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- Facial acne and/or congested pores
- Body Acne
- Keratosis pilaris (bumpy skin on upper arms and/or thighs)
- Shaving bumps / Ingrown hair / folliculitis
ACTIVE INGREDIENTS:
- Salicylic acid: 15%
- Salicylic acid: 30%
TIME OF APPLICATION:
- Apply in the evening on cleansed skin.
- Leave on for at least 30 min. or overnight. If your skin burns beyond tolerability, rinse off.
- Avoid sensitive areas like eyelids and lips.
FREQUENCY OF APPLICATION:
- Do not exceed the application frequency of once every two weeks.
WARNING:
- Always use SPF 30 or greater during the day.
SALICYLIC ACID MODE OF ACTION
- Salicylic acid works by loosening and breaking apart desmosomes (attachments between cells in the outer layers of the skin). This action encourages exfoliation of dead and damaged skin and unclogging of pores.
- Disrupts cellular junctions to exfoliate dead skin cells.
- Salicylic acid is lipophilic, which means it can penetrate oily skin and clogged pores, resulting in deep cleaning.
- Decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.
- Salicylic acid reduces sebum secretion.
- Salicylic acid has potent anti-inflammatory effects, as it is an inhibitor of the arachidonic acid cascade.
- Salicylic acid reduces inflammation by modulating COX2 gene expression to decrease the formation of pro-inflammatory cytokines.
- Inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis. Therefore, salicylic acid may neutralize the bacteria C. acnes present in the blemishes.
- Salicylic acid works well to balance sebum levels because it is lipid or oil soluble. So rather than remaining on the skin's surface, salicylic acid penetrates deep into sebum-filled pores.
- In addition to functioning as an acne treatment, salicylic acid is used in anti-aging skincare products due to its ability to brighten the complexion. It acts as an exfoliant by softening and dissolving keratin, thus allowing dead skin cells to shed naturally.
- Studies have suggested that the exfoliating properties of salicylic acid may reduce the appearance of fine lines and wrinkles. Over time, exfoliation helps to reduce the thickness of the layer of dead skin cells, giving the skin a brighter, more glowing appearance.
INDICATIONS FOR EXCELERATE
- Acne and congested pores
- Inflammation
- Shaving bumps, Ingrown hair or Folliculitis
- Keratosis Pilaris (Bumps on upper arms and thighs)
SALICYLIC ACID TARGETS ALL PHASES OF THE ACNE PROCESS
PROCESS
- The first step in forming a blemish involves sebum, a naturally occurring oily substance that moisturizes, lubricates, and protects the skin and hair. While sebum production is normal, too much sebum can lead to clogged pores.
TARGETED TREATMENT
- Salicylic acid balances sebum levels because it is lipid or oil soluble. So rather than remaining on the skin's surface, salicylic acid penetrates deep into sebum-filled pores.
PROCESS
- The next step in the development of acne is triggered when follicles in the skin are not exfoliating properly. This means that keratin, a protein found within the skin, and sebum clog the follicle.
TARGETED TREATMENT
- Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.
- Salicylic acid disrupts cellular junctions to exfoliate dead skin cells.
PROCESS
- When the follicle becomes clogged, a species of bacteria called Cutibacterium acnes (formerly Propionibacterium acnes) accumulates and multiplies in the follicle.
TARGETED TREATMENT
- Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.
PROCESS
- After bacterial infiltration the follicle becomes inflamed, thus leading to pimple formation.
TARGETED TREATMENT
- Salicylic acid suppresses pro-inflammatory cytokine expression.
- Salicylic acid inhibits the arachidonic acid cascade.
Salicylic acid is approved by the US Food and Drug Administration or FDA for use in OTC drug products. In addition to being FDA-approved as a safe and effective acne drug product, it is also approved for use in OTC drugs for corn, callus, wart removal, and anti-dandruff drug products.
MODE OF ACTION OF EXCELERATE ON ACNE
Regulate sebum (oil) production and excretion
SALICYLIC ACID
- The excretion of lipids by the sebaceous glands is controlled hormonally.
- The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
- These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
- This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
- Hormones continue to affect sebaceous gland activity into adulthood.
Salicylic acid is oil soluble and penetrates deep into sebum-filled pores.
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Prevent the build-up of dead skin cells and oil in pores.
SALICYLIC ACID
- The first stage of acne is called comedogenesis (formation of comedones).
- The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
- This is caused by several factors, including increased amounts of sebum, inflammation of the sides of the hair follicle preventing the release of the exfoliated keratinocytes, and increased cohesion of keratinocytes.
Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris in the pores and follicles.
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Prevent bacterial infiltration
SALICYLIC ACID
- The keratinocyte plug and sebum provide excellent food sources for bacteria.
- The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.
Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.
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Down-regulate the inflammatory response
SALICYLIC ACID
- Inflammation continues with increased redness and pus.
- This is clinically detectable as a papule or pustule.
- Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
- When severe, this can lead to scarring.
Salicylic acid suppresses pro-inflammatory cytokine expression.
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SALICYLIC ACID MODE OF ACTION ON PORES
Salicylic acid is anti-inflammatory and oil-soluble, which means that it can easily penetrate pores to unclog them.
Salicylic acid unclogs pores by loosening and detaching the dead skin cells and other debris that build up within the pore.
Furthermore, due to Salicylic acid's ability to dissolve in oil, it can penetrate the oil glands and reduce oil production.
BLOCKED PORE
Pore that is blocked with dead skin cells and sebum (oil).
Pore that is blocked with dead skin cells and sebum (oil).
Oil-soluble Salicylic acid penetrates the clogged pore and extracts the cellular debris and oil.
Clean follicle/pore by the action of Salicylic acid.
SALICYLIC ACID ACTION
Oil-soluble Salicylic acid penetrates the clogged pore and extracts the cellular debris and oil.
CLEAN PORE
Clean follicle/pore by the action of Salicylic acid.
TREATMENT PACKS CONTAINING LITADERM SERUM
PIGMENTATION TREATMENT PACKS
ROSACEA TREATMENT PACKS
ACNE TREATMENT PACKS
"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" .
Dr. Y Lamberts
"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."
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"I see impressive results with DermExcel in my practice. My patients are amazed by the results".
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DERMEXCEL™
Medical-grade skin care products formulated according to pharmaceutical standards of purity, potency, and stability. All active ingredients, and the concentrations and dosing protocols in which they are used, are supported by data published in the peer-reviewed medical literature.
DermExcel™ takes an easy, effective and affordable approach to evaluating and treating the skin. Targeted treatments to improve skin conditions and maintain skin health.
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