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irritated skin
aging
Dry skin
Inflammation
Allergies
A cutting-edge product formulated to restore the skin barrier function on a physiological level. With its Triple Physiological Lipid-based Technology, this ultra-advanced formula combines various moisturizing agents to create an intelligent moisturizing complex.
It contains patented intelligent hydration technology that operates through a dual mechanism to optimize skin moisturization. Firstly, it forms an intelligent structural layer on the skin's surface, providing immediate hydration and sealing in moisture. Secondly, it regulates water loss from within by reinforcing the skin's natural barrier, preventing excessive moisture evaporation.
Enriched™ is particularly effective for individuals with very dry skin conditions such as eczema, dermatitis, psoriasis, and ichthyosis. By replenishing the skin's essential lipids and lamellar bilayers, this intensely moisturizing complex promotes optimal recovery for dry skin and aids in repairing impaired barrier function.
The results of using Enriched™ are remarkable. Your skin will experience a newfound smoothness with deep hydration that lasts. Moreover, your skin’s resilience will improve, allowing it to withstand external aggressors better and maintain optimal health.
Ceramides
Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.
Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.
The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.
Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.
Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.
Physiological Effects
- Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
- Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
- Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
- Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
- Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.
Managing Dermatological Conditions
- Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
- Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
- Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
- Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
- Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.
References
- Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
- Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
- Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
d-Panthenol
d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.
d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:
Physiological Effects
- Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
- Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
- Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
- Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
- Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.
Managing Dermatological Conditions
- Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
- Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
- Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
- Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.
References
- Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
- Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
- Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.
Essential Fatty Acids
Essential Fatty Acids: Nourishing Your Skin from Within
In the realm of dermatological science, essential fatty acids (EFAs) have emerged as unsung heroes, offering a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin.
Pharmacological Advantages
EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.
Physiological Harmony
EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.
Biochemical Brilliance
Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.
References
- Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
- Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
- Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
- Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
- Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
- Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.
Hyaluronic acid
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective, epithelial, and neural tissues. Most abundantly present in the skin, eyes, and synovial fluid, HA is renowned for its exceptional capacity to retain moisture — a single gram can hold up to six liters of water.
In skincare, the primary appeal of hyaluronic acid lies in its unparalleled hydrating abilities. As a humectant, HA attracts and retains moisture from the environment, providing intense hydration to the skin. This hydrating property contributes significantly to maintaining skin plumpness, suppleness, and elasticity.
Beyond hydration, hyaluronic acid also plays a vital role in skin repair and regeneration. It supports the skin's healing and repair processes, and its anti-inflammatory properties help calm irritated skin. Moreover, HA's ability to promote collagen production, a crucial protein for skin elasticity, further underscores its anti-aging benefits.
The molecular size of hyaluronic acid influences its skin penetration and efficacy. High-molecular-weight HA remains on the skin's surface, providing hydration and forming a barrier against moisture loss. In contrast, low-molecular-weight HA penetrates deeper into the skin's layers, offering more profound hydrating and rejuvenating effects.
Hyaluronic acid's remarkable ability to hydrate, improve skin elasticity, aid in wound healing, and provide antioxidant protection makes it valuable in managing various dermatological conditions, particularly aging, dryness, and sensitive skin.
Physiological Effects
- Hydration: Hyaluronic acid is a powerful humectant that can hold up to 1000 times its weight in water, significantly enhancing skin hydration and leading to plumper, more hydrated skin.
- Skin Elasticity and Wrinkle Reduction: By increasing skin moisture, it improves skin elasticity, reduces the appearance of fine lines and wrinkles, and gives the skin a more youthful appearance.
- Wound Healing: It plays a role in wound healing due to its ability to regulate inflammation levels and signal the body to build more blood vessels in the damaged area.
- Barrier Enhancement: Hyaluronic acid helps reinforce the skin's natural barriers, protecting against environmental factors and retaining moisture.
- Antioxidant Properties: It provides antioxidant defense against free-radical damage from the sun and pollution.
Managing Dermatological Conditions
- Aging Skin: Its ability to reduce wrinkles and improve skin elasticity makes it popular in anti-aging skincare products.
- Dry Skin: Hyaluronic acid is beneficial in treating dry skin conditions by providing intense hydration.
- Wound Care: Its role in wound healing is leveraged in post-procedure care, such as after laser treatments, and in healing minor cuts and abrasions.
- Acne Scars: It can help treat acne scars by promoting skin regeneration and reducing inflammation.
- Sensitive Skin: Hyaluronic acid is suitable for sensitive skin due to its gentle nature. It provides hydration without irritating.
References
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology.
- Jegasothy, S. M., Zabolotniaia, V., & Bielfeldt, S. (2014). Efficacy of a new topical nano-hyaluronic acid in humans. The Journal of Clinical and Aesthetic Dermatology.
- Wollina, U., & Abdel-Naser, M. B. (2019). Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology.
SHIPPING
- Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
- Where We Ship From: Orders are dispatched from our facilities in Pretoria.
- Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
- When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
- Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.
For any shipping inquiries, our customer service team is ready to assist.
RETURNS
Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.
If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.
Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.
Feel as confident in us as we want you to feel in your skin.
SECURE PAYMENT
Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee.
If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.
Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.
Feel as confident in us as we want you to feel in your skin.
Choose options
- Eczema: Help alleviate the symptoms of eczema, including itching, redness, inflammation, and dry patches.
- Dry Skin (Xerosis): Provides intense hydration to address the symptoms of dry skin, such as tightness, roughness, and flakiness.
- Dermatitis: Beneficial for various types of dermatitis, such as contact dermatitis, atopic dermatitis, and seborrheic dermatitis. It helps soothe irritated skin and supports the healing process.
- Psoriasis: Aids in the management of psoriasis by moisturizing the skin, reducing redness, and supporting the skin's natural barrier function.
- Ichthyosis: Effective in addressing the scaling, roughness, and excessive dryness associated with ichthyosis, a genetic disorder that impairs the skin's ability to retain moisture.
- Impaired barrier function: The product aids in restoring the physiological barrier function of the skin, which can be compromised due to various factors such as aging, environmental stressors, or certain skin conditions.
- Application time: Morning and/or Evening.
- Frequency: Use once or twice daily, depending on the severity of skin dryness or sensitivity, or use according to your dermal Diagnosis treatment instructions.
- Start with clean and dry skin.
- Use your DermExcel cleanser to remove dirt and excess oil from your skin.
- Dispense moisturizer onto your fingertips. Smooth the product evenly over your face. Ensure you cover all dry or sensitive areas.
- Using your fingertips, gently massage the product into your skin in a circular motion until fully absorbed.
- Apply your moisturizer to damp skin. Moisturizers are most effective if you use them while your skin is damp because damp skin absorbs the product more readily. That also gives the moisturizer a chance to lock in that hydration.
Active ingredients
- Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
- Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
- Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
- Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
- Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.
- Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
- Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
- Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
- Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
- Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.
- Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
- Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
- Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
- Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
- Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
- Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
- Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
- Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.
- Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
- Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
- Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
- Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.
- Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
- Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
- Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.
- Elias, P. M. et al. (2008). Skin diseases associated with decreased epidermal lipogenesis. Annals of the New York Academy of Sciences, 1141(1), 1-13.
- Ziboh, V. A. et al. (2000). Biochemical basis of the essential fatty acid requirement for normative growth in neonatal baboons. American Journal of Clinical Nutrition, 71(1), 3-11.
- Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92-101.
- Levesque, A. et al. (2018). Omega-3 fatty acids: Anti-inflammatory and skin barrier benefits. Omega-3 Fatty Acids: Keys to Nutritional Health, 303-315.
- Nicolaou, A. (2013). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 88(1), 131-138.
- Meydani, S. N. et al. (2018). Nutrition interventions in aging and age-associated diseases. Annals of the New York Academy of Sciences, 1418(1), 34-51.
- Hydration: Hyaluronic acid is a powerful humectant that can hold up to 1000 times its weight in water, significantly enhancing skin hydration and leading to plumper, more hydrated skin.
- Skin Elasticity and Wrinkle Reduction: By increasing skin moisture, it improves skin elasticity, reduces the appearance of fine lines and wrinkles, and gives the skin a more youthful appearance.
- Wound Healing: It plays a role in wound healing due to its ability to regulate inflammation levels and signal the body to build more blood vessels in the damaged area.
- Barrier Enhancement: Hyaluronic acid helps reinforce the skin's natural barriers, protecting against environmental factors and retaining moisture.
- Antioxidant Properties: It provides antioxidant defense against free-radical damage from the sun and pollution.
- Aging Skin: Its ability to reduce wrinkles and improve skin elasticity makes it popular in anti-aging skincare products.
- Dry Skin: Hyaluronic acid is beneficial in treating dry skin conditions by providing intense hydration.
- Wound Care: Its role in wound healing is leveraged in post-procedure care, such as after laser treatments, and in healing minor cuts and abrasions.
- Acne Scars: It can help treat acne scars by promoting skin regeneration and reducing inflammation.
- Sensitive Skin: Hyaluronic acid is suitable for sensitive skin due to its gentle nature. It provides hydration without irritating.
- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology.
- Jegasothy, S. M., Zabolotniaia, V., & Bielfeldt, S. (2014). Efficacy of a new topical nano-hyaluronic acid in humans. The Journal of Clinical and Aesthetic Dermatology.
- Wollina, U., & Abdel-Naser, M. B. (2019). Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects. Skin Pharmacology and Physiology.
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
Ceramides
Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.
Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.
The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.
Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.
Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.
Physiological Effects
Managing Dermatological Conditions
References
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
Managing Dermatological Conditions
References
d-Panthenol
d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.
d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:
Physiological Effects
Managing Dermatological Conditions
References
Essential Fatty Acids
Essential Fatty Acids: Nourishing Your Skin from Within
In the realm of dermatological science, essential fatty acids (EFAs) have emerged as unsung heroes, offering a multifaceted approach to improving skin health in patients with conditions such as eczema and dry skin.
Pharmacological Advantages
EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.
Physiological Harmony
EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.
Biochemical Brilliance
Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier acts as a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.
References
Hyaluronic acid
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the body's connective, epithelial, and neural tissues. Most abundantly present in the skin, eyes, and synovial fluid, HA is renowned for its exceptional capacity to retain moisture — a single gram can hold up to six liters of water.
In skincare, the primary appeal of hyaluronic acid lies in its unparalleled hydrating abilities. As a humectant, HA attracts and retains moisture from the environment, providing intense hydration to the skin. This hydrating property contributes significantly to maintaining skin plumpness, suppleness, and elasticity.
Beyond hydration, hyaluronic acid also plays a vital role in skin repair and regeneration. It supports the skin's healing and repair processes, and its anti-inflammatory properties help calm irritated skin. Moreover, HA's ability to promote collagen production, a crucial protein for skin elasticity, further underscores its anti-aging benefits.
The molecular size of hyaluronic acid influences its skin penetration and efficacy. High-molecular-weight HA remains on the skin's surface, providing hydration and forming a barrier against moisture loss. In contrast, low-molecular-weight HA penetrates deeper into the skin's layers, offering more profound hydrating and rejuvenating effects.
Hyaluronic acid's remarkable ability to hydrate, improve skin elasticity, aid in wound healing, and provide antioxidant protection makes it valuable in managing various dermatological conditions, particularly aging, dryness, and sensitive skin.
Physiological Effects
Managing Dermatological Conditions
References
Medilan™
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Physiological Effects
Managing Dermatological Conditions
References
Full Ingredient list
Aqua, white soft paraffin, extra pure lanolin, emulsifying wax, glycerin, stearic acid, ceramides, cholesterol, liquid paraffin, niacinamide, cetyl alcohol, cetomacrogol, isostearyl isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, ethyl hexyl glycerin, phenoxyethanol, carbomer, d-panthenol, sodium hyaluronate, C12-17 alkane, triethanolamine.
Enriched
product benefits
Intense hydration
Shield the skin from external irritants and pollutants by forming a protective barrier, providing continuous hydration, improving skin elasticity, and supporting the skin's natural defense mechanisms.
Itch Relief
It provides relief from itching and discomfort by reducing inflammation. By reducing scratching, it prevents further skin damage and potential infections.
Promote Cell Renewal
It enhances skin regeneration by optimizing cellular processes and stimulating the production of new skin cells which helps to rejuvenate the skin, diminish signs of aging, and enhance skin vitality.
Barrier Repair
Physiological barrier repair by strengthening the skin's structural integrity, reducing sensitivity and increasing the skin's ability to defend against harmful agents
Indications for Enriched
Aging Skin
Dry and Tight Skin
Ichthyosis
Volume loss
enriched
mode of action
Niacinamide
INHIBIT HYPERPIGMENTATION
- Prevents DNA damage through antioxidant activity.
- Prevent melanosome transfer from melanocytes to surrounding skin cells.
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TREATING ROSACEA, ACNE AND OTHER INFLAMMATORY SKIN CONDITIONS
- Reduce the inflammatory response by inhibiting inflammatory messengers.
- Provides long-lasting protection against bacteria through activation of anti-microbial peptides
- Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.
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TREATING AND PREVENTING PREMATURE SKIN AGING
- Stimulate collagen synthesis and significantly increase skin elasticity.
- Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
- Prevents DNA damage through antioxidant activity.
- Increases production of ceramides and other stratum corneum lipids to improve skin barrier function.
- Niacinamide boosts cellular energy and may enhance energy-dependent cellular processes such as DNA repair.
Hyaluronic acid
- Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body, including wound repair, cell migration, and cell signalling.
- With age, hyaluronic acid in the skin decreases sharply, resulting in a loss of hydration, volume and plumpness. Lines and wrinkles also appear, leaving skin looking dull and lacklustre.
- Hyaluronic acid comes in various molecular sizes. Larger molecules stay on the surface and give the skin a ‘dewy’ look, while smaller molecules penetrate deeper into the skin to deliver their hydration and plumping benefits.
- The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
- The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
- High molecular weight: Doesn't penetrate the epidermis.
Very low molecular weight: Penetrate the skin efficiently but can induce a pro-inflammatory response.
Low molecular weight HA [50 kDa]: Penetrates into the skin well and does not cause inflammation.
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HYDRATION
- Hyaluronic acid can bind water up to 1000 times its volume and contributes to cellular growth, adhesion, and membrane receptor function.
- Hyaluronic acid reinforces the intercellular structures and produces the elastoviscous fluid matrix that firmly envelops collagen and elastin fibres.
- Hyaluronic acid holds moisture and provides firmness and radiance to the skin.
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ANTI-AGING
- Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
- Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes.
- Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
- In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
- Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity.
Medilan™
KEY BENEFITS
Medilan imitates many functions of human skin lipids, which is nearly twice as effective as the physiological lipids in human skin.
Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.
In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment.
Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.
Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.
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REPLENISHING ESSENTIAL LIPIDS
Medilan™ supplements the skin with the lipids essential to skin health.
Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.
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REPAIRING THE SKIN’S NATURAL BARRIER
Medilan™ effectively accelerates the repair of the skin’s natural barrier function.
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PROTECTING AGAINST MICROBIAL INFECTION
Medilan is proven to control a variety of microorganisms.
- Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
- Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
- Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.
d-Panthenol
D-Panthenol stimulates the proliferation of dermal fibroblasts and can accelerate cell turnover.
WOUND HEALING
- D-Panthenol is used in medical wound-healing formulations to help treat skin injuries, burns, and sunburn.
- It's also beneficial after medical and cosmetic surgeries for its wound-healing properties.
- It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.
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REPAIR SKIN BARRIER FUNCTION
- D-Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
- D-Panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration.
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ANTI-INFLAMMATORY
- Panthenol’s moisturizing properties also contribute to its anti-inflammatory nature.
- Keeping the skin moisturized can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
- Studies indicate that D-Panthenol may alleviate facial redness from winter xerosis in people with sensitive skin.
Glycerin
- Humectant. It allows the skin to retain moisture. It increases skin hydration, relieves dryness, and refreshes the skin’s surface.
- Emollient. Soften rough or dry patches on the skin.
- Anti-microbial. It helps to protect the skin from harmful microorganisms.
Fatty acids
Essential fatty acids (EFAs) offer a multifaceted approach to improving skin health in patients with eczema and dry skin conditions.
BIOCHEMICAL BRILLIANCE
Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier is a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.
PHARMACOLOGICAL ADVANTAGES
EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.
PHYSIOLOGICAL HARMONY
EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.
lipid bilayer technology
barrier function & repair
the skin barrier's two primary functions
When one or both of these barrier functions are impaired, the result is DRY SKIN
Permeability Barrier
It creates a barrier against electrolytes and moisture loss (TEWL—trans-epidermal Water loss), protecting the skin from becoming dry.
Anti-microbial Barrier
It creates a barrier against the entry of unwanted microorganisms, such as allergens and irritants. This function protects the skin against irritant dermatitis and skin infections.
line
treatment objectives
barrier impairment
Physiological barrier repair with lipid-based, ceramide-dominant therapy.
Increase the moisture content of the epidermis with Humectants.
Increase cellular turnover by hydrating skin with Emollients.
Create a protective layer on top of the skin to prevent water loss and “seal” in moisture with occlusives.
Relieve skin itching skin by increasing the skin's natural moisturizing factor.
Fill the gaps between skin cells and replace missing lipids in the skin barrier with Emollients.
Testimonials
I love the softness of this product.
I can absolutely see how my rocasea calms and settle when I use DermRepair. I also don't have dryness and flaking of my skin. I use it daily in the morning and evening.
Just what I needed for my oily skin
I love Dermal Health products 🤩 my skin has always been problematic after giving birth along with sensitivity but after using these products its been noticeable pleasant 🤍
Amazing moisturiser, love how hydrated it makes my skin feel 🙏🏻
So glad I came back for a second round after my 1st purchase. Best products since sliced bread. I’ve recommended the products to a friend over the festive season and they will never use something else again.
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