing cells to perform specific tasks such as producing collagen and elastin, vital for maintaining the skin's firmness and elasticity. This makes peptides especially beneficial in anti-aging products, as they can help reduce the appearance of fine lines and wrinkles.

Research has shown that certain peptides can improve skin barrier function, increase hydration, and soothe skin inflammation. This makes them suitable for products targeting dry, sensitive, or inflamed skin.

Peptides, with their diverse functions in promoting collagen production, strengthening the skin barrier, wound healing, and anti-inflammatory actions, are pivotal in managing various dermatological conditions, particularly in anti-aging, sensitive skin care, and wound healing applications.

Physiological Effects

  • Collagen Production: Certain peptides, known as signal peptides, stimulate collagen production in the skin, enhancing skin firmness and reducing the appearance of fine lines and wrinkles.
  • Skin Barrier Strengthening: Peptides can strengthen the skin barrier, improve hydration, and protect against environmental damage.
  • Wound Healing: Some peptides play a role in the skin's natural healing process, aiding tissue repair and regeneration.
  • Anti-Inflammatory Effects: Certain peptides have anti-inflammatory properties, helping to soothe and calm irritated skin.
  • Antimicrobial Action: Some peptides possess antimicrobial properties, potentially helping to manage acne and other skin infections.

Managing Dermatological Conditions

  • Aging Skin: Peptides can stimulate collagen production and improve skin elasticity.
  • Sensitive Skin Conditions: Peptides are beneficial for sensitive or inflamed skin due to their soothing properties.
  • Acne-Prone Skin: Antimicrobial peptides can be effective in acne treatment formulations.
  • Wound Care and Repair: Peptides improve wound healing and reduce scarring.

References

  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
  • Schagen, S. K. (2012). Topical peptide treatments with effective anti-aging results. Cosmetics.
  • Varani, J., et al. (2001). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Journal of Investigative Dermatology.
Matrixyl 3000

Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.

Physiological Effects

  • Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
  • Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
  • Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
  • Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.

Managing Dermatological Conditions

  • Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
  • Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
  • Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.

Biochemical Mechanism and Clinical Efficacy

Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.

References

  1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
  2. Sederma Inc., "Matrixyl 3000 Technical Overview."
  • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
  • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
  • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Acetyl Hexapeptide-8

Acetyl Hexapeptide-8
Acetyl Hexapeptide-8: The Innovative Peptide in Anti-Aging Dermatology

Acetyl Hexapeptide-8 is a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

Biochemical Mechanism

Acetyl Hexapeptide-8 functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.

Physiological Effects

  • Neurotransmitter Inhibition: Acetyl Hexapeptide-8 works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
  • Reduction of Expression Lines: Helps to reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
  • Improvement in Skin Texture: Regular use can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.

Special Benefits

Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Acetyl Hexapeptide-8 in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Acetyl Hexapeptide-8 reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).

References

  • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
  • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
  • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Retinol Serum Retinol Serum Retinol Serum Retinol Serum
DermExcel™ | Retinol Serum
Retinol Serum Sale priceR 1,059.13
  • Stimulate collagen production, the protein that gives the skin structure and elasticity. This helps reduce the appearance of wrinkles and fine lines.
  • Reduces hyperpigmentation and dark spots, leading to a more even skin tone.
  • Protects skin cells from environmental stresses such as sunlight, pollution, and toxins​.
  • Decreases wrinkles and expression lines by slowing down the movement of facial muscles.
  • Reduce and prevent pigmentation by inhibiting the enzymes responsible for pigmentation.
  • Promotes skin hydration by enhancing the skin's ability to retain moisture, leading to a healthier and more youthful appearance​.
  • Accelerates cell turnover by promoting faster cell turnover. This helps the skin to rejuvenate faster, revealing healthier, fresher skin cells.
  • Regulate sebum production to help unclog pores and reduce the risk of acne outbreaks.
  • Reduce inflammation: Anti-inflammatory action improves skin texture and appearance and helps mitigate acne formation.
  • Improves DNA communication between cells: It assists in reversing DNA damage that causes skin aging and prevents cells from clumping and sticking together inside pores.
Evening

Apply in the evening on cleansed skin.

1. Cleanse
  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2. Apply
  • Take a small amount of serum (1-2 pumps or a pea-sized amount should suffice) and gently apply it to the face.
  • Using your fingertips, gently massage the serum into your skin in a circular motion. This helps to ensure the serum is evenly distributed and absorbed.

3. Wait
  • Allow the serum to absorb fully into the skin before applying other skincare products. This typically takes 1-2 minutes.

Important notes
  • Clean skin: The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
  • Damp skin: After cleansing your face, don't completely dry your skin; leave it slightly damp. The best time to apply the serum is when your skin is still slightly damp after cleansing. This allows your skin to better absorb the potent ingredients in the serum.
  • Less is more: serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.

Active ingredients
  • Retinoic acid analogue

    • Retinoic acid analogue

    Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.

    Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.

    Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.

    Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.

    Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.

    HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.

    Physiological Effects

    • Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
    • Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
    • Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
    • Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
    • Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
    • Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.

    Special Benefits

    • Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
    • Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
    • Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
    • Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
    • Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.

    References

    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
    • Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
    • Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
    • Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
  • Niacinamide

    • Niacinamide

    Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.

    Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.

    Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.

    The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.

    Physiological Effects

    • Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
    • Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
    • Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
    • Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
    • Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
    • Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.

    Managing Dermatological Conditions

    • Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
    • Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
    • Aging Skin: Niacinamide targets wrinkles and loss of firmness.
    • Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
    • Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.

    References

    • Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
    • Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
    • Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
    • Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
  • Peptides

    • Peptides

    Peptides are short chains of amino acids with a wide range of biological functions and skin benefits. They are essentially small fragments of proteins, which are fundamental components of all living cells, including collagen and elastin in the skin.

    In skincare, peptides are known for enhancing skin repair and rejuvenation. They function as signaling molecules, instructing cells to perform specific tasks such as producing collagen and elastin, vital for maintaining the skin's firmness and elasticity. This makes peptides especially beneficial in anti-aging products, as they can help reduce the appearance of fine lines and wrinkles.

    Research has shown that certain peptides can improve skin barrier function, increase hydration, and soothe skin inflammation. This makes them suitable for products targeting dry, sensitive, or inflamed skin.

    Peptides, with their diverse functions in promoting collagen production, strengthening the skin barrier, wound healing, and anti-inflammatory actions, are pivotal in managing various dermatological conditions, particularly in anti-aging, sensitive skin care, and wound healing applications.

    Physiological Effects

    • Collagen Production: Certain peptides, known as signal peptides, stimulate collagen production in the skin, enhancing skin firmness and reducing the appearance of fine lines and wrinkles.
    • Skin Barrier Strengthening: Peptides can strengthen the skin barrier, improve hydration, and protect against environmental damage.
    • Wound Healing: Some peptides play a role in the skin's natural healing process, aiding tissue repair and regeneration.
    • Anti-Inflammatory Effects: Certain peptides have anti-inflammatory properties, helping to soothe and calm irritated skin.
    • Antimicrobial Action: Some peptides possess antimicrobial properties, potentially helping to manage acne and other skin infections.

    Managing Dermatological Conditions

    • Aging Skin: Peptides can stimulate collagen production and improve skin elasticity.
    • Sensitive Skin Conditions: Peptides are beneficial for sensitive or inflamed skin due to their soothing properties.
    • Acne-Prone Skin: Antimicrobial peptides can be effective in acne treatment formulations.
    • Wound Care and Repair: Peptides improve wound healing and reduce scarring.

    References

    • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
    • Schagen, S. K. (2012). Topical peptide treatments with effective anti-aging results. Cosmetics.
    • Varani, J., et al. (2001). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Journal of Investigative Dermatology.
  • Matrixyl 3000

    • Matrixyl 3000
    Matrixyl 3000: The Powerhouse of Anti-Aging Peptides

    Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.

    Physiological Effects

    • Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
    • Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
    • Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
    • Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.

    Managing Dermatological Conditions

    • Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
    • Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
    • Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.

    Biochemical Mechanism and Clinical Efficacy

    Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.

    Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).

    Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.

    References

    1. Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
    2. Sederma Inc., "Matrixyl 3000 Technical Overview."
    • Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
    • Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
    • Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
  • Acetyl Hexapeptide-8

    • Acetyl Hexapeptide-8
    Acetyl Hexapeptide-8: The Innovative Peptide in Anti-Aging Dermatology

    Acetyl Hexapeptide-8 is a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.

    Biochemical Mechanism

    Acetyl Hexapeptide-8 functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.

    Physiological Effects

    • Neurotransmitter Inhibition: Acetyl Hexapeptide-8 works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
    • Reduction of Expression Lines: Helps to reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
    • Improvement in Skin Texture: Regular use can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.

    Special Benefits

    Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Acetyl Hexapeptide-8 in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Acetyl Hexapeptide-8 reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).

    References

    • Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
    • Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
    • Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.

Full Ingredient list

    Aqua, Niacinamide, Acetyl Hexapeptide-8 & Caprylyl Glycol, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Glycerin, Hydroxypropyl Cyclodextrin & Palmitoyl Tripeptide-38, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Acrylates copolymer, Glycerin, C14-22 Alkane, Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate

Retinol Serum

product benefits

Boost Collagen Production

Boost Collagen Production

Restore skin structure by stimulating fibroblast activity and supporting the synthesis of new collagen fibers, improving skin firmness and elasticity.

Pigmentation treatment

Pigmentation treatment

Interfere with pigment production pathways and encourage the removal of discolored cells, resulting in a significant reduction in dark spots and a more even skin tone.

Improve Skin Cell DNA

Improve Skin Cell DNA

Retinol enhances and optimizes cell DNA communication, promoting healthier cellular behavior and improving physiological function.

Decrease Lines & Wrinkles

Decrease Lines & Wrinkles

Leverage Argireline to target dynamic wrinkles, minimizing their formation and depth through the inhibition of neurotransmitter release. This helps prevent the deepening of fine lines over time.

Refine Skin Texture & Pores

Refine Skin Texture & Pores

Promote healthy skin cell regeneration and optimize the skin's structural integrity to refine skin texture and diminish pore size, resulting in a more even, smooth, and polished look.

Enhance skin renewal

Enhance skin renewal

Enhance the skin's renewal process, replacing older, damaged cells with newer, healthier ones. The proliferation of new skin cells refines the skin's surface, diminishes signs of aging, and improves overall skin clarity.

Promote Skin Hydration

Promote Skin Hydration

Enhance the skin barrier function, reducing moisture loss and maintaining optimal hydration levels for smoother, more supple skin.

Anti-inflammatory

Anti-inflammatory

Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.

Skin barrier enhancement

Skin barrier enhancement

Stimulate barrier lipids synthesis, improving skin elasticity to ensure a robust defense against environmental damage.

Sebum Regulation

Sebum Regulation

Implement effective sebum regulation strategies to minimize complications and refine the visual condition of oily skin.

Indications for Retinol Serum

Aging Skin
Volume loss
DNA Protection
Rough Skin Texture
Acne / Breakouts
Clogged Pores
Rosacea / Red Skin
Inflammation
Sensitive Skin
Enlarged Pores
Stimulate collagen production
Diminish hyperpigmentation
Promote healthy skin cell communication
Reduce inflammation
Accelerate cell turnover

Retinol

Mode of action

retinoid molecule comparison

DermExcel Retinol Serum contains 3% GranActive Retinoid - Hydroxypinacolone Retinoate (HPR).

Hydroxypinacolone Retinoate (HPR)

Traditional Retinol

Retinaldehyde

Retinoic acid

stability

very high
moderate
low
low

irritation

low
moderate
high
very high

Efficacy

high
moderate
high
very high

key notes

  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.
  • Requires a two-step conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.
  • Requires a one-step conversion to Retinoic acid in the skin to be moderately effective.
  • High risk of irritation.
  • Very effective with no need for conversion, as it is already in its active form.
  • Binds directly to RA receptors.
  • Binds directly to RX receptors, which contributes to its very high risk for irritation.
  • Only available in pharmacies with a prescription from a medical doctor.

Hydroxypinacolone Retinoate (HPR)

stability

very high

irritation

low

Efficacy

high

key notes

  • Effective with no need for conversion to Retinoic acid in the skin.
  • Binds directly to RA receptors.
  • Low risk for irritation.

Traditional Retinol

stability

moderate

irritation

moderate

Efficacy

moderate

key notes

  • Requires a two-step conversion to Retinoic acid in the skin to be moderately effective.
  • Moderate risk for irritation.

Retinaldehyde

stability

low

irritation

high

Efficacy

high

key notes

  • Requires a one-step conversion to Retinoic acid in the skin to be moderately effective.
  • High risk of irritation.

Retinoic acid

stability

low

irritation

very high

Efficacy

very high

key notes

  • Very effective with no need for conversion, as it is already in its active form.
  • Binds directly to RA receptors.
  • Binds directly to RX receptors, which contributes to its very high risk for irritation.
  • Only available in pharmacies with a prescription from a medical doctor.

Testimonials

Customer Reviews

Based on 2665 reviews
95%
(2539)
4%
(95)
1%
(28)
0%
(3)
0%
(0)
L
Larissa van der Merwe
Retinol Serum

I have been using Dermel Health products for a few years and it has absolutely changed my skin. The Retinol Serum has evened out all my fine lines and made my skin look much younger, smooth and soft and even. It has also helped prevent mild breakouts that I used to get. These products really work.

E
Etrezia Lombard
Inflacin seeum

Good product. Because I am working outside I am only using it at night an make sure I have sunscreen on during the day

Y
Yolandie Van Schalkwyk
Life changing

What an awesome serum. Started seeing results from day 7. So impressed. I had very litte sensitivity, no peeling or excessive dry skin at all.

R
Rianli Badenhorst
Inflacin

Inflacin has completely tranformed my skin. It heals, regulates and makes my skin glow. I would highly recommend this product for anyone with sensitve acne prone skin.

G
Gcobisa Beshe
Inflating serum

My skin loves this serum

J
Jill King
Serum

I've been using my products daily. So far I really like them!

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