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- Pigmentation
- Acne/breakouts and congested pores
- Aging skin and sun-damaged skin
- Rosacea prone / red skin
- Dull and lifeless skin
- Dry and dehydrated skin
ACTIVE INGREDIENTS:
- Azelaic acid: 10%
- Niacinamide: 10%
- Arbutin: 4%
- Bakuchiol: 1%
ANTIOXIDANTS & ANTI-INFLAMMATORIES:
- Azelaic acid: 10%
- Niacinamide: 10%
- Bakuchiol: 1%
MELANIN STIMULATING HORMONE INHIBITOR:
- Arbutin: 4%
Tyrosinase gene transcription inhibitor:
- Bakuchiol: 1%
TYROSINASE INHIBITOR:
- Azelaic acid: 10%
- Arbutin: 4%
- Bakuchiol: 1%
MELANOSOME MATURATION INHIBITOR:
- Arbutin: 4%
MELANOSOME TRANSFER INHIBITOR:
- Niacinamide: 10%
FULL INGREDIENT LIST:
Aqua, Macrogol, Azelaic acid, Nicotinamide, Glycerine, Arbutin, Jojoba Oil, Bakuchiol, Isostearyl Alcohol · Butylene Glycol Cocoate Ethylcellulose, Butylene glycol, Ceteth-20 · Cetyl Alcohol, Glyceryl Stearate, Steareth-20, C12-15 Alkane, Phenylpropanol, Propanediol, Caprylyl Glycol, Tocopherol
TIME OF APPLICATION:
- Normal, Oily, and Combination skin types: Apply Litaderm at night.
- Dry skin types: Apply Litaderm in the morning and/or at night.
FREQUENCY OF APPLICATION:
- Use daily and/or evening or follow your Dermal Diagnosis treatment plan directions.
FOLLOW THESE DIRECTIONS TO GET THE MOST OUT OF YOUR SERUM:
- CLEANSE
- Apply Litaderm serum to damp skin
- LESS IS MORE
The active ingredients in skin serums will stick to dirt and dead skin, so wash your face properly before applying for maximum absorption.
Moist skin is more permeable than dry skin, so apply serum to damp skin after cleansing for quick, deep absorption. Press serum into the skin with an open palm instead of fingertips to release active ingredients.
Serums are super concentrated. Use just 1-2 pumps or a little smaller than a pea-size amount.
ACTIVE INGREDIENTS IN LITADERM SERUM
Inhibit hyperpigmentation:
- Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
- Prevent DNA damage through antioxidant activity.
- Destroy damaged hyperactive melanocytes.
Treat Rosacea and other inflammatory skin conditions:
- Inhibit overactive inflammatory response.
- Bacteriostatic activity to both aerobic and anaerobic bacteria including P-acnes.
- Anti-keratinizing agent that inhibit skin cells (keratinocytes) from abnormally multiplying.
- Inhibit over-production of sebum (oil), thus preventing bacterial growth and inflammation.
Treating and preventing premature skin aging:
- Prevent breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
Inhibit hyperpigmentation:
- Prevents DNA damage through antioxidant activity.
- Prevent melanosome transfer from melanocytes to surrounding skin cells.
Melanosomes are the organelles that contain the pigment melanin.
Melanocytes are the cells that make the pigment melanin.
Treat Rosacea and other inflammatory skin conditions:
- Reduce the inflammatory response by inhibiting inflammatory messengers.
- Provides long-lasting protection against bacteria through activation of anti-microbial peptides.
- Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.
Treating and preventing premature skin aging:
- Stimulate collagen synthesis and significantly increase skin elasticity.
- Prevents breakdown of collagen and elastin through antioxidant and anti-inflammatory activity.
Inhibit hyperpigmentation:
- Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
- Prevent maturation of melanosomes thus preventing the progress of the pigmentation process.
Melanosomes are the organelles that contain the pigment melanin.
Melanocytes are the cells that make the pigment melanin.
Inhibit hyperpigmentation:
- Prevent the melanocyte stimulating hormone from initiating the pigmentation process.
- Stop Tyrosinase activity (enzyme responsible for hyperpigmentation).
- Prevents DNA damage through antioxidant activity.
- Down-regulate the tyrosinase gene-transcription, thus inhibiting the actions of Tyrosinase (the main enzyme responsible for pigmentation).
Treat Rosacea and other inflammatory skin conditions:
- Reduce the inflammatory response by inhibiting inflammatory messengers.Anti-keratinizing agent that inhibits skin cells (keratinocytes) from abnormally multiplying.
- Significant antibacterial activities against Gram positive and negative bacteria.
- Suppresses pro-inflammatory cytokine expression. It is a potent anti-inflammatory agent able to control leukocytic functions.
- Reduce sebaceous glands activity, leading to less pore clogging and potentially less oil production.
Treating and preventing premature skin aging:
- Retinol and Bakuchiol exhibit a similar gene expression profile, especially on certain key anti-ageing genes, which is remarkable.
- Promotes skin turnover and stimulate collagen production.
- Significantly improves skintone, radiance and skin brightening.
- Significantly improves skintone, radiance and skin brightening.
INDICATIONS FOR LITADERM SERUM
- Acne and congested pores
- Rosacea
- Inflammation
- Shaving bumps, Ingrown hair or Folliculitis
- Post-Inflammatory erythema (redness)
- Post-Inflammatory hyperpigmentation
- Melasma
LITADERM SERUM ACTION ON ALL PIGMENTATION PHASES
KEYWORDS
- Melanin: Pigment that causes pigmentation
- Melanocytes: The cells that make the melanin
PROCESS
- UV rays trigger free radicals and DNA damage. Other factors that activate this process includes inflammation, irritation, and hormones.
- DNA damage activates the melanocyte stimulating hormone (MSH).
- MSH activates the melanocyte to turn on the melanin-synthesis process by activating cell signalling and gene expression of melanin production enzymes. The key enzyme in this process is TYROSINASE.
TARGETED TREATMENT
- Antioxidants prevent free radicals from damaging DNA thus inhibiting the melanin production process.
Active ingredients: Bakuchiol, Niacinamide, Azelaic acid - Prevent the melanocyte stimulating hormone from initiating the pigmentation process.
Active ingredient: Arbutin
KEYWORDS
- Tyrosinase: The main enzyme responsible for pigment production
- Melanosomes: The organelles containing the melanin pigment
PROCESS
- Tyrosinase activates the production of the pigment MELANIN in the Melanosome.
- Melanosomes mature in 4 stages. When melanin synthesis is completed and melanosomes is fully matured, melanosomes move towards melanocyte dendrites (projections of the melanocyte cell that look like legs).
TARGETED TREATMENT
- Prevent Tyrosinase activity thus preventing production of melanin.
Active ingredients: Azelaic acid, Arbutin, Bakuchiol - Prevent maturation of melanosomes thus preventing the progress of the pigmentation process.
Active ingredients: Arbutin
KEYWORDS
- Keratinocytes: Skin cells
PROCESS
- Melanocytes transfer melanosomes with packaged melanin into the surrounding keratinocytes, thus ensuring skin pigmentation.
TARGETED TREATMENT
- Inhibit the transfer of the pigment melanin to the skin cells, thus preventing pigmentation.
Active ingredients: Niacinamide
MODE OF ACTION OF LITADERM SERUM ON PIGMENTATION
BLOCK ALPHA Melanocyte Stimulating Hormone
BAKUCHIOL
- α-MSH is required for the development of pigmentation, by binding to its specific receptor to upregulate the expression of tyrosinase.
Bakuchiol blocks both the melanocyte-stimulating hormone and tyrosinase activation, and therefore inhibit the pigmentation process.
Tyrosinase Inhibitor
AZELAIC ACID & ARBUTIN
- Tyrosinase is the key enzyme in the first two steps of melanin production.
- The inhibition of tyrosinase has an important role in preventing melanin accumulation in the skin.
Azelaic acid and Arbutin inhibit the pigmentation process by blocking tyrosinase catalytic activity and functionality.
Melanosome Transfer Inhibitor
NIACINAMIDE
- Within a complex metabolic system, niacinamide controls the transcription of signalling molecules.
Niacinamide inhibits the transfer of the pigment melanin to the skin cells, and therefore inhibits the pigmentation process.
Destroy Damaged Melanocytes
AZELAIC ACID
- Azelaic acid prevents abnormal melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes.
- It only targets abnormally hyperactive melanocytes with no cytotoxic effect on normal, healthy-functioning melanocytes.
Azelaic prevents hyperpigmentation by inhibiting abnormal functioning melanocytes.
α-Melanocyte Stimulating Hormone blocker
BAKUCHIOL
α-MSH is required for the development of pigmentation, by binding to its specific receptor to upregulate the expression of tyrosinase.
Bakuchiol blocks both the melanocyte-stimulating hormone and tyrosinase activation, and therefore inhibit the pigmentation process.Tyrosinase Inhibitor
AZELAIC ACID & ARBUTIN
Tyrosinase is the key enzyme in the first two steps of melanin production. The inhibition of tyrosinase has an important role in order to prevent melanin accumulation in skin.
Azelaic acid and Arbutin inhibit the pigmentation process by blocking tyrosinase catalytic activity and functionality.Melanosome Transfer Inhibitor
NIACINAMIDE
Within a complex metabolic system, niacinamide controls the transcription of signalling molecules.
Niacinamide inhibits the transfer of the pigment melanin to the skin cells, and therefore inhibits the pigmentation process.Destroy Damaged Melanocytes
AZELAIC ACID
Azelaic acid prevents abnormal melanocytes from multiplying by interfering with DNA synthesis and mitochondrial enzymes. It only targets abnormally hyperactive melanocytes with no cytotoxic effect on normal, healthy functioning melanocytes.
Azelaic prevents hyperpigmentation by inhibiting abnormal functioning melanocytes.ROSACEA STAGES AND TREATMENT OBJECTIVES
A constant interplay exists among the skin, micro-organisms, and the environment to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.
In Rosacea, the micro-environment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several micro-organisms have been shown to be increased or immuno-reactive in patients with rosacea.
Or skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin. When they detect these harmful bacteria, they bind to them and activate an immune response.
Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.
Healthy skin with a perfect balance between normal microflora and skin receptors.
The function of the receptors (PPR): Detect and bind harmful molecules and activate the immune response.
These receptors should not trigger an immune response by binding to normal microflora.
PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)
This inflammatory environment leads to increased leucocyte and cathelicidin expression (anti-microbial peptide), causing certain normal microbes to be eliminated.
With normal flora out of the way, the opportunity arise for the overgrowth of other microbes to fill the space of the eliminated normal flora. The normal microbes' balance gets disturbed.
Alterations in the micro-flora create a further imbalance that further elevates the inflammation process.
This leads to the worsening of the disease, and symptoms become more severe.
ROSACEA TREATMENT WITH LITADERM SERUM
AZELAIC ACID
Anti-inflammatory: Decrease the inflammation process leading to breakouts, redness and skin damage.
Anti-microbial: Bacteriostatic activity to both aerobic and anaerobic bacteria including P-acnes.
Antioxidant: Prevent DNA damage, and activation of inflammatory enzymes.
Anti-keratinizing: Inhibits skin cells (keratinocytes) from abnormally multiplying.
Sebum(oil) regulator: Inhibits over-production of sebum (oil), thus preventing bacterial growth and inflammation.
NIACINAMIDE
Anti-inflammatory: Reduce the inflammatory response by inhibiting inflammatory messengers.
Anti-microbial: Provides long-lasting protection against bacteria through the activation of an anti-microbial peptide response.
Sebum (oil) regulator: Reduce sebum (oil) production, thus preventing bacterial growth and inflammation.
Antioxidant: Prevent DNA damage, and activation of inflammatory enzymes.
BAKUCHIOL
Anti-inflammatory: Suppresses pro-inflammatory cytokine expression. It is a potent anti-inflammatory agent able to control leukocytic functions.
Anti-bacterial: Significant antibacterial activities against Gram positive and negative bacteria.
Anti-keratinizing: Inhibits skin cells (keratinocytes) from abnormally multiplying.
Sebum (oil) regulator: Reduce sebaceous glands activity, leading to less pore clogging and potentially less oil production.
REVIEWS ON DERMEXCEL™ TREATMENT SERUMS
TREATMENT PACKS CONTAINING LITADERM SERUM
PIGMENTATION TREATMENT PACKS
ROSACEA TREATMENT PACKS
ACNE TREATMENT PACKS
"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" .
Dr. Y Lamberts
"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."
Dr. C Giezing
"I see impressive results with DermExcel in my practice. My patients are amazed by the results".
Dr. N Msizi
DERMEXCEL™
Medical-grade skin care products formulated according to pharmaceutical standards of purity, potency, and stability. All active ingredients and the concentrations and dosing protocols in which they are used are supported by data published in the peer-reviewed medical literature.
DermExcel™ takes an easy, effective and affordable approach to evaluating and treating the skin. Targeted treatments to improve skin conditions and maintain skin health.
FREQUENTLY ASKED QUESTIONS
Yes. The topical use of the active ingredients in Litaderm serum is considered safe during pregnancy.
Ref: The American College Of Obstetricians and Gynecologists
Women want to look their best at this important time in their lives, so it's crucial to determine which products and ingredients are safe to use during pregnancy.
Except for the two prescription molecules, hydroquinone (which has a relatively high systemic absorption rate) and tretinoin (for which the evidence is limited and controversial), skincare products act locally and produce minimal systemic levels. In most cases, women can deal with these cosmetically unappealing skin conditions without compromising the safety of their unborn children.
No DermExcel™ product contains hydroquinone or tretinoin. These active ingredients are only available by prescription from a medical doctor.
DermExcel™ Retinol serum contains an active ingredient very similar to tretinoin. We, therefore, advise customers to discontinue the use of Retinol serum until after pregnancy.
For more information regarding the use of DermExcel™ products during pregnancy - please consult with your medical practitioner.
Litaderm serum can be paired with any other DermExcel treatment serum.
Morning: Alternate Litaderm serum with Collagen serum or apply Litaderm after Collagen serum.
Evening: Alternate Litaderm serum with Retinol serum, or use both serums on the same night, in any order you prefer.
Inflacin serum can be applied in the morning and/or evening.
Normal reactions may include stinging or burning, skin peeling, or skin irritation.
Follow the below guidelines to manage the initial irritation reaction:
- Contra-indications of Inflacin serum: Patients with a known allergy to any of the ingredients in Acne Repair serum should not use it.
- Acne patients: Inflacin serum has many benefits and proven efficacy for treating acne.
- Sensitive skin: For sensitive skin or skin not used to active ingredients, start Inflacin serum every other day. Initial sensitivity reactions may occur.
- Resistant skin can use Inflacin serum morning and / or night as tolerated.
Medical skincare products are more focused on the formulation of advanced serums rather than moisturisers for the following reason:
Moisturisers are primarily designed to hydrate the skin by adding to- and sealing in the natural moisture of the body.
Although moisturisers often contain ingredients to target specific issues like aging or sun damage, their main role is to get hydration to the skin and keep it there.
Serums, on the other hand, are formulated to penetrate deeply into the skin and address or even reverse the causes of aging and skin damage at the cellular level.
Serums contain more active ingredients, antioxidants, nutrients, and vitamins that work to repair the structure of skin cells, increasing skin radiance, smoothness, and suppleness.
Dermal Health Science™ products are formulated and manufactured in a facility regulated by the South African Pharmacy Council (SAPC), the regulator established in terms of the Pharmacy Act, 1974 (Act 53 of 1974).
All product formulations are free from any known or common allergens.
DermExcel products are:
- Fragrance-free
- Paraben-free
- Non-comedogenic
- pH-optimized
- Clinically tested
Click here to learn more about Dermal Health Science™
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