- Dry and dehydrated skin
- Impaired skin barrier
- Aging skin with loss of elasticity
- Eczema / Dermatitis or Allergy prone skin
- Mature, dry skin (60+ years) with low natural moisturising factor levels
SKIN BARRIER COMPONENTS:
- Ceramides
- Cholesterol
- Free Fatty Acids
- Lipid Bilayer Technology
HUMECTANTS:
- Hyaluronic acid
- d-Panthenol
- Glycerin
- Lipid Bilayer Technology
OCCLUSIVES:
- Medilan™
- Liquid paraffin
EMOLLIENTS:
- Ceramides
- Stearic acid
- Cetomacrogol
- Lipid Bilayer Technology
SUPPORTIVE ACTIVE INGREDIENTS:
- Niacinamide
FULL INGREDIENT LIST:
Aqua, white soft paraffin, extra pure lanolin, emulsifying wax, glycerin, stearic acid, ceramides, cholesterol, liquid paraffin, niacinamide, cetyl alcohol, cetomacrogol, isostearyl isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, ethyl hexyl glycerin, phenoxyethanol, carbomer, d-panthenol, sodium hyaluronate, C12-17 alkane, triethanolamine.
TIME OF APPLICATION:
- Apply in the morning and/or evening on cleansed skin after treatment serums.
FREQUENCY OF APPLICATION:
- Use daily and/or evening or follow your Dermal Diagnosis treatment plan directions.
FOLLOW THESE DIRECTIONS TO GET THE MOST OUT OF YOUR MOISTURISER:
- Apply Enriched to damp skin.
Moisturisers are most effective if you use them while your skin is still damp because damp skin absorbs the product more readily. That also gives the moisturiser a chance to lock in that hydration.
INDICATIONS FOR ENRICHED™

- Impaired or damaged skin barrier function
- Slight to severe flaking skin, which causes an ashy look affecting dry brown and black skin
- Dermatitis / Eczema
- Severly dry or dehydrated skin
- Mature dry or dehydrated skin - 60+ years
- Dry Rosacea and/or Dry Allergy prone skin
- Itchiness (pruritus) / Ichthyosis
- Impaired or damaged skin barrier function
- Slight to severe flaking skin, which causes an ashy
look affecting dry brown and black skin - Dermatitis / Eczema
- Severly dry or dehydrated skin
- Mature dry or dehydrated skin - 60+ years
- Dry Rosacea and/or Dry Allergy prone skin
- Itchiness (pruritus) / Ichthyosis
WHAT IS DRY SKIN?
- Dry skin is characterised by the lack of moisture in the stratum corneum (SC). This is the outermost skin layer.
- Water is the major softener of the skin, and when levels are low, cracks and fissures occur.
- For the skin to appear and feel normal, the water content of the SC must be greater than 10%.
- A disruption or defect in the skin's permeability barrier, allows excessive water to be lost from within the skin into the atmosphere. Referred to as transepidermal water loss (TEWL).
- When skin becomes too dry, the outer skin layers stiffen and may develop cracks. The cracks become fissures in the skin that become irritated, inflamed, and itchy.
TREATMENT OBJECTIVES FOR DRY SKIN WITH BARRIER IMPAIRMENT

Physiological Barrier Repair with Lipid-based, Ceramide-dominant therapy.

Increase the moisture content of the epidermis with Humectants.

The skin barrier fills the gaps between skin cells and replaces missing lipids with Emollients.

Create a protective layer on top of the skin to prevent water loss and “seal” in moisture with Occlucives.

Increase cellular turnover by hydrating skin with Emollients.

Relieve skin itching skin by increasing the skin's natural moisturising factor.
SKIN BARRIER FUNCTION


The 2 PRIMARY FUNCTIONS OF THE skin barrier
- PERMEABILITY BARRIER: Creating a barrier against electrolytes- and moisture loss (TEWL - Trans-epidermal Water loss)
- ANTIMICROBIAL BARRIER: Creating a barrier against the entry of unwanted microorganisms such as allergens and irritants. This function protects the skin against irritant dermatitis and skin infections.


Both of these barriers are localised primarily to the stratum corneum layer of the epidermis (the outermost layer of the skin).
When these barrier functions are impaired, the result is: DRY SKIN
When these barrier functions are impaired, the result is: DRY SKIN
The 2 PRIMARY FUNCTIONS OF THE skin barrier




PERMEABILITY BARRIER
Creating a barrier against electrolytes- and moisture loss (TEWL - Trans-epidermal Water loss).
This function protects the skin against becoming dry.


ANTIMICROBIAL BARRIER
Creating a barrier against the entry of unwanted micro-organisms such as allergens and irritants.
This function protects the skin against irritant dermatitis and skin infections.

PERMEABILITY BARRIER
Creating a barrier against electrolytes- and moisture loss
(TEWL - Trans-epidermal Water loss).
This function protects the skin against becoming dry.

ANTIMICROBIAL BARRIER
Creating a barrier against the entry of unwanted microorganisms such as allergens and irritants.
This function protects the skin against irritant dermatitis and skin infections.
Both of these barriers are localised primarily to the stratum corneum layer of the epidermis (the outermost layer of the skin).
When these barrier functions are impaired, the result is: DRY SKIN
When these barrier functions are impaired, the result is:
DRY SKIN
These barriers are localized primarily to the epidermis's stratum corneum layer (the skin's outermost layer).
When these barrier functions are impaired, the result is: DRY SKIN
Skin Barrier Impairment results in:
DRY SKINENRICHED™ MOISTURISER CLASSES MODE OF ACTION
TRIPLE PHYSIOLOGIC LIPID-BASED BARRIER REPAIR THERAPY





- Unlike moisturisers, topical triple physiologic lipid-based technology amplifies lipid production and replenishes the lamellar bilayers that are critical for normal barrier function and antimicrobial defence.
- Topically applied physiologic lipids, in contrast to moisturisers, do not form an occlusive layer on the SC surface. Instead, they are quickly absorbed into the underlying nucleated cell layers, where they incorporate into lamellar bodies.
- This Barrier Repair Therapy furthermore reduce inflammation by several mechanisms.
- This leads to a smoother surface with less friction and greater light refraction.
Physiologically replenish the lipid bilayers that are critical for normal barrier function and antimicrobial defence.
EMOLLIENTS





- Emollients soften and smooth the skin.
- They function by filling the gaps between skin cells and replace missing lipids.
- Emollients flatten the curled edges of the individual skin cells (corneocytes).
- This leads to a smoother surface with less friction and greater light refraction.
Fill the gaps between skin cells and replace missing lipids.
HUMECTANTS





- Humectants are water-soluble materials with high water absorption capabilities.
- Draw moisture from the air into the skin and/or draw moisture from the dermis into the epidermis.
- The attract water from the atmosphere and from the underlying dermis into the epidermis (outer skin layer).
- Although humectants may draw water from the environment to help hydrate the skin, in low-humidity conditions they may take water from the deeper epidermis and dermis resulting in increased skin dryness. For this reason, they work better when combined with occlusives.
Draw moisture from the air into the skin and/or draw moisture from the underlying dermis into the epidermis.
OCCLUSIVES



- Occlusives create a protective layer on top of the skin that prevent water loss and “seal” in moisture.
- Occlusives coat the stratum corner (outermost skin layer) to retard transepidermal water loss (TEWL).
- Occlusives is one of the best choices to treat dry skin because it provides an emollient effect as well as decreases TEWL.
- Occlusive agents are only effective while present on the skin; once removed, TEWL returns to the previous level.
Creates a protective layer on top of the skin that prevents water loss and “seals” in moisture.
ENRICHED™ BENEFITS BEYOND MOISTURISATION
Barrier Repair and Eczema treatment:
- Niacinamide increases barrier layer proteins such as involucrin, filaggrin and keratin. Filaggrin is critical in the formation of natural skin moisturising factors.
- Niacinamide provides long-lasting protection against the invasion of bacteria by activating an AMP (Antimicrobial Peptide) response.
- Stimulates the synthesis of ceramides and other intercellular lipids, decreasing trans-epidermal water loss (TEWL) and strengthening the skin's barrier against irritants and allergens.
- Aquaporin 3 is a gene that encodes water-permeable channels. The upregulation of aquaporin 3 is associated with Atopic Dermatitis / Eczema (AD), which leads to water loss through the skin. Niacinamide prevents the upregulation of aquaporin 3, thereby decreasing water permeability and water loss.
- Eczema/Atopic Dermatitis (AD) is an inflammatory skin condition. Niacinamide has anti-inflammatory properties by inhibiting PARP-1 and the associated expression of inflammatory cytokines, chemokines, adhesion molecules and inflammatory mediators.
- Increased cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) contributes to increased histamine and IgE levels in Atopic Dermatitis.
Niacinamide inhibits cAMP PDE and stabilises mast cells, thereby reversing the increased histamine and IgE levels in Atopic Dermatitis.
Inhibit hyperpigmentation:
- Prevents DNA damage through antioxidant activity.
- Prevent melanosome transfer from melanocytes to surrounding skin cells.
Treating inflammatory skin conditions:
- Reduce the inflammatory response by inhibiting inflammatory messengers.
- Provides long-lasting protection against bacteria through activation of anti-microbial peptides
Treating and preventing premature skin aging and improving skin barrier function:
- Stimulate collagen synthesis and significantly increase skin elasticity.
- Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
- Prevents DNA damage through antioxidant activity.
- Increases production of ceramides as well as other stratum corneum lipids to improve skin barrier funtion.
- Niacinamide boosts cellular energy and may enhance energy-dependent cellular processes such as DNA repair.
- Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body, including wound repair, cell migration, and cell signalling.
- With age, hyaluronic acid in the skin decreases sharply, resulting in a loss of hydration, volume and plumpness. Lines and wrinkles also appear, leaving skin looking dull and lacklustre.
- Hyaluronic acid comes in various molecular sizes. Larger molecules stay on the surface and give the skin a ‘dewy’ look, while smaller molecules penetrate deeper into the skin to deliver their hydration and plumping benefits.
- The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
- High molecular weight (HMW-HA): Doesn't penetrate the epidermis. It moisturizes the skin's surface, protects the skin's barrier, and improves skin elasticity, it also has anti-inflammatory properties to soothe sensitive or irritated skin
Very low molecular weight: Penetrate the skin efficiently but can induce a pro-inflammatory response.
Low molecular weight HA [50 kDa]: Penetrates into the skin well and does not cause inflammation.
Hydration:
- Hyaluronic acid can bind water up to 1000 times its volume and contributes to cellular growth, adhesion, and membrane receptor function.
- Hyaluronic acid reinforces the intercellular structures and produces the elastoviscous fluid matrix that firmly envelops collagen and elastin fibres.
- Hyaluronic acid holds moisture and provides firmness and radiance to the skin.
Anti-aging:
- Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
- Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes.
- Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
- In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
- Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity.
Promotes wound healing:
- D-Panthenol is part of medical wound-healing formulations for its ability to help treat skin injuries, burns, and sunburn.
- D-Panthenol is also beneficial after medical and cosmetic surgeries for its wound healing properties.
- It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.
- A 2020 review on the role of d-panthenol on wound healing states that it is excellent for post-procedural wounds, especially when used immediately after skin damage.
Boosts skin barrier function:
- Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
Source - A 2016 study also found that d-panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration. It also retains or increases molecular fluidity to compensate for reduced hydration.
Source
Soothes and reduces inflammation:
- Panthenol’s moisturising properties also contribute to its anti-inflammatory nature.
- Keeping the skin moisturised can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
- A 2019 study adds that panthenol may alleviate facial redness resulting from winter xerosis in people with sensitive skin.
Source
Medilan™ is Super Refined and highly purified lanolin, clinically proven to reduce the signs and symptoms of very dry, cracked skin.
Medilan™ has clinically proven safety and efficacy, designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema and psoriasis.
Medilan™'s exceptional purity surpasses that of monograph compliance and has excellent performance in clinical trials.
Being rich in cholesterol and other sterols, lanolin imparts emollient and moisturising properties similar to natural skin lipids.
Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications.
Lanolin efficacy as a medical material and acceptance in Pharmaceutical Industry is reflected in the fact that all major Pharmacopoeia contain monographs for lanolin.
Replenishing essential lipids:
- Medilan™ supplement the skin with the lipids essential to skin health.
- Medilan™ imitate and augment many of the skin's natural lipids due to its chemical and physical similarity.
Repairing the skin’s natural barrier:
- Medilan™ is effective in accelerating the repair of the skin’s natural barrier function.
Protecting against microbial infection:
Medilan is proven to control a variety of microorganisms.
- Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
- Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
- Pseudomonas aeruginosa is a gram negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.
Medilan summary:
- Medilan imitates many of the functions of human skin lipids.
- Medilan is nearly twice as effective as the physiological lipids in human skin.
- In clinical trials, Medilan maintain skin hydration for up to 2 days after application.
- In clinical trials, Medilan increased the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment.
- Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.

WHICH DERMEXCEL™ MOISTURISER SHOULD I USE?

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"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" .
Dr. Y Lamberts
"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."
Dr. C Giezing
"I see impressive results with DermExcel in my practice. My patients are amazed by the results".
Dr. N Msizi

DERMEXCEL™
Medical-grade skin care products formulated according to pharmaceutical standards of purity, potency, and stability. All active ingredients, and the concentrations and dosing protocols in which they are used, are supported by data published in the peer-reviewed medical literature.
DermExcel™ takes an easy, effective and affordable approach to evaluating and treating the skin. Targeted treatments to improve skin conditions and maintain skin health.