- Dry and dehydrated skin: Soothe, nourish, and calm dry skin by providing long-lasting hydration and supporting the skin's natural barrier.
- Compromised skin barrier: Intelligent Lipid Bilayer technology helps to regulate water loss, strengthen, and regenerate the skin's natural barrier.
- Ichthyosis / Itching: The moisturizing and calming ingredients in Cremedify help alleviate itching associated with dry skin.
- Sensitive skin: Gentle formulation suitable for individuals with sensitive skin, providing effective cleansing without irritation.
- Atopic dermatitis / Eczema: Reinforce the skin's natural barrier and address the symptoms of eczema, including dryness, itching, and inflammation.
- Psoriasis: Relieve symptoms of psoriasis, such as dryness, itching, and inflammation.
SKIN BARRIER COMPONENTS:
- Niacinamide: Vitamin B3 that strengthens the skin's barrier function, improves skin texture, and retains moisture.
- Essential fatty acids: Mimic and reinforce the structure and function of the skin's lipid barrier. Help maintain skin hydration, elasticity, and barrier integrity.
- Lipid Bilayer Technology: Forms an intelligent structural bilayer on the skin that mimics and reinforces the skin's natural lipid barrier function.
HUMECTANTS:
- Sodium hyaluronate: A form of hyaluronic acid, that holds a large amount of water, which helps to maintain skin hydration and plumpness.
- Glycerin: Attracts water from the environment and the deeper layers of the skin, helping to keep the skin hydrated and moisturized.
OCCLUSIVES:
- Paraffinum liquidum: Helps to lock in moisture by forming a thin film on the skin.
- Highly refined medical-grade white soft paraffin: Forms a protective barrier on the skin's surface, sealing in moisture.
EMOLLIENTS:
- Lipid Bilayer Technology: Forms an intelligent structural bilayer on the skin that mimics and reinforces the skin's natural lipid barrier function.
- Paraffinum liquidum: Forms a thin film on the skin, providing a barrier that helps lock in moisture.
- Ethylhexyl glycerin: Skin-conditioning agent that improves the skin's softness and smoothness.
- Cetyl alcohol: A fatty alcohol that smooths and moisturizes the skin.
- Isostearate: Softens and smoothes the skin while providing a protective barrier to lock in moisture.
- Cetyl stearate: A fatty alcohol that smooths and moisturizes the skin while providing a protective barrier to lock in moisture.
FULL INGREDIENT LIST:
White soft paraffin, glycerin, purified water, cetomacrogol, paraffinum liquidum, ethyl hexyl glycerin & phenoxyethanol, cetyl alcool, isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, niacinamide, decyl glucoside, lauryl glucoside, sodium hyaluronate.
- Apply a generous amount on dry or damp skin before getting in the bath or shower.
- Step into the bath or shower and gently rinse off the cleanser, not rubbing the skin vigorously.
- Pat yourself dry with a clean, soft towel. Avoid rubbing or excessive friction, as this may cause irritation.
- For optimal results, follow up with Dermaplan Curexema™ directly after getting out of the bath or shower while skin is still damp.
- Use Cremedify™ moisturizing body cleanser daily as part of your regular shower or bath routine.
KEY BENEFITS OF CREMEDIFY™ BODY CLEANSER

- Targeted Formulation: Cremedify is specifically formulated to address the needs of individuals with dry, itching, psoriasis, atopic dermatitis, and eczema-prone skin. The creamy, non-foaming texture offers gentle cleansing without causing further irritation, making it a suitable choice for sensitive skin.
- Intelligent Lipid Bilayer Technology: This innovative technology enables Cremedify to form a double structural layer on the skin's surface, which effectively regulates water loss, strengthens and regenerates the skin's natural barrier, and ensures long-lasting hydration. This is crucial for maintaining healthy, comfortable skin.
- Barrier Support: Cremedify contains essential fatty acids that mimic and support the epidermal barrier. By reinforcing the skin's natural defenses, Cremedify helps to protect against environmental stressors and minimize the risk of irritation or flare-ups.
- Nourishing Ingredients: Cremedify features powerful, skin-loving ingredients in a harmonious formulation that effectively contribute to overall skin health and vitality.
- Gentle, Non-foaming Cleansing: Traditional body cleansers often produce foam due to harsh surfactants, which can strip the skin of essential moisture and exacerbate dryness and irritation. Cremedify's non-foaming formula ensures a gentle cleansing experience without compromising the skin's integrity.
INDICATIONS FOR CREMEDIFY™ BODY CLEANSER

- Atopic dermatitis / Eczema: Reinforce the skin's natural barrier and address the symptoms of eczema, including dryness, itching, and inflammation.
- Psoriasis: Relieve symptoms of psoriasis, such as dryness, itching, and inflammation.
- Dry and dehydrated skin: Soothe, nourish, and calm dry skin by providing long-lasting hydration and supporting the skin's natural barrier.
- Sensitive skin: Gentle formulation suitable for individuals with sensitive skin, providing effective cleansing without irritation.
- Ichthyosis / Itching: The moisturizing and calming ingredients in Cremedify help alleviate itching associated with dry skin.
- Compromised skin barrier: Intelligent Lipid Bilayer technology helps to regulate water loss, strengthen, and regenerate the skin's natural barrier.
WHAT IS DRY SKIN?
- Dry skin is characterised by the lack of moisture in the stratum corneum (SC). This is the outermost skin layer.
- Water is the major softener of the skin, and when levels are low, cracks and fissures occur.
- For the skin to appear and feel normal, the water content of the SC must be greater than 10%.
- A disruption or defect in the skin's permeability barrier, allows excessive water to be lost from within the skin into the atmosphere. Referred to as transepidermal water loss (TEWL).
- When skin becomes too dry, the outer skin layers stiffen and may develop cracks. The cracks become fissures in the skin that become irritated, inflamed, and itchy.
CLEANSING CONSIDERATIONS FOR ECZEMA / DRY SKIN WITH BARRIER IMPAIRMENT

Gentle cleansing
The primary objective when cleansing eczema-prone skin is to use a gentle, non-irritating cleanser.
Cremedify is a non-foaming cleanser that effectively removes dirt and impurities without stripping the skin of its natural oils, helping maintain the skin's moisture balance.

Reducing inflammation
Eczema / Atopic Dermatitis is marked by inflammation, which causes redness, itching, and discomfort.
Cremedify contains soothing and nourishing ingredients like ceramides, essential fatty acids, and niacinamide that help reduce inflammation and calm irritated skin.

Strengthening the skin barrier
A weakened skin barrier and dry, dehydrated skin can exacerbate eczema symptoms.
Cremedify's Intelligent Lipid Bilayer technology forms a double structural layer on the skin's surface, helping to regulate water loss, reinforce the skin's natural barrier, and promote long-lasting hydration.

Moisturizing
Eczema-prone skin often suffers from excessive dryness, making it essential to keep the skin hydrated.
Cremedify, with its nourishing ingredients, ensures that the skin remains moisturized, alleviating dryness and itchiness associated with eczema.

Preventing infections
Eczema can sometimes lead to secondary infections due to broken skin or excessive scratching.
By effectively cleansing and providing a soothing effect, Cremedify helps reduce the risk of infections by removing bacteria and reducing the urge to scratch.

Maintaining skin pH
A balanced skin pH is crucial for maintaining healthy skin.
Cremedify is designed to gently cleanse the skin without disrupting its natural pH levels, ensuring that the skin's protective barrier remains intact.
SKIN BARRIER FUNCTION


The 2 PRIMARY FUNCTIONS OF THE skin barrier
- PERMEABILITY BARRIER: Creating a barrier against electrolytes- and moisture loss (TEWL - Trans-epidermal Water loss)
- ANTIMICROBIAL BARRIER: Creating a barrier against the entry of unwanted microorganisms such as allergens and irritants. This function protects the skin against irritant dermatitis and skin infections.


Both of these barriers are localised primarily to the stratum corneum layer of the epidermis (the outermost layer of the skin).
When these barrier functions are impaired, the result is: DRY SKIN
When these barrier functions are impaired, the result is: DRY SKIN
The 2 PRIMARY FUNCTIONS OF THE skin barrier




PERMEABILITY BARRIER
Creating a barrier against electrolytes- and moisture loss (TEWL - Trans-epidermal Water loss).
This function protects the skin against becoming dry.


ANTIMICROBIAL BARRIER
Creating a barrier against the entry of unwanted micro-organisms such as allergens and irritants.
This function protects the skin against irritant dermatitis and skin infections.

PERMEABILITY BARRIER
Creating a barrier against electrolytes- and moisture loss
(TEWL - Trans-epidermal Water loss).
This function protects the skin against becoming dry.

ANTIMICROBIAL BARRIER
Creating a barrier against the entry of unwanted microorganisms such as allergens and irritants.
This function protects the skin against irritant dermatitis and skin infections.
Both of these barriers are localised primarily to the stratum corneum layer of the epidermis (the outermost layer of the skin).
When these barrier functions are impaired, the result is: DRY SKIN
When these barrier functions are impaired, the result is:
DRY SKIN
Both of these barriers are localised primarily to the stratum corneum layer of the epidermis (the outermost layer of the skin).
When these barrier functions are impaired, the result is: DRY SKIN
Skin Barrier Impairment results in:
DRY SKINCREMEDIFY™ MOISTURISER CLASSES MODE OF ACTION
TRIPLE PHYSIOLOGIC LIPID-BASED BARRIER REPAIR THERAPY




- Unlike moisturisers, topical triple physiologic lipid-based technology amplifies lipid production and replenishes the lamellar bilayers that are critical for normal barrier function and antimicrobial defence.
- Topically applied physiologic lipids, in contrast to moisturisers, do not form an occlusive layer on the SC surface. Instead, they are quickly absorbed into the underlying nucleated cell layers, where they incorporate into lamellar bodies.
- This Barrier Repair Therapy furthermore reduce inflammation by several mechanisms.
- This leads to a smoother surface with less friction and greater light refraction.
Physiologically replenish the lipid bilayers that are critical for normal barrier function and antimicrobial defence.
EMOLLIENTS




- Emollients soften and smooth the skin.
- They function by filling the gaps between skin cells and replace missing lipids.
- Emollients flatten the curled edges of the individual skin cells (corneocytes).
- This leads to a smoother surface with less friction and greater light refraction.
Fill the gaps between skin cells and replace missing lipids.
HUMECTANTS




- Humectants are water-soluble materials with high water absorption capabilities.
- Draw moisture from the air into the skin and/or draw moisture from the dermis into the epidermis.
- The attract water from the atmosphere and from the underlying dermis into the epidermis (outer skin layer).
- Although humectants may draw water from the environment to help hydrate the skin, in low-humidity conditions they may take water from the deeper epidermis and dermis resulting in increased skin dryness. For this reason, they work better when combined with occlusives.
Draw moisture from the air into the skin and/or draw moisture from the underlying dermis into the epidermis.
OCCLUSIVES


- Occlusives create a protective layer on top of the skin that prevent water loss and “seal” in moisture.
- Occlusives coat the stratum corner (outermost skin layer) to retard transepidermal water loss (TEWL).
- Occlusives is one of the best choices to treat dry skin because it provides an emollient effect as well as decreases TEWL.
- Occlusive agents are only effective while present on the skin; once removed, TEWL returns to the previous level.
Creates a protective layer on top of the skin that prevents water loss and “seals” in moisture.
WHICH DERMAPLAN™ MOISTURISER SHOULD I USE?

HYDRABASE™
For individuals experiencing aging, sun-damaged, or dry skin, as well as individuals seeking a daily body lotion to enhance and maintain their skin's natural moisture levels. Hydrabase is suitable for individuals looking for a deeply moisturizing and nourishing product to revitalize, soothe, and repair their skin while also improving its texture and resilience.

CUREXEMA™
For individuals struggling with eczema, dry and dehydrated skin, psoriasis, and rough and scaling skin conditions. This product is ideal for those seeking a powerful and effective solution to restore and maintain their skin's health and integrity while relieving itching, dryness, redness, and irritation.

MEDIMENT™
For individuals with severely dry and irritated skin conditions, such as redness, irritation, excessive dryness, cracking, scaling, and chapping. This water-free, lipid-replenishing ointment is ideal for clients looking to create a protective barrier on their skin while facilitating an ideal environment for healing and skin regeneration. Mediment is suitable for the entire family including infants and the elderly. It is also a fantastic ointment for baby's bum.
DERMEXCEL™ HYDRATORS & MOISTURISERS REVIEWS
TREATMENT PACKS CONTAINING LITADERM SERUM
PIGMENTATION TREATMENT PACKS
ROSACEA TREATMENT PACKS
ACNE TREATMENT PACKS
"I recommend DermExcel to all my patients. Not only is it formulated by the best pharmacologists in the industry, it's also the best value for money skin care range available" .
Dr. Y Lamberts
"DermExcel brings a whole new dimension to the science-based, medical practitioner powered skincare we recommend to our patients. It's also the skincare range I personally use every day."
Dr. C Giezing
"I see impressive results with DermExcel in my practice. My patients are amazed by the results".
Dr. N Msizi
ABOUT DERMAPLAN™

Dermaplan offers expertly formulated, scientifically proven solutions for various skin concerns. Our passion for skin health and commitment to innovation has led us to create products that address our customers' unique needs. We strive to redefine body skincare standards by developing safe, effective, and clinically tested products for those struggling with skin conditions.
Our team of experienced pharmaceutical chemists and pharmacologists collaborates to create advanced formulations that address the root causes of skin challenges, such as eczema, psoriasis, dryness, and aging.
Our comprehensive, holistic approach to skincare focuses on repairing, nourishing, and protecting the skin's natural barrier using potent, high-quality ingredients and innovative technologies. Rigorous testing and adherence to the highest industry standards ensure the safety, quality, and efficacy of our products.
Discover the Dermaplan difference and let us be your partner in skin health, guiding you towards a future of comfort, confidence, and radiance.