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DermExcel™ | Litaderm Serum Trial Size
Litaderm serum: Trial
Litaderm serum: Trial
Litaderm serum: Trial
Litaderm serum: Trial
DermExcel™ | Litaderm Serum Trial Size
Litaderm serum: Trial
Litaderm serum: Trial
Litaderm serum: Trial
Litaderm serum: Trial

DermExcel™

Litaderm serum: Trial

R 149.57
R 149.57

SIZE: 5 ml

RETAIL PRICE: R 1,020.00

or 3 x monthly payments of R 0.00 with PAYJUSTNOW®

or 4 x fortnightly payments of R 37.39 with PAYFLEX®

or 3 x monthly payments of R 0.00 with PAYJUSTNOW®

or 4 x fortnightly payments of R 37.39 with PAYFLEX®

or 3 x monthly payments of R 0.00 with PAYJUSTNOW®

or 4 x fortnightly payments of R 37.39 with PAYFLEX®

An amplified correction serum powered by multiple outstanding multi-tasking active ingredients, all supported in the peer-reviewed medical literature, to significantly improve and prevent hyperpigmentation, melasma, and redness - making even skin tones possible for everyone.

Litaderm serum also reduces and prevents inflammation that contributes to acne, rosacea, premature aging, and pigmentation.

This dynamic formula is also a targeted treatment for signs of aging and skin damage. Litaderm promotes healthy, radiant, and even-toned skin. 

  • Pigmentation
  • Acne/breakouts and congested pores
  • Aging skin and sun-damaged skin
  • Rosacea prone / red skin
  • Dull and lifeless skin
  • Dry and dehydrated skin

ACTIVE INGREDIENTS:

  • Azelaic acid: 10%
  • Niacinamide: 10%
  • Arbutin: 4%
  • Bakuchiol: 1%

ANTIOXIDANTS & ANTI-INFLAMMATORIES:

  • Azelaic acid: 10%
  • Niacinamide: 10%
  • Bakuchiol: 1%

MELANIN STIMULATING HORMONE INHIBITOR:

  • Arbutin: 4%

Tyrosinase gene transcription inhibitor:

  • Bakuchiol: 1%

TYROSINASE INHIBITOR:

  • Azelaic acid: 10%
  • Arbutin: 4%
  • Bakuchiol: 1%

MELANOSOME MATURATION INHIBITOR:

  • Arbutin: 4%

MELANOSOME TRANSFER INHIBITOR:

  • Niacinamide: 10%

FULL INGREDIENT LIST:

Aqua, Macrogol, Azelaic acid, Nicotinamide, Glycerine, Arbutin, Jojoba Oil, Bakuchiol, Isostearyl Alcohol · Butylene Glycol Cocoate Ethylcellulose, Butylene glycol, Ceteth-20 · Cetyl Alcohol, Glyceryl Stearate, Steareth-20, C12-15 Alkane, Phenylpropanol, Propanediol, Caprylyl Glycol, Tocopherol

TIME OF APPLICATION:

  • Normal, Oily, and Combination skin types: Apply Litaderm at night.
  • Dry skin types: Apply Litaderm in the morning and/or at night.

FREQUENCY OF APPLICATION:

  • Use daily and/or evening or follow your Dermal Diagnosis treatment plan directions.

FOLLOW THESE DIRECTIONS TO GET THE MOST OUT OF YOUR SERUM:

  • CLEANSE
  • The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.

  • Apply Litaderm serum to damp skin
  • Moist skin is more permeable than dry skin, so apply serum to damp skin after cleansing for quick, deep absorption. Press serum into the skin with an open palm instead of fingertips to release active ingredients.

  • LESS IS MORE
  • Serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.

ACTIVE INGREDIENTS IN LITADERM SERUM

Inhibit hyperpigmentation:

  • Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
  • Prevent DNA damage through antioxidant activity.
  • Destroy damaged hyperactive melanocytes.

Treat Rosacea and other inflammatory skin conditions:

  • Inhibit overactive inflammatory response.
  • Bacteriostatic activity to both aerobic and anaerobic bacteria including P-acnes.
  • Anti-keratinizing agent that inhibit skin cells (keratinocytes) from abnormally multiplying.
  • Inhibit over-production of sebum (oil), thus preventing bacterial growth and inflammation.

Treating and preventing premature skin aging:

  • Prevent breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.

Inhibit hyperpigmentation:

  • Prevents DNA damage through antioxidant activity.
  • Prevent melanosome transfer from melanocytes to surrounding skin cells.

Melanosomes are the organelles that contain the pigment melanin.
Melanocytes are the cells that make the pigment melanin.

Treat Rosacea and other inflammatory skin conditions:

  • Reduce the inflammatory response by inhibiting inflammatory messengers.
  • Provides long-lasting protection against bacteria through activation of anti-microbial peptides.
  • Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.

Treating and preventing premature skin aging:

  • Stimulate collagen synthesis and significantly increase skin elasticity.
  • Prevents breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.

Inhibit hyperpigmentation:

  • Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
  • Prevent maturation of melanosomes thus preventing the progress of the pigmentation process.

Melanosomes are the organelles that contain the pigment melanin.
Melanocytes are the cells that make the pigment melanin.

Inhibit hyperpigmentation:

  • Prevent the melanocyte stimulating hormone from initiating the pigmentation process.
  • Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
  • Prevents DNA damage through antioxidant activity.
  • Down-regulate the tyrosinase gene-transcription, thus inhibiting the actions of Tyrosinase (the main enzyme responsible for pigmentation).

Treat Rosacea and other inflammatory skin conditions:

  • Reduce the inflammatory response by inhibiting inflammatory messengers.Anti-keratinizing agent that inhibits skin cells (keratinocytes) from abnormally multiplying.
  • Significant antibacterial activities against Gram positive and negative bacteria.
  • Suppresses pro-inflammatory cytokine expression. It is a potent anti-inflammatory agent able to control leukocytic functions.
  • Reduce sebaceous glands activity, leading to less pore clogging and potentially less oil production.

Treating and preventing premature skin aging:

  • Retinol and Bakuchiol exhibit a similar gene expression profile, especially on certain key anti-ageing genes, which is remarkable.
  • Promotes skin turnover and stimulate collagen production.
  • Significantly improves skintone, radiance and skin brightening.
  • Significantly improves skintone, radiance and skin brightening.

INDICATIONS FOR LITADERM SERUM

  • Acne and congested pores
  • Rosacea
  • Inflammation
  • Shaving bumps, Ingrown hair or Folliculitis
  • Post-Inflammatory erythema (redness)
  • Post-Inflammatory hyperpigmentation
  • Melasma

LITADERM SERUM ACTION ON ALL PIGMENTATION PHASES

KEYWORDS

  • Melanin: Pigment that causes pigmentation
  • Melanocytes: The cells that make the melanin

PROCESS

  • UV rays trigger free radicals and DNA damage. Other factors that activate this process includes inflammation, irritation, and hormones.
  • DNA damage activates the melanocyte stimulating hormone (MSH).
  • MSH activates the melanocyte to turn on the melanin-synthesis process by activating cell signalling and gene expression of melanin production enzymes. The key enzyme in this process is TYROSINASE.

TARGETED TREATMENT

  • Antioxidants prevent free radicals from damaging DNA thus inhibiting the melanin production process.
    Active ingredients: Bakuchiol, Niacinamide, Azelaic acid
  • Prevent the melanocyte stimulating hormone from initiating the pigmentation process.
    Active ingredient: Arbutin

KEYWORDS

  • Tyrosinase: The main enzyme responsible for pigment production
  • Melanosomes: The organelles containing the melanin pigment

PROCESS

  • Tyrosinase activates the production of the pigment MELANIN in the Melanosome.
  • Melanosomes mature in 4 stages. When melanin synthesis is completed and melanosomes is fully matured, melanosomes move towards melanocyte dendrites (projections of the melanocyte cell that look like legs).

TARGETED TREATMENT

  • Prevent Tyrosinase activity thus preventing production of melanin.
    Active ingredients: Azelaic acid, Arbutin, Bakuchiol
  • Prevent maturation of melanosomes thus preventing the progress of the pigmentation process.
    Active ingredients: Arbutin

KEYWORDS

  • Keratinocytes: Skin cells

PROCESS

  • Melanocytes transfer melanosomes with packaged melanin into the surrounding keratinocytes, thus ensuring skin pigmentation.

TARGETED TREATMENT

  • Inhibit the transfer of the pigment melanin to the skin cells, thus preventing pigmentation.
    Active ingredients: Niacinamide

MODE OF ACTION OF LITADERM SERUM ON PIGMENTATION

BLOCK ALPHA Melanocyte Stimulating Hormone

BAKUCHIOL

  • α-MSH is required for the development of pigmentation, by binding to its specific receptor to upregulate the expression of tyrosinase.

Bakuchiol blocks both the melanocyte-stimulating hormone and tyrosinase activation, and therefore inhibit the pigmentation process.

Tyrosinase Inhibitor

AZELAIC ACID & ARBUTIN

  • Tyrosinase is the key enzyme in the first two steps of melanin production.
  • The inhibition of tyrosinase has an important role in preventing melanin accumulation in the skin.

Azelaic acid and Arbutin inhibit the pigmentation process by blocking tyrosinase catalytic activity and functionality.

Melanosome Transfer Inhibitor

NIACINAMIDE

  • Within a complex metabolic system, niacinamide controls the transcription of signalling molecules.

Niacinamide inhibits the transfer of the pigment melanin to the skin cells, and therefore inhibits the pigmentation process. 

Destroy Damaged Melanocytes

AZELAIC ACID

  • Azelaic acid prevents abnormal melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes.
  • It only targets abnormally hyperactive melanocytes with no cytotoxic effect on normal, healthy-functioning melanocytes.

Azelaic prevents hyperpigmentation by inhibiting abnormal functioning melanocytes.

MODE OF ACTION OF LITADERM SERUM ON PIGMENTATION

α-Melanocyte Stimulating Hormone blocker

BAKUCHIOL

α-MSH is required for the development of pigmentation, by binding to its specific receptor to upregulate the expression of tyrosinase.

Bakuchiol blocks both the melanocyte-stimulating hormone and tyrosinase activation, and therefore inhibit the pigmentation process.

Tyrosinase Inhibitor

AZELAIC ACID & ARBUTIN

Tyrosinase is the key enzyme in the first two steps of melanin production. The inhibition of tyrosinase has an important role in order to prevent melanin accumulation in skin.

Azelaic acid and Arbutin inhibit the pigmentation process by blocking tyrosinase catalytic activity and functionality.

Melanosome Transfer Inhibitor

NIACINAMIDE

Within a complex metabolic system, niacinamide controls the transcription of signalling molecules.

Niacinamide inhibits the transfer of the pigment melanin to the skin cells, and therefore inhibits the pigmentation process. 

Destroy Damaged Melanocytes

AZELAIC ACID

Azelaic acid prevents abnormal melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes. It only targets abnormally hyperactive melanocytes with no cytotoxic effect on normal, healthy functioning melanocytes.

Azelaic prevents hyperpigmentation by inhibiting abnormal functioning melanocytes.

ROSACEA STAGES AND TREATMENT OBJECTIVES

A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.

Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

NORMAL SKIN
PHASE 1

Healthy skin with a perfect balance between normal microflora and skin receptors.

The function of the receptors (PPR):
 Detect and bind harmful molecules and activate the immune response. These receptors should not trigger an immune response by binding to normal microflora.

PHASE 1

PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.

PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

PHASE 2
PHASE 3

This inflammatory environment leads to increased leucocyte and cathelicidin expression (anti-microbial peptide), causing certain normal microbes to be eliminated.

With normal flora out of the way, the opportunity arise for the overgrowth of other microbes to fill the space of the eliminated normal flora. The normal microbes' balance gets disturbed.

PHASE 3

Alterations in the micro-flora create a further imbalance that further elevates the inflammation process.

This leads to the worsening of the disease, and symptoms become more severe.

ROSACEA TREATMENT WITH LITADERM SERUM

AZELAIC ACID

Anti-inflammatory: Decrease the inflammation process leading to breakouts, redness and skin damage.
Anti-microbial: Bacteriostatic activity to both aerobic and anaerobic bacteria including P-acnes.
Antioxidant: Prevent DNA damage, and activation of inflammatory enzymes.
Anti-keratinizing: Inhibits skin cells (keratinocytes) from abnormally multiplying.
Sebum(oil) regulator: Inhibits over-production of sebum (oil), thus preventing bacterial growth and inflammation.

NIACINAMIDE

Anti-inflammatory: Reduce the inflammatory response by inhibiting inflammatory messengers.
Anti-microbial: Provides long-lasting protection against bacteria through the activation of an anti-microbial peptide response.
Sebum (oil) regulator: Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.
Antioxidant: Prevent DNA damage, and activation of inflammatory enzymes.

BAKUCHIOL

Anti-inflammatory: Suppresses pro-inflammatory cytokine expression. It is a potent anti-inflammatory agent able to control leukocytic functions.
Anti-bacterial: Significant antibacterial activities against Gram positive and negative bacteria. 
Anti-keratinizing: Inhibits skin cells (keratinocytes) from abnormally multiplying.
Sebum (oil) regulator: Reduce sebaceous glands activity, leading to less pore clogging and potentially less oil production.

REVIEWS ON DERMEXCEL™ TREATMENT SERUMS

Customer Reviews

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L
Lizelle Visser

Inflacin serum

A
Anette Rheeders

Amazing, all your products are just the best skincare range I have ever used. I am a swimming coach and the chemicals in the water really dries out my skin so much. But since using Dermalhealth I can see a huge difference. Thanks so much.

A
Anél Du Plessis
Inflacin serum

I just love everything about this product. My skin has never been so healthy as it is now.

J
Janine De Rouwe
Great product 👌🏻

Very good product, helped with sensitive irritated skin

G
Georgina Mynhardt
Collagen

Love it!

Z
Zanelle Biewenga
Inflacin Serum

Inflacin serum is the best if you are struggling with breakouts/acne. I have been using this serum for over a year now and I do not get breakouts anymore. The difference in my skin since using Dermexcel is amazing. Very happy with the results.

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TREATMENT PACKS CONTAINING LITADERM SERUM

PIGMENTATION TREATMENT PACKS

ROSACEA TREATMENT PACKS

ACNE TREATMENT PACKS

"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" . 

Dr. Y Lamberts

"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."

Dr. C Giezing

"I see impressive results with DermExcel in my practice. My patients are amazed by the results".

Dr. N Msizi

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DERMEXCEL™

Medical-grade skin care products formulated according to pharmaceutical standards of purity, potency, and stability. All active ingredients and the concentrations and dosing protocols in which they are used are supported by data published in the peer-reviewed medical literature.

DermExcel™ takes an easy, effective and affordable approach to evaluating and treating the skin. Targeted treatments to improve skin conditions and maintain skin health.

FREQUENTLY ASKED QUESTIONS

Yes. The topical use of the active ingredients in Litaderm serum is considered safe during pregnancy.
Ref: The American College Of Obstetricians and Gynecologists

Women want to look their best at this important time in their lives, so it's crucial to determine which products and ingredients are safe to use during pregnancy.

Except for the two prescription molecules, hydroquinone (which has a relatively high systemic absorption rate) and tretinoin (for which the evidence is limited and controversial), skincare products act locally and produce minimal systemic levels. In most cases, women can deal with these cosmetically unappealing skin conditions without compromising the safety of their unborn children.

No DermExcel™ product contains hydroquinone or tretinoin. These active ingredients are only available by prescription from a medical doctor.

DermExcel™ Retinol serum contains an active ingredient very similar to tretinoin. We, therefore, advise customers to discontinue the use of Retinol serum until after pregnancy.

For more information regarding the use of DermExcel™ products during pregnancy - please consult with your medical practitioner.

Litaderm serum can be paired with any other DermExcel treatment serum.

Morning: Alternate Litaderm serum with Collagen serum or apply Litaderm after Collagen serum.

Evening: Alternate Litaderm serum with Retinol serum, or use both serums on the same night, in any order you prefer.

Inflacin serum can be applied in the morning and/or evening. 

Normal reactions may include stinging or burning, skin peeling, or skin irritation.

Follow the below guidelines to manage the initial irritation reaction:

  • Contra-indications of Inflacin serum: Patients with a known allergy to any of the ingredients in Acne Repair serum should not use it. 
  • Acne patients: Inflacin serum has many benefits and proven efficacy for treating acne.
  • Sensitive skin: For sensitive skin or skin not used to active ingredients, start Inflacin serum every other day. Initial sensitivity reactions may occur.
  • Resistant skin can use Inflacin serum morning and / or night as tolerated.

Medical skincare products are more focused on the formulation of advanced serums rather than moisturisers for the following reason:

Moisturisers are primarily designed to hydrate the skin by adding to- and sealing in the natural moisture of the body.
Although moisturisers often contain ingredients to target specific issues like aging or sun damage, their main role is to get hydration to the skin and keep it there.

Serums, on the other hand, are formulated to penetrate deeply into the skin and address or even reverse the causes of aging and skin damage at the cellular level.
Serums contain more active ingredients, antioxidants, nutrients, and vitamins that work to repair the structure of skin cells, increasing skin radiance, smoothness, and suppleness.

Dermal Health Science™ products are formulated and manufactured in a facility regulated by the South African Pharmacy Council (SAPC), the regulator established in terms of the Pharmacy Act, 1974 (Act 53 of 1974).

All product formulations are free from any known or common allergens.

DermExcel products are:

- Fragrance-free
- Paraben-free
- Non-comedogenic
- pH-optimized
- Clinically tested

Click here to learn more about Dermal Health Science™

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So far I am enjoying the products. I would like something a bit more moisturizing, but I am excited to see the results. I do get lots of compliments on my skin!

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Michelle Ellis

Absolutely in love with my pore control cleanser

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Jade Turner
Great product

I’ve been using the dermexel for a couple of weeks and it works wonderfully with my skin

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Stephanie Botha
Love the Black Lip Butter Tube

Awesome packaging!! Excellent product - always in my shopping cart when purchasing.

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Telicia Annandale
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Lovely product. You see instant results. I use it for dry places in the face for the whole family. Works so great.

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Candice George
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Noticed the difference within a week, im definitely trying the collagen and retinol.

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