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- Aging skin and sun-damaged skin
- Pigmentation
- Dry and dehydrated skin
- Dull and lifeless skin
- Acne/breakouts and congested pores
- Rosacea prone / red skin
ACTIVE INGREDIENTS:
- Retinoic acid analogue: 3%
- Niacinamide: 4%
- Zinc PCA: 1%
- Powerful peptide complex: 10%
Matrixyl® Synthe'6 and Argireline®
ANTIOXIDANTS & ANTI-INFLAMMATORIES:
- Retinoic acid analogue: 3%
- Niacinamide: 4%
- Zinc PCA: 1%
SEBUM-REGULATOR:
- Zinc PCA: 1%
Tyrosinase gene transcription inhibitor:
- Retinoic acid analogue: 3%
TYROSINASE INHIBITOR:
- Retinoic acid analogue: 3%
DERMAL MATRIX STIMULATOR:
- Niacinamide: 4%
- Retinoic acid analogue: 3%
- Powerful peptide complex: 10%Matrixyl® Synthe'6 and Argireline®
MELANOSOME TRANSFER INHIBITOR:
- Niacinamide: 4%
FULL INGREDIENT LIST:
Aqua, Niacinamide, Acetyl Hexapeptide-8 & Caprylyl Glycol, Dimethyl Isosorbide & Hydroxypinacolone Retinoate, Glycerin, Hydroxypropyl Cyclodextrin & Palmitoyl Tripeptide-38, Sodium Acrylates Copolymer & Lecithin, Phenoxyethanol & Ethylhexylglycerin, Acrylates copolymer, Glycerin, C14-22 Alkane, Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate
TIME AND FREQUENCY OF APPLICATION:
- Use morning and/or evening or follow your Dermal Diagnosis treatment plan directions.
FOLLOW THESE DIRECTIONS TO GET THE MOST OUT OF YOUR SERUM:
- CLEANSE
- Apply Retinol serum to damp skin
- LESS IS MORE
The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
Moist skin is more permeable than dry skin, so apply serum to damp skin after cleansing for quick, deep absorption. Press serum into the skin with an open palm instead of fingertips to release active ingredients.
Serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.
ACTIVE INGREDIENTS IN DERMEXCEL™ RETINOL SERUM
DermExcel Retinol serum contains 3% GranActive Retinoid - Hydroxypinacolone Retinoate (HPR).
Inside our skin, we have retinol receptors called retinoic acid receptors (RAR) and retinoid X receptors (RXR). Retinol acts on those receptors to speed up skin cell production. Retinol also encourages collagen production, so, essentially, it triggers your skin to act younger. Old cells die faster, making way for new, young, healthy cells.
AGING
- Prevention: Retinol focuses on preventing wrinkle or aging formation on a cellular level by preventing the degradation of collagen and elastin.
- Correction: Retinol and Niacinamide stimulate the production of collagen. This formula will also reduce inflammation, which significantly degrades collagen and elastin within the skin.
PIGMENTATION
- Tyrosinase inhibitor: Retinol inhibits the enzymes responsible for pigmentation.
- Melanosome transfer inhibitor: DermExcel Retinol serum also includes Niacinamide, inhibiting pigment transfer to skin cells.
- Keratolytic: Retinol will also accelerate the cell turnover to such an extent that it outpaces melanin production.
ACNE
- Retinol improves and corrects the DNA communication between the cells to prevent the cells from clumping and sticking together.
- Retinol will also reduce the production of sebum and will assist in increasing exfoliation and unclogging of pores.
- Retinol will reduce inflammation that contributes to the formation of acne.
Inhibit hyperpigmentation:
- Prevents DNA damage through antioxidant activity.
- Prevent melanosome transfer from melanocytes to surrounding skin cells.
Treating Rosacea, Acne and other inflammatory skin conditions:
- Reduce the inflammatory response by inhibiting inflammatory messengers.
- Provides long-lasting protection against bacteria through activation of anti-microbial peptides
- Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.
Treating and preventing premature skin aging:
- Stimulate collagen synthesis and significantly increase skin elasticity.
- Prevents the breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
- Prevents DNA damage through antioxidant activity.
Argireline® peptide solution C is the first anti-wrinkle hexapeptide with a Botulinum Toxin-like mechanism of action. It reduces the depth of the facial wrinkles caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.
This hexapeptide relaxes the muscles responsible for the formation of expression lines.
The release of neurotransmitters is impaired, resulting in weakened facial contractions, thus inhibiting the formation of wrinkles.
- Matrixyl® Synthe'6 is a powerful lipopeptide that stimulates the synthesis of six major cell-building components that are natural ingredients in the skin’s matrix.
- This peptide helps to rebuild several types of collagen found in the skin that are especially beneficial, along with fibronectin and hyaluronic acid.
- Matrixyl® Synthe'6 assists in restoring collagen and elastin, while strengthening the skin’s matrix including:
- Matrixyl® Synthe'6 assists in restoring collagen and elastin, while strengthening the skin’s matrix including:
- Smoothing out the appearance of pronounced wrinkles
- Increasing firmness of skin
- Improving photo damaged skin
- Improving overall texture
INDICATIONS FOR DERMEXCEL™ RETINOL SERUM
- Aging and sun-damaged skin
- Pigmentation
- Dry and dehydrated skin
- Dull and lifeless skin
- Acne/breakouts and congested pores
- Rosacea / red skin
DERMEXCEL™ AGING TREATMENT STRATEGY
RESURFACE
Glycolic gel; Renewal Facial cleanser
Remove the damaged epidermis to be replaced with remodelled skin layers.
Resurfacing procedures can induce the formation of new collagen with a more structured pattern.
PREVENT
Collagen serum, Retinol serum, Dermdefence SPF 50
Stop and prevent collagen destruction with Retinoids, Vitamin C, Vitamin E, and Sunscreen.
Vitamin C and Vitamin E are antioxidants that inhibit the activity of free radicals and MMPs (enzymes that cause collagen and elastin destruction).
The activity of MMP's can be stopped in two ways:
- Prevent their formation with sunscreen - Dermdefence SPF 50
- Stop their destructive activity with the MMP inhibitors Retinoids and antioxidants Vitamin C and Vitamin E
RESTORE
Collagen serum
Restore the skin structure support and hydration with Hyaluronic acid.
Hyaluronic acid enhances the skin's ability to attract and retain water deep within its surface for intense, long-lasting hydration. It hydrates, supports and provides structure to Collagen & Elastin, leading to a more plumped complexion.
STIMULATE
Retinol serum
Stimulate collagen production and formation with Retinoids.
DIFFERENT RETINOID MOLECULES
DERMEXCEL™ Retinol serum contains 3% GranActive Retinoid - Hydroxypinacolone Retinoate (HPR).
- Inside our skin, we have retinol receptors called retinoic acid receptors (RAR) and retinoid X receptors (RXR). When you apply prescription retinol, known as retin-A or retinoic acid, the retinol acts on those receptors to speed up skin cell production.
Retinol also encourages collagen production so, essentially, it triggers your skin to act younger. Old cells die faster, making way for new, young, healthy cells.
Over-the-counter retinol has to go through a conversion process once inside the skin before it can act on the receptors, which means it is less likely to irritate than stronger prescription retinol.
- Retinoic Acid (also known as retin-A or tretinoin) is very potent and only available with a prescription.
Conversion: No conversion is needed, as it is already in the active form. It binds directly to the retinoid receptors to activate a biological response.
Efficacy: Highly effective as it binds directly to the retinoid receptors and activates a biological response. It acts immediately on receptors for fast and furious results.
Side Effects: Depending on the percentage, it can cause severe and very uncomfortable side effects, including redness and peeling - even if you don't have sensitive skin.
- DERMEXCEL™ Retinol serum contains 3% GranActive Retinoid - Hydroxypinacolone Retinoate (HPR).
This molecule is an ester of the prescription retinoic acid and the hottest new retinol on the block. It is unique in that it processes innate retinoic acid activity, and thus does not need to undergo metabolic breakdown to achieve skin benefits. It has been demonstrated to be more stable and cause less skin irritation than Retinoic acid, or any other less effective form of Vitamin A.
Conversion: It works directly on receptors in the skin just like retinoid acid, but has little-to-no downtime making it an ideal choice for anyone who does not want to risk irritation and wants quick results.
Efficacy: Highly effective as it binds directly to the retinoid receptors and activates a biological response. It acts immediately on receptors for fast and furious results.
Side Effects: No side effects, as it does not bind to the specific receptor that causes the side effects.
- An OTC vitamin A derivate that we have all heard of.
Conversion: Once applied, it sinks into the skin where it is converted to retinaldehyde and then to retinoic acid.
Efficacy: Potency and efficacy depend on product formulation, pH, and Retinol concentration. This Retinol molecule needs to be converted to the active form (all-trans retinoic acid) before it can bind to the retinoid receptors to activate a biological response - all dermatological benefits. Because of this conversion, studies indicate that 1% Retinol is about 20 times weaker than the active form of Retinoic acid. 1% Retinol, equivalent to about 0.05% Retinoic acid.
Side Effects: Depending on the percentage it can cause some redness and peeling if your skin is slightly sensitive. The best way to avoid side effects is to use it two nights a week, see how your skin reacts and once it becomes more accustomed to the retinol ingredient, gradually work your way up to three nights and then four.
- An OTC vitamin A derivative proven in clinical studies to be the least effective form of Retinol.
Conversion: Retinyl palmitate does not penetrate the skin very well. Once applied, it needs to undergo significant complex conversions before it can bind to RA receptors to yield a biological response.
Efficacy: There is no significant evidence in the literature to support the effectiveness of topical retinyl-palmitate as an antiaging agent.
Side Effects: Because of the low efficacy profile there is little to no risk for side effects.
TREATMENT PACKS CONTAINING LITADERM SERUM
PIGMENTATION TREATMENT PACKS
ROSACEA TREATMENT PACKS
ACNE TREATMENT PACKS
"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" .
Dr. Y Lamberts
"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."
Dr. C Giezing
"I see impressive results with DermExcel in my practice. My patients are amazed by the results".
Dr. N Msizi
REVIEWS ON DERMEXCEL™ TREATMENT SERUMS
Yes - Even though no evidence suggests that the molecule in our Retinol serum should be avoided during pregnancy, this particular active ingredient is an ester of the prescription molecule retinoic acid; therefore, our ethical and legal obligation is to be overly cautious.
Discuss the use of topical Retinol usage during pregnancy with your gynaecologist. They will be the best source of information regarding the safety risks.
As soon as you find out you are pregnant. We only advise you to stop using Retinol serum as a precaution.
Yes, it is safe to use the DermExcel Retinol serum while breastfeeding.
THE EVIDENCE
- Because tretinoin (the prescription molecule, remember, our Retinol is an ester of the prescription molecule) is poorly absorbed after topical application. It is considered a low risk to the nursing infant.
Ref: Drugs and Lactation Database (Lactmed) - Blood concentrations measured 2-48 hours following application are essentially zero. Absorption of Retin-A (Tretinoin) via topical sources is reported to be minimal, and breastmilk would likely be minimal to none.
Ref: Dr. Thomas Hale, Medications and Mother's Milk - Vitamin A and, presumably, tretinoin (all-trans-retinoic acid) are natural constituents of human milk. There are no data on the amount of all-trans retinoic acid excreted into milk after topical use. Although other retinoids are excreted (see Vitamin A), the minimal absorption after topical application of tretinoin probably precludes the detection of clinically significant amounts in breast milk from this source. Thus, the use of tretinoin while breastfeeding does not appear to represent a significant risk to a nursing infant.
Ref: Drugs in Pregnancy and Lactation: Gerald Briggs, pharmacologist at Washington State University College of Pharmacy.
The type of Vitamin A. DERMEXCEL™ Retinol serum contains 3% GranActive Retinoid - Hydroxypinacolone Retinoate (HPR).
The normal retinol molecule needs to be converted to the active form (all-trans retinoic acid) before it can bind to the retinoid receptors to activate a biological response - all dermatological benefits.
Because of this conversion, studies indicate that 1% Retinol is about 20 times weaker than the active form of Retinoic acid. 1% Retinol, equivalent to about 0.05% Retinoic acid. The HPR retinoid molecule needs no conversion to bind to Retinoid receptors as it’s already in the active form. It binds directly to the retinoid receptor without causing irritation.
The normal retinol molecule and the newly advanced HPR retinoid molecule (included in Granactive Retinol) are two totally different molecules and therefore conversion calculation would be almost impossible. It is however save to say that 3% of the Granactive retinoid molecule yields significantly more retinoid receptor binding activity than 1% retinol (the highest percentage retinol in non-prescription products).
DERMEXCEL™
Medical-grade skin care products formulated according to pharmaceutical standards of purity, potency, and stability. All active ingredients, and the concentrations and dosing protocols in which they are used, are supported by data published in the peer-reviewed medical literature.
DermExcel™ takes an easy, effective and affordable approach to evaluating and treating the skin. Targeted treatments to improve skin conditions and maintain skin health.
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